Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2004 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/7509 |
Resumo: | Texto completo:acesso restrito. p. 341-348. |
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Antonelli, Lis Ribeiro do ValleDutra, Walderez OrnelasAlmeida, Roque Pacheco deBacellar, Maria Olívia Amado RamosGollob, K. J.Antonelli, Lis Ribeiro do ValleDutra, Walderez OrnelasAlmeida, Roque Pacheco deBacellar, Maria Olívia Amado RamosGollob, K. J.2012-12-13T17:47:37Z20040009-9104http://www.repositorio.ufba.br/ri/handle/ri/7509v. 136, n. 2Texto completo:acesso restrito. p. 341-348.Regulation of the immune response directed against Leishmaniais critical for the establishment of effective control of the disease. It is likely that some types of immune responses directed against Leishmania can lead to more severe clinical forms of leishmaniasis causing a poor control of the pathogen and/or pathology, while others lead to resolution of the infection with little pathology as in cutaneous leishmaniasis. To gain a better understanding of the possible role that subpopulations of T cells, and their associated cytokines have on disease progression and/or protective immune responses to L. braziliensis infection, a detailed study of the frequency of activated and memory T cells, as well as antigen specific, cytokine producing T cells was carried out. Following the determination of cytokine producing mononuclear cell populations in response to total Leishmania antigen (SLA), and to the recombinant antigen LACK, correlation analysis were performed between specific cytokine producing populations to identify models for cellular mechanisms of immunoregulation in human cutaneous leishmaniasis.These studies have shown: (1) a positive correlation between ex vivo CD45RO frequencies and antigen specific cytokine (IFN-gamma or IL-10) producing cells; (2) a negative correlation between ex vivo CD69 expression and the frequency of IFN-gamma producing cells; (3) a positive correlation amongst SLA specific, IFN-gamma or TNF-alpha and IL-10 producing lymphocytes with one another; and (4) a higher frequency of IL-10 producing, parasite specific (anti-SLA or anti-LACK), lymphocytes are correlated with a lower frequency of TNF-alpha producing monocytes, demonstrating an antigen specific delivery of IL-10 inducing negative regulation of monocyte activity.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-12-13T17:47:37Z No. of bitstreams: 1 j.1365-2249.2004.02426.x.pdf: 154075 bytes, checksum: b96d36a6be1a7e1d84e73a6a964ddf6a (MD5)Made available in DSpace on 2012-12-13T17:47:37Z (GMT). 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| dc.title.pt_BR.fl_str_mv |
Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation |
| dc.title.alternative.pt_BR.fl_str_mv |
Clinical and Experimental Immunology |
| title |
Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation |
| spellingShingle |
Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation Antonelli, Lis Ribeiro do Valle leishmaniasis cytokines T cells immunoregulation T helper cells |
| title_short |
Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation |
| title_full |
Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation |
| title_fullStr |
Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation |
| title_full_unstemmed |
Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation |
| title_sort |
Antigen specific correlations of cellular immune responses in human leishmaniasis suggests mechanisms for immunoregulation |
| author |
Antonelli, Lis Ribeiro do Valle |
| author_facet |
Antonelli, Lis Ribeiro do Valle Dutra, Walderez Ornelas Almeida, Roque Pacheco de Bacellar, Maria Olívia Amado Ramos Gollob, K. J. |
| author_role |
author |
| author2 |
Dutra, Walderez Ornelas Almeida, Roque Pacheco de Bacellar, Maria Olívia Amado Ramos Gollob, K. J. |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Antonelli, Lis Ribeiro do Valle Dutra, Walderez Ornelas Almeida, Roque Pacheco de Bacellar, Maria Olívia Amado Ramos Gollob, K. J. Antonelli, Lis Ribeiro do Valle Dutra, Walderez Ornelas Almeida, Roque Pacheco de Bacellar, Maria Olívia Amado Ramos Gollob, K. J. |
| dc.subject.por.fl_str_mv |
leishmaniasis cytokines T cells immunoregulation T helper cells |
| topic |
leishmaniasis cytokines T cells immunoregulation T helper cells |
| description |
Texto completo:acesso restrito. p. 341-348. |
| publishDate |
2004 |
| dc.date.issued.fl_str_mv |
2004 |
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2012-12-13T17:47:37Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://www.repositorio.ufba.br/ri/handle/ri/7509 |
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0009-9104 |
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v. 136, n. 2 |
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0009-9104 v. 136, n. 2 |
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http://www.repositorio.ufba.br/ri/handle/ri/7509 |
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elservir |
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