Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal: Lizcano,Omaira Vera
Data de Publicação: 2014
Outros Autores: Resende,Sarah Stela, Chehuan,Yonne F, Lacerda,Marcus VG, Brito,Cristiana FA, Zalis,Mariano G
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700948
Resumo: The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.
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spelling Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian AmazonPlasmodium vivaxchloroquineresistanceThe molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.Instituto Oswaldo Cruz, Ministério da Saúde2014-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700948Memórias do Instituto Oswaldo Cruz v.109 n.7 2014reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-0276140241info:eu-repo/semantics/openAccessLizcano,Omaira VeraResende,Sarah StelaChehuan,Yonne FLacerda,Marcus VGBrito,Cristiana FAZalis,Mariano Geng2020-04-25T17:51:48Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:19:54.237Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
title Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
spellingShingle Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
Lizcano,Omaira Vera
Plasmodium vivax
chloroquine
resistance
title_short Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
title_full Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
title_fullStr Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
title_full_unstemmed Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
title_sort Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
author Lizcano,Omaira Vera
author_facet Lizcano,Omaira Vera
Resende,Sarah Stela
Chehuan,Yonne F
Lacerda,Marcus VG
Brito,Cristiana FA
Zalis,Mariano G
author_role author
author2 Resende,Sarah Stela
Chehuan,Yonne F
Lacerda,Marcus VG
Brito,Cristiana FA
Zalis,Mariano G
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lizcano,Omaira Vera
Resende,Sarah Stela
Chehuan,Yonne F
Lacerda,Marcus VG
Brito,Cristiana FA
Zalis,Mariano G
dc.subject.por.fl_str_mv Plasmodium vivax
chloroquine
resistance
topic Plasmodium vivax
chloroquine
resistance
dc.description.none.fl_txt_mv The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.
description The molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the molecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax isolates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.
publishDate 2014
dc.date.none.fl_str_mv 2014-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700948
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700948
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-0276140241
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.109 n.7 2014
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
_version_ 1669937716967505920

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