DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700918 |
Resumo: | The human beta defensin 1 (hBD-1) antimicrobial peptide is a member of the innate immune system known to act in the first line of defence against microorganisms, including viruses such as human papillomavirus (HPV). In this study, five functional polymorphisms (namely g-52G>A, g-44C>G and g-20G>A in the 5’UTR and c.*5G>A and c.*87A>G in the 3’UTR) in the DEFB1 gene encoding for hBD-1 were analysed to investigate the possible involvement of these genetic variants in susceptibility to HPV infection and in the development of HPV-associated lesions in a population of Brazilian women. The DEFB1 g-52G>A and c.*5G>A single-nucleotide polymorphisms (SNPs) and the GCAAA haplotype showed associations with HPV-negative status; in particular, the c.*5G>A SNP was significantly associated after multiple test corrections. These findings suggest a possible role for the constitutively expressed beta defensin-1 peptide as a natural defence against HPV in the genital tract mucosa. |
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Memórias do Instituto Oswaldo Cruz |
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DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patientsantimicrobial peptideshuman papillomavirusgenetic polymorphismscervical lesionThe human beta defensin 1 (hBD-1) antimicrobial peptide is a member of the innate immune system known to act in the first line of defence against microorganisms, including viruses such as human papillomavirus (HPV). In this study, five functional polymorphisms (namely g-52G>A, g-44C>G and g-20G>A in the 5’UTR and c.*5G>A and c.*87A>G in the 3’UTR) in the DEFB1 gene encoding for hBD-1 were analysed to investigate the possible involvement of these genetic variants in susceptibility to HPV infection and in the development of HPV-associated lesions in a population of Brazilian women. The DEFB1 g-52G>A and c.*5G>A single-nucleotide polymorphisms (SNPs) and the GCAAA haplotype showed associations with HPV-negative status; in particular, the c.*5G>A SNP was significantly associated after multiple test corrections. These findings suggest a possible role for the constitutively expressed beta defensin-1 peptide as a natural defence against HPV in the genital tract mucosa.Instituto Oswaldo Cruz, Ministério da Saúde2014-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700918Memórias do Instituto Oswaldo Cruz v.109 n.7 2014reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/0074-0276140220info:eu-repo/semantics/openAccessSegat,LudovicaZupin,LuisaMoura,Ronald RodriguesCoelho,Antonio Victor CamposChagas,Bárbara SimasFreitas,Antonio Carlos deCrovella,Sergioeng2020-04-25T17:51:48Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:19:53.222Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients |
title |
DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients |
spellingShingle |
DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients Segat,Ludovica antimicrobial peptides human papillomavirus genetic polymorphisms cervical lesion |
title_short |
DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients |
title_full |
DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients |
title_fullStr |
DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients |
title_full_unstemmed |
DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients |
title_sort |
DEFB1 polymorphisms are involved in susceptibility to human papillomavirus infection in Brazilian gynaecological patients |
author |
Segat,Ludovica |
author_facet |
Segat,Ludovica Zupin,Luisa Moura,Ronald Rodrigues Coelho,Antonio Victor Campos Chagas,Bárbara Simas Freitas,Antonio Carlos de Crovella,Sergio |
author_role |
author |
author2 |
Zupin,Luisa Moura,Ronald Rodrigues Coelho,Antonio Victor Campos Chagas,Bárbara Simas Freitas,Antonio Carlos de Crovella,Sergio |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Segat,Ludovica Zupin,Luisa Moura,Ronald Rodrigues Coelho,Antonio Victor Campos Chagas,Bárbara Simas Freitas,Antonio Carlos de Crovella,Sergio |
dc.subject.por.fl_str_mv |
antimicrobial peptides human papillomavirus genetic polymorphisms cervical lesion |
topic |
antimicrobial peptides human papillomavirus genetic polymorphisms cervical lesion |
dc.description.none.fl_txt_mv |
The human beta defensin 1 (hBD-1) antimicrobial peptide is a member of the innate immune system known to act in the first line of defence against microorganisms, including viruses such as human papillomavirus (HPV). In this study, five functional polymorphisms (namely g-52G>A, g-44C>G and g-20G>A in the 5’UTR and c.*5G>A and c.*87A>G in the 3’UTR) in the DEFB1 gene encoding for hBD-1 were analysed to investigate the possible involvement of these genetic variants in susceptibility to HPV infection and in the development of HPV-associated lesions in a population of Brazilian women. The DEFB1 g-52G>A and c.*5G>A single-nucleotide polymorphisms (SNPs) and the GCAAA haplotype showed associations with HPV-negative status; in particular, the c.*5G>A SNP was significantly associated after multiple test corrections. These findings suggest a possible role for the constitutively expressed beta defensin-1 peptide as a natural defence against HPV in the genital tract mucosa. |
description |
The human beta defensin 1 (hBD-1) antimicrobial peptide is a member of the innate immune system known to act in the first line of defence against microorganisms, including viruses such as human papillomavirus (HPV). In this study, five functional polymorphisms (namely g-52G>A, g-44C>G and g-20G>A in the 5’UTR and c.*5G>A and c.*87A>G in the 3’UTR) in the DEFB1 gene encoding for hBD-1 were analysed to investigate the possible involvement of these genetic variants in susceptibility to HPV infection and in the development of HPV-associated lesions in a population of Brazilian women. The DEFB1 g-52G>A and c.*5G>A single-nucleotide polymorphisms (SNPs) and the GCAAA haplotype showed associations with HPV-negative status; in particular, the c.*5G>A SNP was significantly associated after multiple test corrections. These findings suggest a possible role for the constitutively expressed beta defensin-1 peptide as a natural defence against HPV in the genital tract mucosa. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-11-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700918 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700918 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0074-0276140220 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.109 n.7 2014 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
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1669937716958068736 |