In vivo assessment of antiretroviral therapy-associated side effects

Detalhes bibliográficos
Autor(a) principal: Ramos-Sanchez,Eduardo Milton
Data de Publicação: 2014
Outros Autores: Goto,Hiro, Rivero,Dolores Helena Rodriguez Ferreira, Mauad,Thais, Souza,Fernando Nogueira de, Monteiro,Andrea Moreira, Gidlund,Magnus
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000400484
Resumo: Antiretroviral therapy has been associated with side effects, either from the drug itself or in conjunction with the effects of human immunodeficiency virus infection. Here, we evaluated the side effects of the protease inhibitor (PI) indinavir in hamsters consuming a normal or high-fat diet. Indinavir treatment increased the hamster death rate and resulted in an increase in triglyceride, cholesterol and glucose serum levels and a reduction in anti-oxLDL auto-antibodies. The treatment led to histopathological alterations of the kidney and the heart. These results suggest that hamsters are an interesting model for the study of the side effects of antiretroviral drugs, such as PIs.
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spelling In vivo assessment of antiretroviral therapy-associated side effectsmetabolic disordersprotease inhibitorHIVAntiretroviral therapy has been associated with side effects, either from the drug itself or in conjunction with the effects of human immunodeficiency virus infection. Here, we evaluated the side effects of the protease inhibitor (PI) indinavir in hamsters consuming a normal or high-fat diet. Indinavir treatment increased the hamster death rate and resulted in an increase in triglyceride, cholesterol and glucose serum levels and a reduction in anti-oxLDL auto-antibodies. The treatment led to histopathological alterations of the kidney and the heart. These results suggest that hamsters are an interesting model for the study of the side effects of antiretroviral drugs, such as PIs.Instituto Oswaldo Cruz, Ministério da Saúde2014-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000400484Memórias do Instituto Oswaldo Cruz v.109 n.4 2014reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-0276130559info:eu-repo/semantics/openAccessRamos-Sanchez,Eduardo MiltonGoto,HiroRivero,Dolores Helena Rodriguez FerreiraMauad,ThaisSouza,Fernando Nogueira deMonteiro,Andrea MoreiraGidlund,Magnuseng2020-04-25T17:51:51Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:20:04.034Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv In vivo assessment of antiretroviral therapy-associated side effects
title In vivo assessment of antiretroviral therapy-associated side effects
spellingShingle In vivo assessment of antiretroviral therapy-associated side effects
Ramos-Sanchez,Eduardo Milton
metabolic disorders
protease inhibitor
HIV
title_short In vivo assessment of antiretroviral therapy-associated side effects
title_full In vivo assessment of antiretroviral therapy-associated side effects
title_fullStr In vivo assessment of antiretroviral therapy-associated side effects
title_full_unstemmed In vivo assessment of antiretroviral therapy-associated side effects
title_sort In vivo assessment of antiretroviral therapy-associated side effects
author Ramos-Sanchez,Eduardo Milton
author_facet Ramos-Sanchez,Eduardo Milton
Goto,Hiro
Rivero,Dolores Helena Rodriguez Ferreira
Mauad,Thais
Souza,Fernando Nogueira de
Monteiro,Andrea Moreira
Gidlund,Magnus
author_role author
author2 Goto,Hiro
Rivero,Dolores Helena Rodriguez Ferreira
Mauad,Thais
Souza,Fernando Nogueira de
Monteiro,Andrea Moreira
Gidlund,Magnus
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ramos-Sanchez,Eduardo Milton
Goto,Hiro
Rivero,Dolores Helena Rodriguez Ferreira
Mauad,Thais
Souza,Fernando Nogueira de
Monteiro,Andrea Moreira
Gidlund,Magnus
dc.subject.por.fl_str_mv metabolic disorders
protease inhibitor
HIV
topic metabolic disorders
protease inhibitor
HIV
dc.description.none.fl_txt_mv Antiretroviral therapy has been associated with side effects, either from the drug itself or in conjunction with the effects of human immunodeficiency virus infection. Here, we evaluated the side effects of the protease inhibitor (PI) indinavir in hamsters consuming a normal or high-fat diet. Indinavir treatment increased the hamster death rate and resulted in an increase in triglyceride, cholesterol and glucose serum levels and a reduction in anti-oxLDL auto-antibodies. The treatment led to histopathological alterations of the kidney and the heart. These results suggest that hamsters are an interesting model for the study of the side effects of antiretroviral drugs, such as PIs.
description Antiretroviral therapy has been associated with side effects, either from the drug itself or in conjunction with the effects of human immunodeficiency virus infection. Here, we evaluated the side effects of the protease inhibitor (PI) indinavir in hamsters consuming a normal or high-fat diet. Indinavir treatment increased the hamster death rate and resulted in an increase in triglyceride, cholesterol and glucose serum levels and a reduction in anti-oxLDL auto-antibodies. The treatment led to histopathological alterations of the kidney and the heart. These results suggest that hamsters are an interesting model for the study of the side effects of antiretroviral drugs, such as PIs.
publishDate 2014
dc.date.none.fl_str_mv 2014-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000400484
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000400484
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-0276130559
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.109 n.4 2014
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
_version_ 1669937717058732032

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