A comparison of the inhibitory activity of selective PDE4 inhibitors on eosinophil recruitment in guinea pig skin

Detalhes bibliográficos
Autor(a) principal: Teixeira,Mauro M
Data de Publicação: 1997
Outros Autores: Miotla,JM, Cooper,N, Gristwood,RW, Hellewell,PG
Tipo de documento: Artigo
Idioma: por
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000800025
Resumo: The elevation of intracellular cyclic AMP by phosphodiesterase (PDE)4 inhibitors in eosinophils is associated with inhibition of the activation and recruitment of these cells. We have previously shown that systemic treatment with the PDE4 inhibitor rolipram effectively inhibt eosinophil migration in guinea pig skin. In the present study we compare the oral potency and efficacy of the PDE4 inhibitors rolipram, RP 73401 and CDP 840 on allergic and PAF-induced eosinophil recruitment. Rolipram and RP 73401 were equally effective and potent when given by the oral route and much more active than the PDE4 inhibitor CDP 840. We suggest that this guinea pig model of allergic and mediator-induced eosinophil recruitment is both a sensitive and simple tool to test the efficacy and potency of PDE4 inhibitors in vivo.
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spelling A comparison of the inhibitory activity of selective PDE4 inhibitors on eosinophil recruitment in guinea pig skineosinophilsphosphodiesterase inhibitorsrolipramallergic inflammationThe elevation of intracellular cyclic AMP by phosphodiesterase (PDE)4 inhibitors in eosinophils is associated with inhibition of the activation and recruitment of these cells. We have previously shown that systemic treatment with the PDE4 inhibitor rolipram effectively inhibt eosinophil migration in guinea pig skin. In the present study we compare the oral potency and efficacy of the PDE4 inhibitors rolipram, RP 73401 and CDP 840 on allergic and PAF-induced eosinophil recruitment. Rolipram and RP 73401 were equally effective and potent when given by the oral route and much more active than the PDE4 inhibitor CDP 840. We suggest that this guinea pig model of allergic and mediator-induced eosinophil recruitment is both a sensitive and simple tool to test the efficacy and potency of PDE4 inhibitors in vivo.Instituto Oswaldo Cruz, Ministério da Saúde1997-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000800025Memórias do Instituto Oswaldo Cruz v.92 suppl.2 1997reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761997000800025info:eu-repo/semantics/openAccessTeixeira,Mauro MMiotla,JMCooper,NGristwood,RWHellewell,PGpor2020-04-25T17:47:48Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:07:51.323Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv A comparison of the inhibitory activity of selective PDE4 inhibitors on eosinophil recruitment in guinea pig skin
title A comparison of the inhibitory activity of selective PDE4 inhibitors on eosinophil recruitment in guinea pig skin
spellingShingle A comparison of the inhibitory activity of selective PDE4 inhibitors on eosinophil recruitment in guinea pig skin
Teixeira,Mauro M
eosinophils
phosphodiesterase inhibitors
rolipram
allergic inflammation
title_short A comparison of the inhibitory activity of selective PDE4 inhibitors on eosinophil recruitment in guinea pig skin
title_full A comparison of the inhibitory activity of selective PDE4 inhibitors on eosinophil recruitment in guinea pig skin
title_fullStr A comparison of the inhibitory activity of selective PDE4 inhibitors on eosinophil recruitment in guinea pig skin
title_full_unstemmed A comparison of the inhibitory activity of selective PDE4 inhibitors on eosinophil recruitment in guinea pig skin
title_sort A comparison of the inhibitory activity of selective PDE4 inhibitors on eosinophil recruitment in guinea pig skin
author Teixeira,Mauro M
author_facet Teixeira,Mauro M
Miotla,JM
Cooper,N
Gristwood,RW
Hellewell,PG
author_role author
author2 Miotla,JM
Cooper,N
Gristwood,RW
Hellewell,PG
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Teixeira,Mauro M
Miotla,JM
Cooper,N
Gristwood,RW
Hellewell,PG
dc.subject.por.fl_str_mv eosinophils
phosphodiesterase inhibitors
rolipram
allergic inflammation
topic eosinophils
phosphodiesterase inhibitors
rolipram
allergic inflammation
dc.description.none.fl_txt_mv The elevation of intracellular cyclic AMP by phosphodiesterase (PDE)4 inhibitors in eosinophils is associated with inhibition of the activation and recruitment of these cells. We have previously shown that systemic treatment with the PDE4 inhibitor rolipram effectively inhibt eosinophil migration in guinea pig skin. In the present study we compare the oral potency and efficacy of the PDE4 inhibitors rolipram, RP 73401 and CDP 840 on allergic and PAF-induced eosinophil recruitment. Rolipram and RP 73401 were equally effective and potent when given by the oral route and much more active than the PDE4 inhibitor CDP 840. We suggest that this guinea pig model of allergic and mediator-induced eosinophil recruitment is both a sensitive and simple tool to test the efficacy and potency of PDE4 inhibitors in vivo.
description The elevation of intracellular cyclic AMP by phosphodiesterase (PDE)4 inhibitors in eosinophils is associated with inhibition of the activation and recruitment of these cells. We have previously shown that systemic treatment with the PDE4 inhibitor rolipram effectively inhibt eosinophil migration in guinea pig skin. In the present study we compare the oral potency and efficacy of the PDE4 inhibitors rolipram, RP 73401 and CDP 840 on allergic and PAF-induced eosinophil recruitment. Rolipram and RP 73401 were equally effective and potent when given by the oral route and much more active than the PDE4 inhibitor CDP 840. We suggest that this guinea pig model of allergic and mediator-induced eosinophil recruitment is both a sensitive and simple tool to test the efficacy and potency of PDE4 inhibitors in vivo.
publishDate 1997
dc.date.none.fl_str_mv 1997-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000800025
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000800025
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv 10.1590/S0074-02761997000800025
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.92 suppl.2 1997
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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