DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients

Detalhes bibliográficos
Autor(a) principal: Segat,Ludovica
Data de Publicação: 2014
Outros Autores: Zupin,Luisa, Moura,Ronald Rodrigues, Coelho,Antonio Victor Campos, Chagas,Bárbara Simas, Freitas,Antonio Carlos de, Crovella,Sergio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700918
Resumo: The human beta defensin 1 (hBD-1) antimicrobial peptide is a member of the innate immune system known to act in the first line of defence against microorganisms, including viruses such as human papillomavirus (HPV). In this study, five functional polymorphisms (namely g-52G>A, g-44C>G and g-20G>A in the 5’UTR and c.*5G>A and c.*87A>G in the 3’UTR) in the DEFB1 gene encoding for hBD-1 were analysed to investigate the possible involvement of these genetic variants in susceptibility to HPV infection and in the development of HPV-associated lesions in a population of Brazilian women. The DEFB1 g-52G>A and c.*5G>A single-nucleotide polymorphisms (SNPs) and the GCAAA haplotype showed associations with HPV-negative status; in particular, the c.*5G>A SNP was significantly associated after multiple test corrections. These findings suggest a possible role for the constitutively expressed beta defensin-1 peptide as a natural defence against HPV in the genital tract mucosa.
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spelling DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patientsantimicrobial peptideshuman papillomavirusgenetic polymorphismscervical lesionThe human beta defensin 1 (hBD-1) antimicrobial peptide is a member of the innate immune system known to act in the first line of defence against microorganisms, including viruses such as human papillomavirus (HPV). In this study, five functional polymorphisms (namely g-52G>A, g-44C>G and g-20G>A in the 5’UTR and c.*5G>A and c.*87A>G in the 3’UTR) in the DEFB1 gene encoding for hBD-1 were analysed to investigate the possible involvement of these genetic variants in susceptibility to HPV infection and in the development of HPV-associated lesions in a population of Brazilian women. The DEFB1 g-52G>A and c.*5G>A single-nucleotide polymorphisms (SNPs) and the GCAAA haplotype showed associations with HPV-negative status; in particular, the c.*5G>A SNP was significantly associated after multiple test corrections. These findings suggest a possible role for the constitutively expressed beta defensin-1 peptide as a natural defence against HPV in the genital tract mucosa.Instituto Oswaldo Cruz, Ministério da Saúde2014-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700918Memórias do Instituto Oswaldo Cruz v.109 n.7 2014reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-0276140220info:eu-repo/semantics/openAccessSegat,LudovicaZupin,LuisaMoura,Ronald RodriguesCoelho,Antonio Victor CamposChagas,Bárbara SimasFreitas,Antonio Carlos deCrovella,Sergioeng2020-04-25T17:51:48Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:19:53.222Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients
title DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients
spellingShingle DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients
Segat,Ludovica
antimicrobial peptides
human papillomavirus
genetic polymorphisms
cervical lesion
title_short DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients
title_full DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients
title_fullStr DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients
title_full_unstemmed DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients
title_sort DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients
author Segat,Ludovica
author_facet Segat,Ludovica
Zupin,Luisa
Moura,Ronald Rodrigues
Coelho,Antonio Victor Campos
Chagas,Bárbara Simas
Freitas,Antonio Carlos de
Crovella,Sergio
author_role author
author2 Zupin,Luisa
Moura,Ronald Rodrigues
Coelho,Antonio Victor Campos
Chagas,Bárbara Simas
Freitas,Antonio Carlos de
Crovella,Sergio
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Segat,Ludovica
Zupin,Luisa
Moura,Ronald Rodrigues
Coelho,Antonio Victor Campos
Chagas,Bárbara Simas
Freitas,Antonio Carlos de
Crovella,Sergio
dc.subject.por.fl_str_mv antimicrobial peptides
human papillomavirus
genetic polymorphisms
cervical lesion
topic antimicrobial peptides
human papillomavirus
genetic polymorphisms
cervical lesion
dc.description.none.fl_txt_mv The human beta defensin 1 (hBD-1) antimicrobial peptide is a member of the innate immune system known to act in the first line of defence against microorganisms, including viruses such as human papillomavirus (HPV). In this study, five functional polymorphisms (namely g-52G>A, g-44C>G and g-20G>A in the 5’UTR and c.*5G>A and c.*87A>G in the 3’UTR) in the DEFB1 gene encoding for hBD-1 were analysed to investigate the possible involvement of these genetic variants in susceptibility to HPV infection and in the development of HPV-associated lesions in a population of Brazilian women. The DEFB1 g-52G>A and c.*5G>A single-nucleotide polymorphisms (SNPs) and the GCAAA haplotype showed associations with HPV-negative status; in particular, the c.*5G>A SNP was significantly associated after multiple test corrections. These findings suggest a possible role for the constitutively expressed beta defensin-1 peptide as a natural defence against HPV in the genital tract mucosa.
description The human beta defensin 1 (hBD-1) antimicrobial peptide is a member of the innate immune system known to act in the first line of defence against microorganisms, including viruses such as human papillomavirus (HPV). In this study, five functional polymorphisms (namely g-52G>A, g-44C>G and g-20G>A in the 5’UTR and c.*5G>A and c.*87A>G in the 3’UTR) in the DEFB1 gene encoding for hBD-1 were analysed to investigate the possible involvement of these genetic variants in susceptibility to HPV infection and in the development of HPV-associated lesions in a population of Brazilian women. The DEFB1 g-52G>A and c.*5G>A single-nucleotide polymorphisms (SNPs) and the GCAAA haplotype showed associations with HPV-negative status; in particular, the c.*5G>A SNP was significantly associated after multiple test corrections. These findings suggest a possible role for the constitutively expressed beta defensin-1 peptide as a natural defence against HPV in the genital tract mucosa.
publishDate 2014
dc.date.none.fl_str_mv 2014-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700918
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700918
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0074-0276140220
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.109 n.7 2014
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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