Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Memórias do Instituto Oswaldo Cruz |
| Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800005 |
Resumo: | A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives. |
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Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapieslimoneneβ-amino alcoholsynthesisleishmaniasisLeishmania braziliensisneglected diseasesA series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives.Instituto Oswaldo Cruz, Ministério da Saúde2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800005Memórias do Instituto Oswaldo Cruz v.103 n.8 2008reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762008000800005info:eu-repo/semantics/openAccessFerrarini,Stela RGraebin,Cedric SLimberger,JonesCanto,Rômulo FSDias,Daiane ORosa,Ricardo G daMadeira,Maria de FátimaEifler-Lima,Vera Leng2020-04-25T17:50:22Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:15:51.807Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
| dc.title.none.fl_str_mv |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
| title |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
| spellingShingle |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies Ferrarini,Stela R limonene β-amino alcohol synthesis leishmaniasis Leishmania braziliensis neglected diseases |
| title_short |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
| title_full |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
| title_fullStr |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
| title_full_unstemmed |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
| title_sort |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
| author |
Ferrarini,Stela R |
| author_facet |
Ferrarini,Stela R Graebin,Cedric S Limberger,Jones Canto,Rômulo FS Dias,Daiane O Rosa,Ricardo G da Madeira,Maria de Fátima Eifler-Lima,Vera L |
| author_role |
author |
| author2 |
Graebin,Cedric S Limberger,Jones Canto,Rômulo FS Dias,Daiane O Rosa,Ricardo G da Madeira,Maria de Fátima Eifler-Lima,Vera L |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Ferrarini,Stela R Graebin,Cedric S Limberger,Jones Canto,Rômulo FS Dias,Daiane O Rosa,Ricardo G da Madeira,Maria de Fátima Eifler-Lima,Vera L |
| dc.subject.por.fl_str_mv |
limonene β-amino alcohol synthesis leishmaniasis Leishmania braziliensis neglected diseases |
| topic |
limonene β-amino alcohol synthesis leishmaniasis Leishmania braziliensis neglected diseases |
| dc.description.none.fl_txt_mv |
A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives. |
| description |
A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives. |
| publishDate |
2008 |
| dc.date.none.fl_str_mv |
2008-12-01 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800005 |
| url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762008000800005 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
10.1590/S0074-02762008000800005 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
text/html |
| dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
| publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
| dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.103 n.8 2008 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
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Memórias do Instituto Oswaldo Cruz |
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Memórias do Instituto Oswaldo Cruz |
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Fundação Oswaldo Cruz |
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FIOCRUZ |
| institution |
FIOCRUZ |
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Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
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