A population-based study of first and second-line drug-resistant tuberculosis in a high-burden area of the Mexico/United States border

Detalhes bibliográficos
Autor(a) principal: Becerril-Montes,Pola
Data de Publicação: 2013
Outros Autores: Said-Fernández,Salvador, Luna-Herrera,Julieta, Caballero-Olín,Guillermo, Enciso-Moreno,José Antonio, Martínez-Rodríguez,Herminia Guadalupe, Padilla-Rivas,Gerardo, Nancy-Garza-Treviño,Elsa, Molina-Salinas,Gloria María
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000200160
Resumo: The resistance of 139 Mycobacterium tuberculosis (MTB) isolates from the city of Monterrey, Northeast Mexico, to first and second-line anti-TB drugs was analysed. A total of 73 isolates were susceptible and 66 were resistant to anti-TB drugs. Monoresistance to streptomycin, isoniazid (INH) and ethambutol was observed in 29 cases. Resistance to INH was found in 52 cases and in 29 cases INH resistance was combined with resistance to two or three drugs. A total of 24 isolates were multidrug-resistant (MDR) resistant to at least INH and rifampicin and 11 MDR cases were resistant to five drugs. The proportion of MDR-TB among new TB cases in our target population was 0.72% (1/139 cases). The proportion of MDR-TB among previously treated cases was 25.18% (35/139 cases). The 13 polyresistant and 24 MDR isolates were assayed against the following seven second-line drugs: amikacin (AMK), kanamycin (KAN), capreomycin (CAP), clofazimine (CLF), ethionamide (ETH), ofloxacin (OFL) and cycloserine (CLS). Resistance to CLF, OFL or CLS was not observed. Resistance was detected to ETH (10.80%) and to AMK (2.70%), KAN (2.70%) and CAP (2.70%). One isolate of MDR with primary resistance was also resistant to three second-line drugs. Monterrey has a high prevalence of MDR-TB among previously treated cases and extensively drug-resistant-MTB strains may soon appear.
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spelling A population-based study of first and second-line drug-resistant tuberculosis in a high-burden area of the Mexico/United States bordertuberculosisMycobacterium tuberculosisfirst and second-line drug resistanceThe resistance of 139 Mycobacterium tuberculosis (MTB) isolates from the city of Monterrey, Northeast Mexico, to first and second-line anti-TB drugs was analysed. A total of 73 isolates were susceptible and 66 were resistant to anti-TB drugs. Monoresistance to streptomycin, isoniazid (INH) and ethambutol was observed in 29 cases. Resistance to INH was found in 52 cases and in 29 cases INH resistance was combined with resistance to two or three drugs. A total of 24 isolates were multidrug-resistant (MDR) resistant to at least INH and rifampicin and 11 MDR cases were resistant to five drugs. The proportion of MDR-TB among new TB cases in our target population was 0.72% (1/139 cases). The proportion of MDR-TB among previously treated cases was 25.18% (35/139 cases). The 13 polyresistant and 24 MDR isolates were assayed against the following seven second-line drugs: amikacin (AMK), kanamycin (KAN), capreomycin (CAP), clofazimine (CLF), ethionamide (ETH), ofloxacin (OFL) and cycloserine (CLS). Resistance to CLF, OFL or CLS was not observed. Resistance was detected to ETH (10.80%) and to AMK (2.70%), KAN (2.70%) and CAP (2.70%). One isolate of MDR with primary resistance was also resistant to three second-line drugs. Monterrey has a high prevalence of MDR-TB among previously treated cases and extensively drug-resistant-MTB strains may soon appear.Instituto Oswaldo Cruz, Ministério da Saúde2013-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000200160Memórias do Instituto Oswaldo Cruz v.108 n.2 2013reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-0276108022013006info:eu-repo/semantics/openAccessBecerril-Montes,PolaSaid-Fernández,SalvadorLuna-Herrera,JulietaCaballero-Olín,GuillermoEnciso-Moreno,José AntonioMartínez-Rodríguez,Herminia GuadalupePadilla-Rivas,GerardoNancy-Garza-Treviño,ElsaMolina-Salinas,Gloria Maríaeng2020-04-25T17:51:23Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:18:52.29Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv A population-based study of first and second-line drug-resistant tuberculosis in a high-burden area of the Mexico/United States border
title A population-based study of first and second-line drug-resistant tuberculosis in a high-burden area of the Mexico/United States border
spellingShingle A population-based study of first and second-line drug-resistant tuberculosis in a high-burden area of the Mexico/United States border
Becerril-Montes,Pola
tuberculosis
Mycobacterium tuberculosis
first and second-line drug resistance
title_short A population-based study of first and second-line drug-resistant tuberculosis in a high-burden area of the Mexico/United States border
