Atypical epidermal alterations in chronic Leishmania mexicana mexicana lesions fo C3H mice

Detalhes bibliográficos
Autor(a) principal: Grimaldi Junior,G.
Data de Publicação: 1982
Outros Autores: Queiroz,A. C., Moriearty,P. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761982000400006
Resumo: C3H mice chronically infected with Leishmania m. mexicana, and in some groups treated with BCG or levamisole, presented atypical epidermal alterations, including pseudoepitheliomatous hyperplasia, hyperkeratosis and dysplasia. These alterations increased in frequency and intensity during the course of infection, but were not related to lesion size or tissue parasite load. Age matched normal, BCG and levamisole treated control mice, examined simultaneously, did not show epidermal modifications. In infected mice the dermis and hypodermis presented an inflammatory infiltrate of histiocytes, lymphocytes and plasma cells, accompanied at times by neutrophils and eosinophils, which did not vary with duration of infection.
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spelling Atypical epidermal alterations in chronic Leishmania mexicana mexicana lesions fo C3H miceC3H mice chronically infected with Leishmania m. mexicana, and in some groups treated with BCG or levamisole, presented atypical epidermal alterations, including pseudoepitheliomatous hyperplasia, hyperkeratosis and dysplasia. These alterations increased in frequency and intensity during the course of infection, but were not related to lesion size or tissue parasite load. Age matched normal, BCG and levamisole treated control mice, examined simultaneously, did not show epidermal modifications. In infected mice the dermis and hypodermis presented an inflammatory infiltrate of histiocytes, lymphocytes and plasma cells, accompanied at times by neutrophils and eosinophils, which did not vary with duration of infection.Instituto Oswaldo Cruz, Ministério da Saúde1982-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761982000400006Memórias do Instituto Oswaldo Cruz v.77 n.4 1982reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761982000400006info:eu-repo/semantics/openAccessGrimaldi Junior,G.Queiroz,A. C.Moriearty,P. L.eng2020-04-25T17:45:26Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:00:27.034Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Atypical epidermal alterations in chronic Leishmania mexicana mexicana lesions fo C3H mice
title Atypical epidermal alterations in chronic Leishmania mexicana mexicana lesions fo C3H mice
spellingShingle Atypical epidermal alterations in chronic Leishmania mexicana mexicana lesions fo C3H mice
Grimaldi Junior,G.
title_short Atypical epidermal alterations in chronic Leishmania mexicana mexicana lesions fo C3H mice
title_full Atypical epidermal alterations in chronic Leishmania mexicana mexicana lesions fo C3H mice
title_fullStr Atypical epidermal alterations in chronic Leishmania mexicana mexicana lesions fo C3H mice
title_full_unstemmed Atypical epidermal alterations in chronic Leishmania mexicana mexicana lesions fo C3H mice
title_sort Atypical epidermal alterations in chronic Leishmania mexicana mexicana lesions fo C3H mice
author Grimaldi Junior,G.
author_facet Grimaldi Junior,G.
Queiroz,A. C.
Moriearty,P. L.
author_role author
author2 Queiroz,A. C.
Moriearty,P. L.
author2_role author
author
dc.contributor.author.fl_str_mv Grimaldi Junior,G.
Queiroz,A. C.
Moriearty,P. L.
dc.description.none.fl_txt_mv C3H mice chronically infected with Leishmania m. mexicana, and in some groups treated with BCG or levamisole, presented atypical epidermal alterations, including pseudoepitheliomatous hyperplasia, hyperkeratosis and dysplasia. These alterations increased in frequency and intensity during the course of infection, but were not related to lesion size or tissue parasite load. Age matched normal, BCG and levamisole treated control mice, examined simultaneously, did not show epidermal modifications. In infected mice the dermis and hypodermis presented an inflammatory infiltrate of histiocytes, lymphocytes and plasma cells, accompanied at times by neutrophils and eosinophils, which did not vary with duration of infection.
description C3H mice chronically infected with Leishmania m. mexicana, and in some groups treated with BCG or levamisole, presented atypical epidermal alterations, including pseudoepitheliomatous hyperplasia, hyperkeratosis and dysplasia. These alterations increased in frequency and intensity during the course of infection, but were not related to lesion size or tissue parasite load. Age matched normal, BCG and levamisole treated control mice, examined simultaneously, did not show epidermal modifications. In infected mice the dermis and hypodermis presented an inflammatory infiltrate of histiocytes, lymphocytes and plasma cells, accompanied at times by neutrophils and eosinophils, which did not vary with duration of infection.
publishDate 1982
dc.date.none.fl_str_mv 1982-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761982000400006
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761982000400006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761982000400006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.77 n.4 1982
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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