Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni

Detalhes bibliográficos
Autor(a) principal: Domingues,Ana Lúcia Coutinho
Data de Publicação: 2011
Outros Autores: Medeiros,Tibério Batista de, Lopes,Edmundo Pessoa de Almeida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000700004
Resumo: In this paper, the authors review the literature and share their experience of the principal biological markers of fibrosis for the evaluation of periportal fibrosis (PPF) caused by mansoni schistosomiasis. These biological markers are compared to diagnostic ultrasound (US) scans as means of grading PPF. We also review procollagen type I and III, collagen type IV, laminin, hyaluronic acid (HA), immunoglobulin G, platelets, aspartate aminotransferase to platelet ratio index (APRI) and gamma-glutamyl transpeptidase as markers of the disease. Although there are several good markers for evaluating PPF and portal hypertension, such as HA, platelets or APRI, none can yet replace US. These markers may, however, be used to identify patients at greater risk of developing advanced disease in endemic areas and determine who will need further care and US studies.
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spelling Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansonischistosomiasis mansoniultrasoundfibrosis markersHS schistosomiasisliver fibrosisIn this paper, the authors review the literature and share their experience of the principal biological markers of fibrosis for the evaluation of periportal fibrosis (PPF) caused by mansoni schistosomiasis. These biological markers are compared to diagnostic ultrasound (US) scans as means of grading PPF. We also review procollagen type I and III, collagen type IV, laminin, hyaluronic acid (HA), immunoglobulin G, platelets, aspartate aminotransferase to platelet ratio index (APRI) and gamma-glutamyl transpeptidase as markers of the disease. Although there are several good markers for evaluating PPF and portal hypertension, such as HA, platelets or APRI, none can yet replace US. These markers may, however, be used to identify patients at greater risk of developing advanced disease in endemic areas and determine who will need further care and US studies.Instituto Oswaldo Cruz, Ministério da Saúde2011-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000700004Memórias do Instituto Oswaldo Cruz v.106 n.7 2011reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762011000700004info:eu-repo/semantics/openAccessDomingues,Ana Lúcia CoutinhoMedeiros,Tibério Batista deLopes,Edmundo Pessoa de Almeidaeng2020-04-25T17:51:04Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:17:52.966Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni
title Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni
spellingShingle Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni
Domingues,Ana Lúcia Coutinho
schistosomiasis mansoni
ultrasound
fibrosis markers
HS schistosomiasis
liver fibrosis
title_short Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni
title_full Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni
title_fullStr Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni
title_full_unstemmed Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni
title_sort Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni
author Domingues,Ana Lúcia Coutinho
author_facet Domingues,Ana Lúcia Coutinho
Medeiros,Tibério Batista de
Lopes,Edmundo Pessoa de Almeida
author_role author
author2 Medeiros,Tibério Batista de
Lopes,Edmundo Pessoa de Almeida
author2_role author
author
dc.contributor.author.fl_str_mv Domingues,Ana Lúcia Coutinho
Medeiros,Tibério Batista de
Lopes,Edmundo Pessoa de Almeida
dc.subject.por.fl_str_mv schistosomiasis mansoni
ultrasound
fibrosis markers
HS schistosomiasis
liver fibrosis
topic schistosomiasis mansoni
ultrasound
fibrosis markers
HS schistosomiasis
liver fibrosis
dc.description.none.fl_txt_mv In this paper, the authors review the literature and share their experience of the principal biological markers of fibrosis for the evaluation of periportal fibrosis (PPF) caused by mansoni schistosomiasis. These biological markers are compared to diagnostic ultrasound (US) scans as means of grading PPF. We also review procollagen type I and III, collagen type IV, laminin, hyaluronic acid (HA), immunoglobulin G, platelets, aspartate aminotransferase to platelet ratio index (APRI) and gamma-glutamyl transpeptidase as markers of the disease. Although there are several good markers for evaluating PPF and portal hypertension, such as HA, platelets or APRI, none can yet replace US. These markers may, however, be used to identify patients at greater risk of developing advanced disease in endemic areas and determine who will need further care and US studies.
description In this paper, the authors review the literature and share their experience of the principal biological markers of fibrosis for the evaluation of periportal fibrosis (PPF) caused by mansoni schistosomiasis. These biological markers are compared to diagnostic ultrasound (US) scans as means of grading PPF. We also review procollagen type I and III, collagen type IV, laminin, hyaluronic acid (HA), immunoglobulin G, platelets, aspartate aminotransferase to platelet ratio index (APRI) and gamma-glutamyl transpeptidase as markers of the disease. Although there are several good markers for evaluating PPF and portal hypertension, such as HA, platelets or APRI, none can yet replace US. These markers may, however, be used to identify patients at greater risk of developing advanced disease in endemic areas and determine who will need further care and US studies.
publishDate 2011
dc.date.none.fl_str_mv 2011-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000700004
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000700004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762011000700004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.106 n.7 2011
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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