title_full A population-based study of first and second-line drug-resistant tuberculosis in a high-burden area of the Mexico/United States border
title_fullStr A population-based study of first and second-line drug-resistant tuberculosis in a high-burden area of the Mexico/United States border
title_full_unstemmed A population-based study of first and second-line drug-resistant tuberculosis in a high-burden area of the Mexico/United States border
title_sort A population-based study of first and second-line drug-resistant tuberculosis in a high-burden area of the Mexico/United States border
author Becerril-Montes,Pola
author_facet Becerril-Montes,Pola
Said-Fernández,Salvador
Luna-Herrera,Julieta
Caballero-Olín,Guillermo
Enciso-Moreno,José Antonio
Martínez-Rodríguez,Herminia Guadalupe
Padilla-Rivas,Gerardo
Nancy-Garza-Treviño,Elsa
Molina-Salinas,Gloria María
author_role author
author2 Said-Fernández,Salvador
Luna-Herrera,Julieta
Caballero-Olín,Guillermo
Enciso-Moreno,José Antonio
Martínez-Rodríguez,Herminia Guadalupe
Padilla-Rivas,Gerardo
Nancy-Garza-Treviño,Elsa
Molina-Salinas,Gloria María
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Becerril-Montes,Pola
Said-Fernández,Salvador
Luna-Herrera,Julieta
Caballero-Olín,Guillermo
Enciso-Moreno,José Antonio
Martínez-Rodríguez,Herminia Guadalupe
Padilla-Rivas,Gerardo
Nancy-Garza-Treviño,Elsa
Molina-Salinas,Gloria María
dc.subject.por.fl_str_mv tuberculosis
Mycobacterium tuberculosis
first and second-line drug resistance
topic tuberculosis
Mycobacterium tuberculosis
first and second-line drug resistance
dc.description.none.fl_txt_mv The resistance of 139 Mycobacterium tuberculosis (MTB) isolates from the city of Monterrey, Northeast Mexico, to first and second-line anti-TB drugs was analysed. A total of 73 isolates were susceptible and 66 were resistant to anti-TB drugs. Monoresistance to streptomycin, isoniazid (INH) and ethambutol was observed in 29 cases. Resistance to INH was found in 52 cases and in 29 cases INH resistance was combined with resistance to two or three drugs. A total of 24 isolates were multidrug-resistant (MDR) resistant to at least INH and rifampicin and 11 MDR cases were resistant to five drugs. The proportion of MDR-TB among new TB cases in our target population was 0.72% (1/139 cases). The proportion of MDR-TB among previously treated cases was 25.18% (35/139 cases). The 13 polyresistant and 24 MDR isolates were assayed against the following seven second-line drugs: amikacin (AMK), kanamycin (KAN), capreomycin (CAP), clofazimine (CLF), ethionamide (ETH), ofloxacin (OFL) and cycloserine (CLS). Resistance to CLF, OFL or CLS was not observed. Resistance was detected to ETH (10.80%) and to AMK (2.70%), KAN (2.70%) and CAP (2.70%). One isolate of MDR with primary resistance was also resistant to three second-line drugs. Monterrey has a high prevalence of MDR-TB among previously treated cases and extensively drug-resistant-MTB strains may soon appear.
description The resistance of 139 Mycobacterium tuberculosis (MTB) isolates from the city of Monterrey, Northeast Mexico, to first and second-line anti-TB drugs was analysed. A total of 73 isolates were susceptible and 66 were resistant to anti-TB drugs. Monoresistance to streptomycin, isoniazid (INH) and ethambutol was observed in 29 cases. Resistance to INH was found in 52 cases and in 29 cases INH resistance was combined with resistance to two or three drugs. A total of 24 isolates were multidrug-resistant (MDR) resistant to at least INH and rifampicin and 11 MDR cases were resistant to five drugs. The proportion of MDR-TB among new TB cases in our target population was 0.72% (1/139 cases). The proportion of MDR-TB among previously treated cases was 25.18% (35/139 cases). The 13 polyresistant and 24 MDR isolates were assayed against the following seven second-line drugs: amikacin (AMK), kanamycin (KAN), capreomycin (CAP), clofazimine (CLF), ethionamide (ETH), ofloxacin (OFL) and cycloserine (CLS). Resistance to CLF, OFL or CLS was not observed. Resistance was detected to ETH (10.80%) and to AMK (2.70%), KAN (2.70%) and CAP (2.70%). One isolate of MDR with primary resistance was also resistant to three second-line drugs. Monterrey has a high prevalence of MDR-TB among previously treated cases and extensively drug-resistant-MTB strains may soon appear.
publishDate 2013
dc.date.none.fl_str_mv 2013-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000200160
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000200160
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-0276108022013006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.108 n.2 2013
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
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repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
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