Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity

Detalhes bibliográficos
Autor(a) principal: Rao,V. S. N.
Data de Publicação: 1991
Outros Autores: Almeida,F. R. C., Moraes,A. P., Silva,J. V., Nascimento,S. C., Moraes,M. O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600012
Resumo: Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).
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spelling Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activityantitumorWilbrandia verticillatacytotoxicityWalker carcinosarcomaCucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).Instituto Oswaldo Cruz, Ministério da Saúde1991-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600012Memórias do Instituto Oswaldo Cruz v.86 suppl.2 1991reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761991000600012info:eu-repo/semantics/openAccessRao,V. S. N.Almeida,F. R. C.Moraes,A. P.Silva,J. V.Nascimento,S. C.Moraes,M. O.eng2020-04-25T17:46:38Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:04:14.856Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity
title Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity
spellingShingle Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity
Rao,V. S. N.
antitumor
Wilbrandia verticillata
cytotoxicity
Walker carcinosarcoma
title_short Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity
title_full Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity
title_fullStr Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity
title_full_unstemmed Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity
title_sort Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity
author Rao,V. S. N.
author_facet Rao,V. S. N.
Almeida,F. R. C.
Moraes,A. P.
Silva,J. V.
Nascimento,S. C.
Moraes,M. O.
author_role author
author2 Almeida,F. R. C.
Moraes,A. P.
Silva,J. V.
Nascimento,S. C.
Moraes,M. O.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Rao,V. S. N.
Almeida,F. R. C.
Moraes,A. P.
Silva,J. V.
Nascimento,S. C.
Moraes,M. O.
dc.subject.por.fl_str_mv antitumor
Wilbrandia verticillata
cytotoxicity
Walker carcinosarcoma
topic antitumor
Wilbrandia verticillata
cytotoxicity
Walker carcinosarcoma
dc.description.none.fl_txt_mv Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).
description Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).
publishDate 1991
dc.date.none.fl_str_mv 1991-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600012
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761991000600012
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761991000600012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.86 suppl.2 1991
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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