Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum

Detalhes bibliográficos
Autor(a) principal: Ferreira,Izabel Cristina Piloto
Data de Publicação: 2004
Outros Autores: Lonardoni,Maria Valdrinez Campana, Machado,Gerzia MC, Leon,Leonor L, Gobbi Filho,Lucílio, Pinto,Luís Henrique Bissoli, Oliveira,Arildo José Braz de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300015
Resumo: Infections due to protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials (SbV), which present renal and cardiac toxicity. Besides, the precise chemical structure and mechanism of action of these drugs are unknown up to date. In order to find new drugs against leishmaniasis, we have been studying extracts of Brazilian trees. In the present study, we have evaluated the effectiveness of an alkaloid extract of Aspidosperma ramiflorum Muell. Arg. (Apocynaceae), against the extracellular forms promastigotes of L. (L.) amazonensis and L. (V.) braziliensis. The alkaloid extract of A. ramiflorum was much more effective against L. (L.) amazonensis (LD50 < 47 µg/ml) than L. (V.) braziliensis. Based on these in vitro results against L. (L.) amazonensis new studies should be made to find the compounds with anti-leishmanial activity.
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spelling Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorumApocynaceaeanti-leishmanial activityBrazilian trees- monoterpenoid indolic alkaloidsAspidosperma ramiflorumLeishmania amazonensis- Leishmania braziliensisInfections due to protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials (SbV), which present renal and cardiac toxicity. Besides, the precise chemical structure and mechanism of action of these drugs are unknown up to date. In order to find new drugs against leishmaniasis, we have been studying extracts of Brazilian trees. In the present study, we have evaluated the effectiveness of an alkaloid extract of Aspidosperma ramiflorum Muell. Arg. (Apocynaceae), against the extracellular forms promastigotes of L. (L.) amazonensis and L. (V.) braziliensis. The alkaloid extract of A. ramiflorum was much more effective against L. (L.) amazonensis (LD50 < 47 µg/ml) than L. (V.) braziliensis. Based on these in vitro results against L. (L.) amazonensis new studies should be made to find the compounds with anti-leishmanial activity.Instituto Oswaldo Cruz, Ministério da Saúde2004-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300015Memórias do Instituto Oswaldo Cruz v.99 n.3 2004reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762004000300015info:eu-repo/semantics/openAccessFerreira,Izabel Cristina PilotoLonardoni,Maria Valdrinez CampanaMachado,Gerzia MCLeon,Leonor LGobbi Filho,LucílioPinto,Luís Henrique BissoliOliveira,Arildo José Braz deeng2020-04-25T17:49:15Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:12:36.306Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum
title Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum
spellingShingle Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum
Ferreira,Izabel Cristina Piloto
Apocynaceae
anti-leishmanial activity
Brazilian trees
- monoterpenoid indolic alkaloids
Aspidosperma ramiflorum
Leishmania amazonensis
- Leishmania braziliensis
title_short Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum
title_full Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum
title_fullStr Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum
title_full_unstemmed Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum
title_sort Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum
author Ferreira,Izabel Cristina Piloto
author_facet Ferreira,Izabel Cristina Piloto
Lonardoni,Maria Valdrinez Campana
Machado,Gerzia MC
Leon,Leonor L
Gobbi Filho,Lucílio
Pinto,Luís Henrique Bissoli
Oliveira,Arildo José Braz de
author_role author
author2 Lonardoni,Maria Valdrinez Campana
Machado,Gerzia MC
Leon,Leonor L
Gobbi Filho,Lucílio
Pinto,Luís Henrique Bissoli
Oliveira,Arildo José Braz de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira,Izabel Cristina Piloto
Lonardoni,Maria Valdrinez Campana
Machado,Gerzia MC
Leon,Leonor L
Gobbi Filho,Lucílio
Pinto,Luís Henrique Bissoli
Oliveira,Arildo José Braz de
dc.subject.por.fl_str_mv Apocynaceae
anti-leishmanial activity
Brazilian trees
- monoterpenoid indolic alkaloids
Aspidosperma ramiflorum
Leishmania amazonensis
- Leishmania braziliensis
topic Apocynaceae
anti-leishmanial activity
Brazilian trees
- monoterpenoid indolic alkaloids
Aspidosperma ramiflorum
Leishmania amazonensis
- Leishmania braziliensis
dc.description.none.fl_txt_mv Infections due to protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials (SbV), which present renal and cardiac toxicity. Besides, the precise chemical structure and mechanism of action of these drugs are unknown up to date. In order to find new drugs against leishmaniasis, we have been studying extracts of Brazilian trees. In the present study, we have evaluated the effectiveness of an alkaloid extract of Aspidosperma ramiflorum Muell. Arg. (Apocynaceae), against the extracellular forms promastigotes of L. (L.) amazonensis and L. (V.) braziliensis. The alkaloid extract of A. ramiflorum was much more effective against L. (L.) amazonensis (LD50 < 47 µg/ml) than L. (V.) braziliensis. Based on these in vitro results against L. (L.) amazonensis new studies should be made to find the compounds with anti-leishmanial activity.
description Infections due to protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials (SbV), which present renal and cardiac toxicity. Besides, the precise chemical structure and mechanism of action of these drugs are unknown up to date. In order to find new drugs against leishmaniasis, we have been studying extracts of Brazilian trees. In the present study, we have evaluated the effectiveness of an alkaloid extract of Aspidosperma ramiflorum Muell. Arg. (Apocynaceae), against the extracellular forms promastigotes of L. (L.) amazonensis and L. (V.) braziliensis. The alkaloid extract of A. ramiflorum was much more effective against L. (L.) amazonensis (LD50 < 47 µg/ml) than L. (V.) braziliensis. Based on these in vitro results against L. (L.) amazonensis new studies should be made to find the compounds with anti-leishmanial activity.
publishDate 2004
dc.date.none.fl_str_mv 2004-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300015
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000300015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762004000300015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.99 n.3 2004
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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