Heme and innate immunity: new insights for an old molecule

Detalhes bibliográficos
Autor(a) principal: Arruda,Maria Augusta
Data de Publicação: 2005
Outros Autores: Graça-Souza,Aurélio V, Barja-Fidalgo,Christina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000700022
Resumo: Hemolytic episodes such as sickle cell disease, malaria and ischemia-reperfusion occurrence are often associated to the statement of an inflammatory response which may develop or not to a chronic inflammatory status. Although these pathological states are triggered by distinct etiological agents, all of them are associated to high levels of free heme in circulation. In this review, we aim to focus the very recent achievements that have led to the statement of free heme as a proinflammatory molecule, which may play a central role during the onset and/or persistance of inflammation during these pathologies.
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spelling Heme and innate immunity: new insights for an old moleculeinflammationhemehemolytic episodesHemolytic episodes such as sickle cell disease, malaria and ischemia-reperfusion occurrence are often associated to the statement of an inflammatory response which may develop or not to a chronic inflammatory status. Although these pathological states are triggered by distinct etiological agents, all of them are associated to high levels of free heme in circulation. In this review, we aim to focus the very recent achievements that have led to the statement of free heme as a proinflammatory molecule, which may play a central role during the onset and/or persistance of inflammation during these pathologies.Instituto Oswaldo Cruz, Ministério da Saúde2005-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000700022Memórias do Instituto Oswaldo Cruz v.100 n.7 2005reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762005000700022info:eu-repo/semantics/openAccessArruda,Maria AugustaGraça-Souza,Aurélio VBarja-Fidalgo,Christinaeng2020-04-25T17:49:28Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:13:24.883Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Heme and innate immunity: new insights for an old molecule
title Heme and innate immunity: new insights for an old molecule
spellingShingle Heme and innate immunity: new insights for an old molecule
Arruda,Maria Augusta
inflammation
heme
hemolytic episodes
title_short Heme and innate immunity: new insights for an old molecule
title_full Heme and innate immunity: new insights for an old molecule
title_fullStr Heme and innate immunity: new insights for an old molecule
title_full_unstemmed Heme and innate immunity: new insights for an old molecule
title_sort Heme and innate immunity: new insights for an old molecule
author Arruda,Maria Augusta
author_facet Arruda,Maria Augusta
Graça-Souza,Aurélio V
Barja-Fidalgo,Christina
author_role author
author2 Graça-Souza,Aurélio V
Barja-Fidalgo,Christina
author2_role author
author
dc.contributor.author.fl_str_mv Arruda,Maria Augusta
Graça-Souza,Aurélio V
Barja-Fidalgo,Christina
dc.subject.por.fl_str_mv inflammation
heme
hemolytic episodes
topic inflammation
heme
hemolytic episodes
dc.description.none.fl_txt_mv Hemolytic episodes such as sickle cell disease, malaria and ischemia-reperfusion occurrence are often associated to the statement of an inflammatory response which may develop or not to a chronic inflammatory status. Although these pathological states are triggered by distinct etiological agents, all of them are associated to high levels of free heme in circulation. In this review, we aim to focus the very recent achievements that have led to the statement of free heme as a proinflammatory molecule, which may play a central role during the onset and/or persistance of inflammation during these pathologies.
description Hemolytic episodes such as sickle cell disease, malaria and ischemia-reperfusion occurrence are often associated to the statement of an inflammatory response which may develop or not to a chronic inflammatory status. Although these pathological states are triggered by distinct etiological agents, all of them are associated to high levels of free heme in circulation. In this review, we aim to focus the very recent achievements that have led to the statement of free heme as a proinflammatory molecule, which may play a central role during the onset and/or persistance of inflammation during these pathologies.
publishDate 2005
dc.date.none.fl_str_mv 2005-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000700022
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000700022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762005000700022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.100 n.7 2005
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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