Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57444 |
Resumo: | CAPES/MEC, CNPq, MCT/CNPq 02/2006 – Universal (Proc. 483674/2006-0). |
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Ferrarini, Stela R.Graebin, Cedric S.Limberger, JonesCanto, Romulo F. S.Dias, Daiane O.Rosa, Ricardo G. daMadeira, Maria de FátimaEifler-Lima, Vera L.2023-03-18T03:39:26Z2023-03-18T03:39:26Z2008FERRARINI, Stela R. et al. Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 8, p. 773-777, Dec. 2008.0074-0276https://www.arca.fiocruz.br/handle/icict/5744410.1590/S0074-027620080008000051678-8060CAPES/MEC, CNPq, MCT/CNPq 02/2006 – Universal (Proc. 483674/2006-0).Universidade Federal do Rio Grande do Sul. Laboratório de Síntese Orgânica Medicinal. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Laboratório de Síntese Orgânica Medicinal. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Laboratório de Catálise por Metais de Transição. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Laboratório de Síntese Orgânica Medicinal. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Laboratório de Síntese Orgânica Medicinal. Porto Alegre, RS, Brasil.Universidade Federal do Rio Grande do Sul. Laboratório de Catálise por Metais de Transição. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Serviço de Parasitologia Clínica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Sul. Laboratório de Síntese Orgânica Medicinal. Porto Alegre, RS, Brasil.A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives.engFiocruz/IOCSynthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLimoneneβ-amino alcoholSynthesisLeishmaniasisLeishmania braziliensisNeglected diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Ferrarini_Stela_etal_INI_2008.pdfve_Ferrarini_Stela_etal_INI_2008.pdfapplication/pdf419329https://www.arca.fiocruz.br/bitstream/icict/57444/2/ve_Ferrarini_Stela_etal_INI_2008.pdf7509bd14d20d5a70582b5894ea1d6450MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57444/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/574442023-03-18 00:42:31.307oai:www.arca.fiocruz.br:icict/57444Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-18T03:42:31Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.en_US.fl_str_mv |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
title |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
spellingShingle |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies Ferrarini, Stela R. Limonene β-amino alcohol Synthesis Leishmaniasis Leishmania braziliensis Neglected diseases |
title_short |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
title_full |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
title_fullStr |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
title_full_unstemmed |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
title_sort |
Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies |
author |
Ferrarini, Stela R. |
author_facet |
Ferrarini, Stela R. Graebin, Cedric S. Limberger, Jones Canto, Romulo F. S. Dias, Daiane O. Rosa, Ricardo G. da Madeira, Maria de Fátima Eifler-Lima, Vera L. |
author_role |
author |
author2 |
Graebin, Cedric S. Limberger, Jones Canto, Romulo F. S. Dias, Daiane O. Rosa, Ricardo G. da Madeira, Maria de Fátima Eifler-Lima, Vera L. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Ferrarini, Stela R. Graebin, Cedric S. Limberger, Jones Canto, Romulo F. S. Dias, Daiane O. Rosa, Ricardo G. da Madeira, Maria de Fátima Eifler-Lima, Vera L. |
dc.subject.en.en_US.fl_str_mv |
Limonene β-amino alcohol Synthesis Leishmaniasis Leishmania braziliensis Neglected diseases |
topic |
Limonene β-amino alcohol Synthesis Leishmaniasis Leishmania braziliensis Neglected diseases |
description |
CAPES/MEC, CNPq, MCT/CNPq 02/2006 – Universal (Proc. 483674/2006-0). |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2023-03-18T03:39:26Z |
dc.date.available.fl_str_mv |
2023-03-18T03:39:26Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FERRARINI, Stela R. et al. Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 8, p. 773-777, Dec. 2008. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/57444 |
dc.identifier.issn.en_US.fl_str_mv |
0074-0276 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0074-02762008000800005 |
dc.identifier.eissn.none.fl_str_mv |
1678-8060 |
identifier_str_mv |
FERRARINI, Stela R. et al. Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 103, n. 8, p. 773-777, Dec. 2008. 0074-0276 10.1590/S0074-02762008000800005 1678-8060 |
url |
https://www.arca.fiocruz.br/handle/icict/57444 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Fiocruz/IOC |
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Fiocruz/IOC |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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