Variation in the cytoadherence characteristics of malaria parasites: is this a true virulence factor?

Detalhes bibliográficos
Autor(a) principal: Goldring,J. D.
Data de Publicação: 1992
Outros Autores: Hommel,M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700053
Resumo: The sequestration of Plasmodium falciparum-infected erythrocytes to the endothelial cells of brain capillaries is believed to represent one of the determining factors in the pathogenesis of cerebral malaria. In vitro studies of cytoadherence provide an experimental approach to understand the mechanism of sequestration and the respective roles played by parasite and host components in this interaction. This paper critically reviews current studies on cytoadherence, with particular emphasis on the nature of the information provided by such studies and their limitations. The paper also describes how cytoadherence studies using the patient's own monocytes can provide original information on the level of receptor up-regulation in the course of malarial infection.
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spelling Variation in the cytoadherence characteristics of malaria parasites: is this a true virulence factor?malariacytoadherencethrombospondinICAM-1CD36monocytessequestrationcerebral malariaPlasmodium falciparumThe sequestration of Plasmodium falciparum-infected erythrocytes to the endothelial cells of brain capillaries is believed to represent one of the determining factors in the pathogenesis of cerebral malaria. In vitro studies of cytoadherence provide an experimental approach to understand the mechanism of sequestration and the respective roles played by parasite and host components in this interaction. This paper critically reviews current studies on cytoadherence, with particular emphasis on the nature of the information provided by such studies and their limitations. The paper also describes how cytoadherence studies using the patient's own monocytes can provide original information on the level of receptor up-regulation in the course of malarial infection.Instituto Oswaldo Cruz, Ministério da Saúde1992-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700053Memórias do Instituto Oswaldo Cruz v.87 suppl.3 1992reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761992000700053info:eu-repo/semantics/openAccessGoldring,J. D.Hommel,M.eng2020-04-25T17:47:00Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:05:10.994Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Variation in the cytoadherence characteristics of malaria parasites: is this a true virulence factor?
title Variation in the cytoadherence characteristics of malaria parasites: is this a true virulence factor?
spellingShingle Variation in the cytoadherence characteristics of malaria parasites: is this a true virulence factor?
Goldring,J. D.
malaria
cytoadherence
thrombospondin
ICAM-1
CD36
monocytes
sequestration
cerebral malaria
Plasmodium falciparum
title_short Variation in the cytoadherence characteristics of malaria parasites: is this a true virulence factor?
title_full Variation in the cytoadherence characteristics of malaria parasites: is this a true virulence factor?
title_fullStr Variation in the cytoadherence characteristics of malaria parasites: is this a true virulence factor?
title_full_unstemmed Variation in the cytoadherence characteristics of malaria parasites: is this a true virulence factor?
title_sort Variation in the cytoadherence characteristics of malaria parasites: is this a true virulence factor?
author Goldring,J. D.
author_facet Goldring,J. D.
Hommel,M.
author_role author
author2 Hommel,M.
author2_role author
dc.contributor.author.fl_str_mv Goldring,J. D.
Hommel,M.
dc.subject.por.fl_str_mv malaria
cytoadherence
thrombospondin
ICAM-1
CD36
monocytes
sequestration
cerebral malaria
Plasmodium falciparum
topic malaria
cytoadherence
thrombospondin
ICAM-1
CD36
monocytes
sequestration
cerebral malaria
Plasmodium falciparum
dc.description.none.fl_txt_mv The sequestration of Plasmodium falciparum-infected erythrocytes to the endothelial cells of brain capillaries is believed to represent one of the determining factors in the pathogenesis of cerebral malaria. In vitro studies of cytoadherence provide an experimental approach to understand the mechanism of sequestration and the respective roles played by parasite and host components in this interaction. This paper critically reviews current studies on cytoadherence, with particular emphasis on the nature of the information provided by such studies and their limitations. The paper also describes how cytoadherence studies using the patient's own monocytes can provide original information on the level of receptor up-regulation in the course of malarial infection.
description The sequestration of Plasmodium falciparum-infected erythrocytes to the endothelial cells of brain capillaries is believed to represent one of the determining factors in the pathogenesis of cerebral malaria. In vitro studies of cytoadherence provide an experimental approach to understand the mechanism of sequestration and the respective roles played by parasite and host components in this interaction. This paper critically reviews current studies on cytoadherence, with particular emphasis on the nature of the information provided by such studies and their limitations. The paper also describes how cytoadherence studies using the patient's own monocytes can provide original information on the level of receptor up-regulation in the course of malarial infection.
publishDate 1992
dc.date.none.fl_str_mv 1992-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700053
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700053
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761992000700053
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.87 suppl.3 1992
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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