Prostaglandin A1 Inhibits Replication of Classical Swine Fever Virus

Detalhes bibliográficos
Autor(a) principal: Freitas,Tânia Rosária Pereira
Data de Publicação: 1998
Outros Autores: Caldas,Lucio Ayres, Rebello,Moacyr Alcoforado
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000600021
Resumo: Prostaglandins (Pgs) have been shown to inhibit the replication of several DNA and RNA viruses. Here we report the effect of prostaglandin (PgA1) on the multiplication of a positive strand RNA virus, Classical Swine Fever Virus (CSFV) in PK15 cells. PgA1 was found to inhibit the multiplication of CSFV. At a concentration of 5 µg/ml, which was nontoxic to the cells, PgA1 inhibitis virus production in 99%. In PgA1 treated cells the size and number of characteristic Classical Swine Fever focus decreased in amount.
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spelling Prostaglandin A1 Inhibits Replication of Classical Swine Fever VirusClassical Swine Fever VirusProstaglandinPK15 cellvirus replicationProstaglandins (Pgs) have been shown to inhibit the replication of several DNA and RNA viruses. Here we report the effect of prostaglandin (PgA1) on the multiplication of a positive strand RNA virus, Classical Swine Fever Virus (CSFV) in PK15 cells. PgA1 was found to inhibit the multiplication of CSFV. At a concentration of 5 µg/ml, which was nontoxic to the cells, PgA1 inhibitis virus production in 99%. In PgA1 treated cells the size and number of characteristic Classical Swine Fever focus decreased in amount.Instituto Oswaldo Cruz, Ministério da Saúde1998-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000600021Memórias do Instituto Oswaldo Cruz v.93 n.6 1998reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761998000600021info:eu-repo/semantics/openAccessFreitas,Tânia Rosária PereiraCaldas,Lucio AyresRebello,Moacyr Alcoforadoeng2020-04-25T17:47:56Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:08:23.436Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Prostaglandin A1 Inhibits Replication of Classical Swine Fever Virus
title Prostaglandin A1 Inhibits Replication of Classical Swine Fever Virus
spellingShingle Prostaglandin A1 Inhibits Replication of Classical Swine Fever Virus
Freitas,Tânia Rosária Pereira
Classical Swine Fever Virus
Prostaglandin
PK15 cell
virus replication
title_short Prostaglandin A1 Inhibits Replication of Classical Swine Fever Virus
title_full Prostaglandin A1 Inhibits Replication of Classical Swine Fever Virus
title_fullStr Prostaglandin A1 Inhibits Replication of Classical Swine Fever Virus
title_full_unstemmed Prostaglandin A1 Inhibits Replication of Classical Swine Fever Virus
title_sort Prostaglandin A1 Inhibits Replication of Classical Swine Fever Virus
author Freitas,Tânia Rosária Pereira
author_facet Freitas,Tânia Rosária Pereira
Caldas,Lucio Ayres
Rebello,Moacyr Alcoforado
author_role author
author2 Caldas,Lucio Ayres
Rebello,Moacyr Alcoforado
author2_role author
author
dc.contributor.author.fl_str_mv Freitas,Tânia Rosária Pereira
Caldas,Lucio Ayres
Rebello,Moacyr Alcoforado
dc.subject.por.fl_str_mv Classical Swine Fever Virus
Prostaglandin
PK15 cell
virus replication
topic Classical Swine Fever Virus
Prostaglandin
PK15 cell
virus replication
dc.description.none.fl_txt_mv Prostaglandins (Pgs) have been shown to inhibit the replication of several DNA and RNA viruses. Here we report the effect of prostaglandin (PgA1) on the multiplication of a positive strand RNA virus, Classical Swine Fever Virus (CSFV) in PK15 cells. PgA1 was found to inhibit the multiplication of CSFV. At a concentration of 5 µg/ml, which was nontoxic to the cells, PgA1 inhibitis virus production in 99%. In PgA1 treated cells the size and number of characteristic Classical Swine Fever focus decreased in amount.
description Prostaglandins (Pgs) have been shown to inhibit the replication of several DNA and RNA viruses. Here we report the effect of prostaglandin (PgA1) on the multiplication of a positive strand RNA virus, Classical Swine Fever Virus (CSFV) in PK15 cells. PgA1 was found to inhibit the multiplication of CSFV. At a concentration of 5 µg/ml, which was nontoxic to the cells, PgA1 inhibitis virus production in 99%. In PgA1 treated cells the size and number of characteristic Classical Swine Fever focus decreased in amount.
publishDate 1998
dc.date.none.fl_str_mv 1998-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000600021
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000600021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761998000600021
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.93 n.6 1998
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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