Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis

Detalhes bibliográficos
Autor(a) principal: Dias,Alyria Teixeira
Data de Publicação: 2011
Outros Autores: Castro,Sandra Bertelli Ribeiro de, Alves,Caio César Souza, Rezende,Alice Belleigoli, Rodrigues,Michele Fernandes, Machado,Rachel Rocha Pinheiro, Fernandes,Adriana, Negrão-Corrêa,Deborah, Teixeira,Henrique Couto, Ferreira,Ana Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500015
Resumo: The presence of intestinal helminths can down-regulate the immune response required to control mycobacterial infection. BALB/c mice infected with Mycobacterium bovis following an infection with the intestinal helminth Strongyloides venezuelensis showed reduced interleukin-17A production by lung cells and increased bacterial burden. Also, small granulomas and a high accumulation of cells expressing the inhibitory molecule CTLA-4 were observed in the lung. These data suggest that intestinal helminth infection could have a detrimental effect on the control of tuberculosis (TB) and render coinfected individuals more susceptible to the development of TB.
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spelling Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensisM. bovisS. venezuelensiscoinfectionIL-17CTLA-4- tuberculosisThe presence of intestinal helminths can down-regulate the immune response required to control mycobacterial infection. BALB/c mice infected with Mycobacterium bovis following an infection with the intestinal helminth Strongyloides venezuelensis showed reduced interleukin-17A production by lung cells and increased bacterial burden. Also, small granulomas and a high accumulation of cells expressing the inhibitory molecule CTLA-4 were observed in the lung. These data suggest that intestinal helminth infection could have a detrimental effect on the control of tuberculosis (TB) and render coinfected individuals more susceptible to the development of TB.Instituto Oswaldo Cruz, Ministério da Saúde2011-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500015Memórias do Instituto Oswaldo Cruz v.106 n.5 2011reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762011000500015info:eu-repo/semantics/openAccessDias,Alyria TeixeiraCastro,Sandra Bertelli Ribeiro deAlves,Caio César SouzaRezende,Alice BelleigoliRodrigues,Michele FernandesMachado,Rachel Rocha PinheiroFernandes,AdrianaNegrão-Corrêa,DeborahTeixeira,Henrique CoutoFerreira,Ana Paulaeng2020-04-25T17:51:02Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:17:46.341Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis
title Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis
spellingShingle Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis
Dias,Alyria Teixeira
M. bovis
S. venezuelensis
coinfection
IL-17
CTLA-4
- tuberculosis
title_short Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis
title_full Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis
title_fullStr Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis
title_full_unstemmed Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis
title_sort Lower production of IL-17A and increased susceptibility to Mycobacterium bovis in mice coinfected with Strongyloides venezuelensis
author Dias,Alyria Teixeira
author_facet Dias,Alyria Teixeira
Castro,Sandra Bertelli Ribeiro de
Alves,Caio César Souza
Rezende,Alice Belleigoli
Rodrigues,Michele Fernandes
Machado,Rachel Rocha Pinheiro
Fernandes,Adriana
Negrão-Corrêa,Deborah
Teixeira,Henrique Couto
Ferreira,Ana Paula
author_role author
author2 Castro,Sandra Bertelli Ribeiro de
Alves,Caio César Souza
Rezende,Alice Belleigoli
Rodrigues,Michele Fernandes
Machado,Rachel Rocha Pinheiro
Fernandes,Adriana
Negrão-Corrêa,Deborah
Teixeira,Henrique Couto
Ferreira,Ana Paula
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Dias,Alyria Teixeira
Castro,Sandra Bertelli Ribeiro de
Alves,Caio César Souza
Rezende,Alice Belleigoli
Rodrigues,Michele Fernandes
Machado,Rachel Rocha Pinheiro
Fernandes,Adriana
Negrão-Corrêa,Deborah
Teixeira,Henrique Couto
Ferreira,Ana Paula
dc.subject.por.fl_str_mv M. bovis
S. venezuelensis
coinfection
IL-17
CTLA-4
- tuberculosis
topic M. bovis
S. venezuelensis
coinfection
IL-17
CTLA-4
- tuberculosis
dc.description.none.fl_txt_mv The presence of intestinal helminths can down-regulate the immune response required to control mycobacterial infection. BALB/c mice infected with Mycobacterium bovis following an infection with the intestinal helminth Strongyloides venezuelensis showed reduced interleukin-17A production by lung cells and increased bacterial burden. Also, small granulomas and a high accumulation of cells expressing the inhibitory molecule CTLA-4 were observed in the lung. These data suggest that intestinal helminth infection could have a detrimental effect on the control of tuberculosis (TB) and render coinfected individuals more susceptible to the development of TB.
description The presence of intestinal helminths can down-regulate the immune response required to control mycobacterial infection. BALB/c mice infected with Mycobacterium bovis following an infection with the intestinal helminth Strongyloides venezuelensis showed reduced interleukin-17A production by lung cells and increased bacterial burden. Also, small granulomas and a high accumulation of cells expressing the inhibitory molecule CTLA-4 were observed in the lung. These data suggest that intestinal helminth infection could have a detrimental effect on the control of tuberculosis (TB) and render coinfected individuals more susceptible to the development of TB.
publishDate 2011
dc.date.none.fl_str_mv 2011-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500015
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000500015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762011000500015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.106 n.5 2011
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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