Trypanocidal activity of Meliaceae and Rutaceae plant extracts

Detalhes bibliográficos
Autor(a) principal: Ambrozin,Alessandra Regina Pepe
Data de Publicação: 2004
Outros Autores: Vieira,Paulo Cezar, Fernandes,João Batista, Silva,Maria Fátima das Graças Fernandes da, Albuquerque,Sérgio de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000200020
Resumo: The in vitro trypanocidal activity of 22 extracts and 43 fractions of plants belonging to the families Meliaceae and Rutaceae was evaluated. The extracts from leaves of Conchocarphus heterophyllus and branches of Trichilia ramalhoi were the most active. The trypanocidal activity seems to be increased by fractionation of the extracts. Fractions from C. heterophyllus and Galipea carinata were the most active and a 100% lysis of the parasites was observed for five fractions. From one of them were isolated two flavonoids: flavone and 7-methoxyflavone, which showed weak trypanocidal activity. The results obtained from the extracts and fractions revealed that the order Rutales is a promising source for the search of new drugs for Chagas disease. Phytochemical studies with the other active fractions are underway in order to isolate compounds, which could be associated with observed activities.
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spelling Trypanocidal activity of Meliaceae and Rutaceae plant extractsMeliaceaeRutaceaeChagas diseasetrypanocidal activityThe in vitro trypanocidal activity of 22 extracts and 43 fractions of plants belonging to the families Meliaceae and Rutaceae was evaluated. The extracts from leaves of Conchocarphus heterophyllus and branches of Trichilia ramalhoi were the most active. The trypanocidal activity seems to be increased by fractionation of the extracts. Fractions from C. heterophyllus and Galipea carinata were the most active and a 100% lysis of the parasites was observed for five fractions. From one of them were isolated two flavonoids: flavone and 7-methoxyflavone, which showed weak trypanocidal activity. The results obtained from the extracts and fractions revealed that the order Rutales is a promising source for the search of new drugs for Chagas disease. Phytochemical studies with the other active fractions are underway in order to isolate compounds, which could be associated with observed activities.Instituto Oswaldo Cruz, Ministério da Saúde2004-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000200020Memórias do Instituto Oswaldo Cruz v.99 n.2 2004reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762004000200020info:eu-repo/semantics/openAccessAmbrozin,Alessandra Regina PepeVieira,Paulo CezarFernandes,João BatistaSilva,Maria Fátima das Graças Fernandes daAlbuquerque,Sérgio deeng2020-04-25T17:49:15Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:12:33.166Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Trypanocidal activity of Meliaceae and Rutaceae plant extracts
title Trypanocidal activity of Meliaceae and Rutaceae plant extracts
spellingShingle Trypanocidal activity of Meliaceae and Rutaceae plant extracts
Ambrozin,Alessandra Regina Pepe
Meliaceae
Rutaceae
Chagas disease
trypanocidal activity
title_short Trypanocidal activity of Meliaceae and Rutaceae plant extracts
title_full Trypanocidal activity of Meliaceae and Rutaceae plant extracts
title_fullStr Trypanocidal activity of Meliaceae and Rutaceae plant extracts
title_full_unstemmed Trypanocidal activity of Meliaceae and Rutaceae plant extracts
title_sort Trypanocidal activity of Meliaceae and Rutaceae plant extracts
author Ambrozin,Alessandra Regina Pepe
author_facet Ambrozin,Alessandra Regina Pepe
Vieira,Paulo Cezar
Fernandes,João Batista
Silva,Maria Fátima das Graças Fernandes da
Albuquerque,Sérgio de
author_role author
author2 Vieira,Paulo Cezar
Fernandes,João Batista
Silva,Maria Fátima das Graças Fernandes da
Albuquerque,Sérgio de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ambrozin,Alessandra Regina Pepe
Vieira,Paulo Cezar
Fernandes,João Batista
Silva,Maria Fátima das Graças Fernandes da
Albuquerque,Sérgio de
dc.subject.por.fl_str_mv Meliaceae
Rutaceae
Chagas disease
trypanocidal activity
topic Meliaceae
Rutaceae
Chagas disease
trypanocidal activity
dc.description.none.fl_txt_mv The in vitro trypanocidal activity of 22 extracts and 43 fractions of plants belonging to the families Meliaceae and Rutaceae was evaluated. The extracts from leaves of Conchocarphus heterophyllus and branches of Trichilia ramalhoi were the most active. The trypanocidal activity seems to be increased by fractionation of the extracts. Fractions from C. heterophyllus and Galipea carinata were the most active and a 100% lysis of the parasites was observed for five fractions. From one of them were isolated two flavonoids: flavone and 7-methoxyflavone, which showed weak trypanocidal activity. The results obtained from the extracts and fractions revealed that the order Rutales is a promising source for the search of new drugs for Chagas disease. Phytochemical studies with the other active fractions are underway in order to isolate compounds, which could be associated with observed activities.
description The in vitro trypanocidal activity of 22 extracts and 43 fractions of plants belonging to the families Meliaceae and Rutaceae was evaluated. The extracts from leaves of Conchocarphus heterophyllus and branches of Trichilia ramalhoi were the most active. The trypanocidal activity seems to be increased by fractionation of the extracts. Fractions from C. heterophyllus and Galipea carinata were the most active and a 100% lysis of the parasites was observed for five fractions. From one of them were isolated two flavonoids: flavone and 7-methoxyflavone, which showed weak trypanocidal activity. The results obtained from the extracts and fractions revealed that the order Rutales is a promising source for the search of new drugs for Chagas disease. Phytochemical studies with the other active fractions are underway in order to isolate compounds, which could be associated with observed activities.
publishDate 2004
dc.date.none.fl_str_mv 2004-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000200020
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000200020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762004000200020
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.99 n.2 2004
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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