Treatment of postmenopausal osteoporosis in women: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Cadernos de Saúde Pública |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2008001600011 |
Resumo: | Osteoporosis, a typical disease of the elderly, has become a frequent and relevant public health problem. Several drugs are available for treatment of osteoporosis, some of which are currently dispensed by the Brazilian Unified National Health System. The objective of this study was to present a systematic review of drugs for treatment of osteoporosis, focusing on the adequacy of clinical protocols based on existing evidence in the scientific literature. We conducted a search for randomized clinical trials in PubMed and LILACS that presented results for bone mineral density, incidence of vertebral fractures, and adverse effects. 32 articles met the review's inclusion criteria. Bisphosphonates were reported to have consistently reduced the risk of vertebral fractures. Hormone replacement therapy showed positive outcomes, but its use has been found to increase the risk of cardiovascular disease and breast cancer. Teriparatide and monofluorophosphate also showed efficacy against osteoporosis. Calcium and vitamin D were given to patients as food supplements. |
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Treatment of postmenopausal osteoporosis in women: a systematic reviewPostmenopausal OsteoporosisDrugsWomen's HealthIntroductionOsteoporosis, a typical disease of the elderly, has become a frequent and relevant public health problem. Several drugs are available for treatment of osteoporosis, some of which are currently dispensed by the Brazilian Unified National Health System. The objective of this study was to present a systematic review of drugs for treatment of osteoporosis, focusing on the adequacy of clinical protocols based on existing evidence in the scientific literature. We conducted a search for randomized clinical trials in PubMed and LILACS that presented results for bone mineral density, incidence of vertebral fractures, and adverse effects. 32 articles met the review's inclusion criteria. Bisphosphonates were reported to have consistently reduced the risk of vertebral fractures. Hormone replacement therapy showed positive outcomes, but its use has been found to increase the risk of cardiovascular disease and breast cancer. Teriparatide and monofluorophosphate also showed efficacy against osteoporosis. Calcium and vitamin D were given to patients as food supplements.Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2008001600011Cadernos de Saúde Pública v.24 suppl.4 2008reponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZ10.1590/S0102-311X2008001600011info:eu-repo/semantics/openAccessBrandão,Cristina Mariano RuasLima,Marina GuimarãesSilva,Anderson Lourenço daSilva,Graziele DiasGuerra Jr.,Augusto AfonsoAcúrcio,Francisco de Assiseng2008-09-03T00:00:00Zoai:scielo:S0102-311X2008001600011Revistahttp://cadernos.ensp.fiocruz.br/csp/https://old.scielo.br/oai/scielo-oai.phpcadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2008-09-03T00:00Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.none.fl_str_mv |
Treatment of postmenopausal osteoporosis in women: a systematic review |
title |
Treatment of postmenopausal osteoporosis in women: a systematic review |
spellingShingle |
Treatment of postmenopausal osteoporosis in women: a systematic review Brandão,Cristina Mariano Ruas Postmenopausal Osteoporosis Drugs Women's HealthIntroduction |
title_short |
Treatment of postmenopausal osteoporosis in women: a systematic review |
title_full |
Treatment of postmenopausal osteoporosis in women: a systematic review |
title_fullStr |
Treatment of postmenopausal osteoporosis in women: a systematic review |
title_full_unstemmed |
Treatment of postmenopausal osteoporosis in women: a systematic review |
title_sort |
Treatment of postmenopausal osteoporosis in women: a systematic review |
author |
Brandão,Cristina Mariano Ruas |
author_facet |
Brandão,Cristina Mariano Ruas Lima,Marina Guimarães Silva,Anderson Lourenço da Silva,Graziele Dias Guerra Jr.,Augusto Afonso Acúrcio,Francisco de Assis |
author_role |
author |
author2 |
Lima,Marina Guimarães Silva,Anderson Lourenço da Silva,Graziele Dias Guerra Jr.,Augusto Afonso Acúrcio,Francisco de Assis |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Brandão,Cristina Mariano Ruas Lima,Marina Guimarães Silva,Anderson Lourenço da Silva,Graziele Dias Guerra Jr.,Augusto Afonso Acúrcio,Francisco de Assis |
dc.subject.por.fl_str_mv |
Postmenopausal Osteoporosis Drugs Women's HealthIntroduction |
topic |
Postmenopausal Osteoporosis Drugs Women's HealthIntroduction |
description |
Osteoporosis, a typical disease of the elderly, has become a frequent and relevant public health problem. Several drugs are available for treatment of osteoporosis, some of which are currently dispensed by the Brazilian Unified National Health System. The objective of this study was to present a systematic review of drugs for treatment of osteoporosis, focusing on the adequacy of clinical protocols based on existing evidence in the scientific literature. We conducted a search for randomized clinical trials in PubMed and LILACS that presented results for bone mineral density, incidence of vertebral fractures, and adverse effects. 32 articles met the review's inclusion criteria. Bisphosphonates were reported to have consistently reduced the risk of vertebral fractures. Hormone replacement therapy showed positive outcomes, but its use has been found to increase the risk of cardiovascular disease and breast cancer. Teriparatide and monofluorophosphate also showed efficacy against osteoporosis. Calcium and vitamin D were given to patients as food supplements. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2008001600011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2008001600011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-311X2008001600011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz |
publisher.none.fl_str_mv |
Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz |
dc.source.none.fl_str_mv |
Cadernos de Saúde Pública v.24 suppl.4 2008 reponame:Cadernos de Saúde Pública instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Cadernos de Saúde Pública |
collection |
Cadernos de Saúde Pública |
repository.name.fl_str_mv |
Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br |
_version_ |
1754115728614621184 |