Treatment of postmenopausal osteoporosis in women: a systematic review

Detalhes bibliográficos
Autor(a) principal: Brandão,Cristina Mariano Ruas
Data de Publicação: 2008
Outros Autores: Lima,Marina Guimarães, Silva,Anderson Lourenço da, Silva,Graziele Dias, Guerra Jr.,Augusto Afonso, Acúrcio,Francisco de Assis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2008001600011
Resumo: Osteoporosis, a typical disease of the elderly, has become a frequent and relevant public health problem. Several drugs are available for treatment of osteoporosis, some of which are currently dispensed by the Brazilian Unified National Health System. The objective of this study was to present a systematic review of drugs for treatment of osteoporosis, focusing on the adequacy of clinical protocols based on existing evidence in the scientific literature. We conducted a search for randomized clinical trials in PubMed and LILACS that presented results for bone mineral density, incidence of vertebral fractures, and adverse effects. 32 articles met the review's inclusion criteria. Bisphosphonates were reported to have consistently reduced the risk of vertebral fractures. Hormone replacement therapy showed positive outcomes, but its use has been found to increase the risk of cardiovascular disease and breast cancer. Teriparatide and monofluorophosphate also showed efficacy against osteoporosis. Calcium and vitamin D were given to patients as food supplements.
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spelling Treatment of postmenopausal osteoporosis in women: a systematic reviewPostmenopausal OsteoporosisDrugsWomen's HealthIntroductionOsteoporosis, a typical disease of the elderly, has become a frequent and relevant public health problem. Several drugs are available for treatment of osteoporosis, some of which are currently dispensed by the Brazilian Unified National Health System. The objective of this study was to present a systematic review of drugs for treatment of osteoporosis, focusing on the adequacy of clinical protocols based on existing evidence in the scientific literature. We conducted a search for randomized clinical trials in PubMed and LILACS that presented results for bone mineral density, incidence of vertebral fractures, and adverse effects. 32 articles met the review's inclusion criteria. Bisphosphonates were reported to have consistently reduced the risk of vertebral fractures. Hormone replacement therapy showed positive outcomes, but its use has been found to increase the risk of cardiovascular disease and breast cancer. Teriparatide and monofluorophosphate also showed efficacy against osteoporosis. Calcium and vitamin D were given to patients as food supplements.Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2008001600011Cadernos de Saúde Pública v.24 suppl.4 2008reponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZ10.1590/S0102-311X2008001600011info:eu-repo/semantics/openAccessBrandão,Cristina Mariano RuasLima,Marina GuimarãesSilva,Anderson Lourenço daSilva,Graziele DiasGuerra Jr.,Augusto AfonsoAcúrcio,Francisco de Assiseng2008-09-03T00:00:00Zoai:scielo:S0102-311X2008001600011Revistahttp://cadernos.ensp.fiocruz.br/csp/https://old.scielo.br/oai/scielo-oai.phpcadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2008-09-03T00:00Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Treatment of postmenopausal osteoporosis in women: a systematic review
title Treatment of postmenopausal osteoporosis in women: a systematic review
spellingShingle Treatment of postmenopausal osteoporosis in women: a systematic review
Brandão,Cristina Mariano Ruas
Postmenopausal Osteoporosis
Drugs
Women's HealthIntroduction
title_short Treatment of postmenopausal osteoporosis in women: a systematic review
title_full Treatment of postmenopausal osteoporosis in women: a systematic review
title_fullStr Treatment of postmenopausal osteoporosis in women: a systematic review
title_full_unstemmed Treatment of postmenopausal osteoporosis in women: a systematic review
title_sort Treatment of postmenopausal osteoporosis in women: a systematic review
author Brandão,Cristina Mariano Ruas
author_facet Brandão,Cristina Mariano Ruas
Lima,Marina Guimarães
Silva,Anderson Lourenço da
Silva,Graziele Dias
Guerra Jr.,Augusto Afonso
Acúrcio,Francisco de Assis
author_role author
author2 Lima,Marina Guimarães
Silva,Anderson Lourenço da
Silva,Graziele Dias
Guerra Jr.,Augusto Afonso
Acúrcio,Francisco de Assis
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Brandão,Cristina Mariano Ruas
Lima,Marina Guimarães
Silva,Anderson Lourenço da
Silva,Graziele Dias
Guerra Jr.,Augusto Afonso
Acúrcio,Francisco de Assis
dc.subject.por.fl_str_mv Postmenopausal Osteoporosis
Drugs
Women's HealthIntroduction
topic Postmenopausal Osteoporosis
Drugs
Women's HealthIntroduction
description Osteoporosis, a typical disease of the elderly, has become a frequent and relevant public health problem. Several drugs are available for treatment of osteoporosis, some of which are currently dispensed by the Brazilian Unified National Health System. The objective of this study was to present a systematic review of drugs for treatment of osteoporosis, focusing on the adequacy of clinical protocols based on existing evidence in the scientific literature. We conducted a search for randomized clinical trials in PubMed and LILACS that presented results for bone mineral density, incidence of vertebral fractures, and adverse effects. 32 articles met the review's inclusion criteria. Bisphosphonates were reported to have consistently reduced the risk of vertebral fractures. Hormone replacement therapy showed positive outcomes, but its use has been found to increase the risk of cardiovascular disease and breast cancer. Teriparatide and monofluorophosphate also showed efficacy against osteoporosis. Calcium and vitamin D were given to patients as food supplements.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2008001600011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2008001600011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-311X2008001600011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
publisher.none.fl_str_mv Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
dc.source.none.fl_str_mv Cadernos de Saúde Pública v.24 suppl.4 2008
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br
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