High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000100008 |
Resumo: | Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection. |
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Memórias do Instituto Oswaldo Cruz |
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High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous cathetersbiofilmvancomycinStaphylococcus sppBiofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection.Instituto Oswaldo Cruz, Ministério da Saúde2011-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000100008Memórias do Instituto Oswaldo Cruz v.106 n.1 2011reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762011000100008info:eu-repo/semantics/openAccessAntunes,Ana Lúcia SouzaBonfanti,Jéssica WeisPerez,Leandro Reus RodriguesPinto,Camille Cattani FerreiraFreitas,Ana Lúcia Peixoto deMacedo,Alexandre JoséBarth,Afonso Luiseng2020-04-25T17:50:57Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:17:26.805Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters |
title |
High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters |
spellingShingle |
High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters Antunes,Ana Lúcia Souza biofilm vancomycin Staphylococcus spp |
title_short |
High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters |
title_full |
High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters |
title_fullStr |
High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters |
title_full_unstemmed |
High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters |
title_sort |
High vancomycin resistance among biofilms produced by Staphylococcus species isolated from central venous catheters |
author |
Antunes,Ana Lúcia Souza |
author_facet |
Antunes,Ana Lúcia Souza Bonfanti,Jéssica Weis Perez,Leandro Reus Rodrigues Pinto,Camille Cattani Ferreira Freitas,Ana Lúcia Peixoto de Macedo,Alexandre José Barth,Afonso Luis |
author_role |
author |
author2 |
Bonfanti,Jéssica Weis Perez,Leandro Reus Rodrigues Pinto,Camille Cattani Ferreira Freitas,Ana Lúcia Peixoto de Macedo,Alexandre José Barth,Afonso Luis |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Antunes,Ana Lúcia Souza Bonfanti,Jéssica Weis Perez,Leandro Reus Rodrigues Pinto,Camille Cattani Ferreira Freitas,Ana Lúcia Peixoto de Macedo,Alexandre José Barth,Afonso Luis |
dc.subject.por.fl_str_mv |
biofilm vancomycin Staphylococcus spp |
topic |
biofilm vancomycin Staphylococcus spp |
dc.description.none.fl_txt_mv |
Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection. |
description |
Biofilm production is an important mechanism that allows microbes to escape host defences and antimicrobial therapy. Vancomycin has been used largely for the treatment of methicillin-resistant staphylococcal infections. Here, we determined the minimal inhibitory concentration (MIC) and minimal biofilm eradication concentration (MBEC) for 82 Staphylococcus species isolated from central venous catheters (CVC). Our results showed that the 41 strong and moderate-biofilm-producing isolates presented a higher MBEC/MIC ratio for vancomycin than the 24 weak-biofilm-producing isolates, illustrating the importance of biofilm production ability and the difficulty in treating biofilm-related infections. The MBEC was significantly higher in moderate-biofilm-producing isolates than in weak-biofilm-producing isolates (p < 0.001) and in strong-biofilm-producing isolates than in weak-biofilm-producing isolates (p = 0.001). The correlation between the MIC and the MBEC was poor. Based on our results, we recommend that bacterial biofilms be suspected in all cases of CVC infection. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000100008 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762011000100008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762011000100008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.106 n.1 2011 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
_version_ |
1669937708868304896 |