Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms

Detalhes bibliográficos
Autor(a) principal: Colley,D. G.
Data de Publicação: 1987
Outros Autores: Parra,J. C., Montesano,M. A., Lima,M., Nascimento,E., Doughty,B. L., Goes,A., Gazzinelli,G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800017
Resumo: Anti-idiotypic (anti-Id) T cells from schistosomiasis patients or former patients proliferate upon exposure to polyclonal or monoclonal anti-soluble egg antigen (SEA) antibodies. Chloroquine does not inhibit, the response, which is induced by F(ab')2 (but not soluble Fab) fragments of these antibodies. Purified T cells from former patients require macrophages or exogenous IL-1 to respond to anti-SEA Ids and can respond to matrix-bound Fab fragments in the presence of IL-1. These anti-Id T cells recognize the Ids directly. Chronic schistosomiasis patients immunoregulate the production of a non-IL-2 lymphokine that stimulates IL-2 receptor expression on resting T cells. This regulation is reversed upon chemotherapeutic cure.
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spelling Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanismsAnti-idiotypic (anti-Id) T cells from schistosomiasis patients or former patients proliferate upon exposure to polyclonal or monoclonal anti-soluble egg antigen (SEA) antibodies. Chloroquine does not inhibit, the response, which is induced by F(ab')2 (but not soluble Fab) fragments of these antibodies. Purified T cells from former patients require macrophages or exogenous IL-1 to respond to anti-SEA Ids and can respond to matrix-bound Fab fragments in the presence of IL-1. These anti-Id T cells recognize the Ids directly. Chronic schistosomiasis patients immunoregulate the production of a non-IL-2 lymphokine that stimulates IL-2 receptor expression on resting T cells. This regulation is reversed upon chemotherapeutic cure.Instituto Oswaldo Cruz, Ministério da Saúde1987-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800017Memórias do Instituto Oswaldo Cruz v.82 suppl.4 1987reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761987000800017info:eu-repo/semantics/openAccessColley,D. G.Parra,J. C.Montesano,M. A.Lima,M.Nascimento,E.Doughty,B. L.Goes,A.Gazzinelli,G.eng2020-04-25T17:46:00Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:02:09.127Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms
title Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms
spellingShingle Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms
Colley,D. G.
title_short Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms
title_full Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms
title_fullStr Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms
title_full_unstemmed Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms
title_sort Immunoregulation in human Schistosomiasis by idiotypic interactions and lymphokine-mediated mechanisms
author Colley,D. G.
author_facet Colley,D. G.
Parra,J. C.
Montesano,M. A.
Lima,M.
Nascimento,E.
Doughty,B. L.
Goes,A.
Gazzinelli,G.
author_role author
author2 Parra,J. C.
Montesano,M. A.
Lima,M.
Nascimento,E.
Doughty,B. L.
Goes,A.
Gazzinelli,G.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Colley,D. G.
Parra,J. C.
Montesano,M. A.
Lima,M.
Nascimento,E.
Doughty,B. L.
Goes,A.
Gazzinelli,G.
dc.description.none.fl_txt_mv Anti-idiotypic (anti-Id) T cells from schistosomiasis patients or former patients proliferate upon exposure to polyclonal or monoclonal anti-soluble egg antigen (SEA) antibodies. Chloroquine does not inhibit, the response, which is induced by F(ab')2 (but not soluble Fab) fragments of these antibodies. Purified T cells from former patients require macrophages or exogenous IL-1 to respond to anti-SEA Ids and can respond to matrix-bound Fab fragments in the presence of IL-1. These anti-Id T cells recognize the Ids directly. Chronic schistosomiasis patients immunoregulate the production of a non-IL-2 lymphokine that stimulates IL-2 receptor expression on resting T cells. This regulation is reversed upon chemotherapeutic cure.
description Anti-idiotypic (anti-Id) T cells from schistosomiasis patients or former patients proliferate upon exposure to polyclonal or monoclonal anti-soluble egg antigen (SEA) antibodies. Chloroquine does not inhibit, the response, which is induced by F(ab')2 (but not soluble Fab) fragments of these antibodies. Purified T cells from former patients require macrophages or exogenous IL-1 to respond to anti-SEA Ids and can respond to matrix-bound Fab fragments in the presence of IL-1. These anti-Id T cells recognize the Ids directly. Chronic schistosomiasis patients immunoregulate the production of a non-IL-2 lymphokine that stimulates IL-2 receptor expression on resting T cells. This regulation is reversed upon chemotherapeutic cure.
publishDate 1987
dc.date.none.fl_str_mv 1987-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800017
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761987000800017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.82 suppl.4 1987
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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