Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection

Detalhes bibliográficos
Autor(a) principal: Kojima,Somei
Data de Publicação: 1987
Outros Autores: Janecharut,Tuenta, Hata,Hidekazu, Niimura,Munetoshi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800045
Resumo: We have been able to produce a mouse monoclonal IgE antibody specific to an adult worm antigen extracted from Schistosoma japonicum (Sj). The antibody was able to elicit passive cutaneous anaphylaxis in the rat skin against Sj with the highest titer of 1:256,000 but did not cross-react with S. mansoni antigen. The antibody recognized a 97-kDa molecule expressed on the surface of mechanically transformed schistosoma of S. japonicum. Passive transfer of the antibody into mice in the early stage of challenge infection resulted in a partial but significant reduction of recovery of adult worms. Induction of eosinophilia by an oral administration of embryonated eggs of Toxocara canis prior to challenge infection enhanced the reduction.
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spelling Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infectionWe have been able to produce a mouse monoclonal IgE antibody specific to an adult worm antigen extracted from Schistosoma japonicum (Sj). The antibody was able to elicit passive cutaneous anaphylaxis in the rat skin against Sj with the highest titer of 1:256,000 but did not cross-react with S. mansoni antigen. The antibody recognized a 97-kDa molecule expressed on the surface of mechanically transformed schistosoma of S. japonicum. Passive transfer of the antibody into mice in the early stage of challenge infection resulted in a partial but significant reduction of recovery of adult worms. Induction of eosinophilia by an oral administration of embryonated eggs of Toxocara canis prior to challenge infection enhanced the reduction.Instituto Oswaldo Cruz, Ministério da Saúde1987-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800045Memórias do Instituto Oswaldo Cruz v.82 suppl.4 1987reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761987000800045info:eu-repo/semantics/openAccessKojima,SomeiJanecharut,TuentaHata,HidekazuNiimura,Munetoshieng2020-04-25T17:46:02Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:02:13.598Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection
title Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection
spellingShingle Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection
Kojima,Somei
title_short Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection
title_full Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection
title_fullStr Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection
title_full_unstemmed Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection
title_sort Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection
author Kojima,Somei
author_facet Kojima,Somei
Janecharut,Tuenta
Hata,Hidekazu
Niimura,Munetoshi
author_role author
author2 Janecharut,Tuenta
Hata,Hidekazu
Niimura,Munetoshi
author2_role author
author
author
dc.contributor.author.fl_str_mv Kojima,Somei
Janecharut,Tuenta
Hata,Hidekazu
Niimura,Munetoshi
dc.description.none.fl_txt_mv We have been able to produce a mouse monoclonal IgE antibody specific to an adult worm antigen extracted from Schistosoma japonicum (Sj). The antibody was able to elicit passive cutaneous anaphylaxis in the rat skin against Sj with the highest titer of 1:256,000 but did not cross-react with S. mansoni antigen. The antibody recognized a 97-kDa molecule expressed on the surface of mechanically transformed schistosoma of S. japonicum. Passive transfer of the antibody into mice in the early stage of challenge infection resulted in a partial but significant reduction of recovery of adult worms. Induction of eosinophilia by an oral administration of embryonated eggs of Toxocara canis prior to challenge infection enhanced the reduction.
description We have been able to produce a mouse monoclonal IgE antibody specific to an adult worm antigen extracted from Schistosoma japonicum (Sj). The antibody was able to elicit passive cutaneous anaphylaxis in the rat skin against Sj with the highest titer of 1:256,000 but did not cross-react with S. mansoni antigen. The antibody recognized a 97-kDa molecule expressed on the surface of mechanically transformed schistosoma of S. japonicum. Passive transfer of the antibody into mice in the early stage of challenge infection resulted in a partial but significant reduction of recovery of adult worms. Induction of eosinophilia by an oral administration of embryonated eggs of Toxocara canis prior to challenge infection enhanced the reduction.
publishDate 1987
dc.date.none.fl_str_mv 1987-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800045
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800045
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761987000800045
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.82 suppl.4 1987
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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