New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000900587 |
Resumo: | BACKGROUND The link between Candida albicans and diabetes mellitus is well-acknowledged, but incompletely elucidated. OBJECTIVES The purpose of this study is to assess the growth rate of C. albicans (CA) in the presence of different concentrations of glucose and fructose, two of the main pathophysiologic and nutritionally relevant sugars in diabetic patients, in order to obtain a better understanding of the nutrient acquisition strategy and its possible relation to the hyperglycemic status of diabetic patients. METHODS The effects of different concentrations of glucose and fructose (1000 mg%, 500 mg%, 250 mg% and 100 mg% w/v) on the growth rate of CA have been studied by flow-cytometry. FINDINGS We found that glucose concentration is directly related to CA growth, which may be linked to the frequent yeast infections that occur in non-controlled diabetic patients; we also show that fructose inhibits CA growth rate. MAIN CONCLUSIONS As a consequence of our hypothesis, the study demonstrates that fructose-containing food may prevent the development of candidiasis, at least in oral sites. |
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Memórias do Instituto Oswaldo Cruz |
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New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro studyCandida albicansdiabetesyeast infectionsfructoseflow-cytometryglycemic control BACKGROUND The link between Candida albicans and diabetes mellitus is well-acknowledged, but incompletely elucidated. OBJECTIVES The purpose of this study is to assess the growth rate of C. albicans (CA) in the presence of different concentrations of glucose and fructose, two of the main pathophysiologic and nutritionally relevant sugars in diabetic patients, in order to obtain a better understanding of the nutrient acquisition strategy and its possible relation to the hyperglycemic status of diabetic patients. METHODS The effects of different concentrations of glucose and fructose (1000 mg%, 500 mg%, 250 mg% and 100 mg% w/v) on the growth rate of CA have been studied by flow-cytometry. FINDINGS We found that glucose concentration is directly related to CA growth, which may be linked to the frequent yeast infections that occur in non-controlled diabetic patients; we also show that fructose inhibits CA growth rate. MAIN CONCLUSIONS As a consequence of our hypothesis, the study demonstrates that fructose-containing food may prevent the development of candidiasis, at least in oral sites.Instituto Oswaldo Cruz, Ministério da Saúde2017-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000900587Memórias do Instituto Oswaldo Cruz v.112 n.9 2017reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-02760170098info:eu-repo/semantics/openAccessMan,AdrianCiurea,Cristina NicoletaPasaroiu,DanSavin,Ana-IoanaToma,FeliciaSular,FloredanaSantacroce,LuigiMare,Ancaeng2020-04-25T17:52:39Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:21:48.376Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study |
title |
New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study |
spellingShingle |
New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study Man,Adrian Candida albicans diabetes yeast infections fructose flow-cytometry glycemic control |
title_short |
New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study |
title_full |
New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study |
title_fullStr |
New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study |
title_full_unstemmed |
New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study |
title_sort |
New perspectives on the nutritional factors influencing growth rate of Candida albicans in diabetics. An in vitro study |
author |
Man,Adrian |
author_facet |
Man,Adrian Ciurea,Cristina Nicoleta Pasaroiu,Dan Savin,Ana-Ioana Toma,Felicia Sular,Floredana Santacroce,Luigi Mare,Anca |
author_role |
author |
author2 |
Ciurea,Cristina Nicoleta Pasaroiu,Dan Savin,Ana-Ioana Toma,Felicia Sular,Floredana Santacroce,Luigi Mare,Anca |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Man,Adrian Ciurea,Cristina Nicoleta Pasaroiu,Dan Savin,Ana-Ioana Toma,Felicia Sular,Floredana Santacroce,Luigi Mare,Anca |
dc.subject.por.fl_str_mv |
Candida albicans diabetes yeast infections fructose flow-cytometry glycemic control |
topic |
Candida albicans diabetes yeast infections fructose flow-cytometry glycemic control |
dc.description.none.fl_txt_mv |
BACKGROUND The link between Candida albicans and diabetes mellitus is well-acknowledged, but incompletely elucidated. OBJECTIVES The purpose of this study is to assess the growth rate of C. albicans (CA) in the presence of different concentrations of glucose and fructose, two of the main pathophysiologic and nutritionally relevant sugars in diabetic patients, in order to obtain a better understanding of the nutrient acquisition strategy and its possible relation to the hyperglycemic status of diabetic patients. METHODS The effects of different concentrations of glucose and fructose (1000 mg%, 500 mg%, 250 mg% and 100 mg% w/v) on the growth rate of CA have been studied by flow-cytometry. FINDINGS We found that glucose concentration is directly related to CA growth, which may be linked to the frequent yeast infections that occur in non-controlled diabetic patients; we also show that fructose inhibits CA growth rate. MAIN CONCLUSIONS As a consequence of our hypothesis, the study demonstrates that fructose-containing food may prevent the development of candidiasis, at least in oral sites. |
description |
BACKGROUND The link between Candida albicans and diabetes mellitus is well-acknowledged, but incompletely elucidated. OBJECTIVES The purpose of this study is to assess the growth rate of C. albicans (CA) in the presence of different concentrations of glucose and fructose, two of the main pathophysiologic and nutritionally relevant sugars in diabetic patients, in order to obtain a better understanding of the nutrient acquisition strategy and its possible relation to the hyperglycemic status of diabetic patients. METHODS The effects of different concentrations of glucose and fructose (1000 mg%, 500 mg%, 250 mg% and 100 mg% w/v) on the growth rate of CA have been studied by flow-cytometry. FINDINGS We found that glucose concentration is directly related to CA growth, which may be linked to the frequent yeast infections that occur in non-controlled diabetic patients; we also show that fructose inhibits CA growth rate. MAIN CONCLUSIONS As a consequence of our hypothesis, the study demonstrates that fructose-containing food may prevent the development of candidiasis, at least in oral sites. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000900587 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762017000900587 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0074-02760170098 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.112 n.9 2017 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
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1669937724089434112 |