Thymus involution in alloxan diabetes: analysis of mast cells

Detalhes bibliográficos
Autor(a) principal: Barreto,EO
Data de Publicação: 2005
Outros Autores: Riederer,I, Arantes,ACS, Carvalho,VF, Farias-Filho,FA, Cordeiro,RSB, Martins,MA, Savino,W, e Silva,PMR
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900022
Resumo: We previously reported that alloxan-induced diabetes results in reduction in the number and reactivity of mast cells at different body sites. In this study, the influence of diabetes on thymic mast cells was investigated. Thymuses from diabetic rats showed marked alterations including shrinkage, thymocyte depletion, and increase in the extracellular matrix network, as compared to those profiles seen in normal animals. Nevertheless, we noted that the number and reactivity of mast cells remained unchanged. These findings indicate that although diabetes leads to critical alterations in the thymus, the local mast cell population is refractory to its effect. This suggests that thymic mast cells are under a different regulation as compared to those located in other tissues.
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spelling Thymus involution in alloxan diabetes: analysis of mast cellsdiabetesmast cellsthymusextracellular matrixWe previously reported that alloxan-induced diabetes results in reduction in the number and reactivity of mast cells at different body sites. In this study, the influence of diabetes on thymic mast cells was investigated. Thymuses from diabetic rats showed marked alterations including shrinkage, thymocyte depletion, and increase in the extracellular matrix network, as compared to those profiles seen in normal animals. Nevertheless, we noted that the number and reactivity of mast cells remained unchanged. These findings indicate that although diabetes leads to critical alterations in the thymus, the local mast cell population is refractory to its effect. This suggests that thymic mast cells are under a different regulation as compared to those located in other tissues.Instituto Oswaldo Cruz, Ministério da Saúde2005-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900022Memórias do Instituto Oswaldo Cruz v.100 suppl.1 2005reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762005000900022info:eu-repo/semantics/openAccessBarreto,EORiederer,IArantes,ACSCarvalho,VFFarias-Filho,FACordeiro,RSBMartins,MASavino,We Silva,PMReng2020-04-25T17:49:31Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:13:32.447Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Thymus involution in alloxan diabetes: analysis of mast cells
title Thymus involution in alloxan diabetes: analysis of mast cells
spellingShingle Thymus involution in alloxan diabetes: analysis of mast cells
Barreto,EO
diabetes
mast cells
thymus
extracellular matrix
title_short Thymus involution in alloxan diabetes: analysis of mast cells
title_full Thymus involution in alloxan diabetes: analysis of mast cells
title_fullStr Thymus involution in alloxan diabetes: analysis of mast cells
title_full_unstemmed Thymus involution in alloxan diabetes: analysis of mast cells
title_sort Thymus involution in alloxan diabetes: analysis of mast cells
author Barreto,EO
author_facet Barreto,EO
Riederer,I
Arantes,ACS
Carvalho,VF
Farias-Filho,FA
Cordeiro,RSB
Martins,MA
Savino,W
e Silva,PMR
author_role author
author2 Riederer,I
Arantes,ACS
Carvalho,VF
Farias-Filho,FA
Cordeiro,RSB
Martins,MA
Savino,W
e Silva,PMR
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Barreto,EO
Riederer,I
Arantes,ACS
Carvalho,VF
Farias-Filho,FA
Cordeiro,RSB
Martins,MA
Savino,W
e Silva,PMR
dc.subject.por.fl_str_mv diabetes
mast cells
thymus
extracellular matrix
topic diabetes
mast cells
thymus
extracellular matrix
dc.description.none.fl_txt_mv We previously reported that alloxan-induced diabetes results in reduction in the number and reactivity of mast cells at different body sites. In this study, the influence of diabetes on thymic mast cells was investigated. Thymuses from diabetic rats showed marked alterations including shrinkage, thymocyte depletion, and increase in the extracellular matrix network, as compared to those profiles seen in normal animals. Nevertheless, we noted that the number and reactivity of mast cells remained unchanged. These findings indicate that although diabetes leads to critical alterations in the thymus, the local mast cell population is refractory to its effect. This suggests that thymic mast cells are under a different regulation as compared to those located in other tissues.
description We previously reported that alloxan-induced diabetes results in reduction in the number and reactivity of mast cells at different body sites. In this study, the influence of diabetes on thymic mast cells was investigated. Thymuses from diabetic rats showed marked alterations including shrinkage, thymocyte depletion, and increase in the extracellular matrix network, as compared to those profiles seen in normal animals. Nevertheless, we noted that the number and reactivity of mast cells remained unchanged. These findings indicate that although diabetes leads to critical alterations in the thymus, the local mast cell population is refractory to its effect. This suggests that thymic mast cells are under a different regulation as compared to those located in other tissues.
publishDate 2005
dc.date.none.fl_str_mv 2005-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900022
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000900022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762005000900022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.100 suppl.1 2005
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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