Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results

Detalhes bibliográficos
Autor(a) principal: Braga,Cynthia
Data de Publicação: 2016
Outros Autores: Albuquerque,Maria de Fátima Pessoa Militão de, Cordeiro,Marli Tenório, Castanha,Priscila M. S., Ramesh,Anita, Alexander,Neal, Mello,Maria Júlia G. de, Marques Jr,Ernesto T. A., Martelli,Celina M. Turchi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2016000100601
Resumo: Abstract Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Pernambuco State, Brazil, to determine the incidence of serotype-specific dengue infection and the kinetics of transferred maternal anti-dengue antibodies in the first years of life. This article describes the design, methods and preliminary results of this cohort study. 354 children underwent clinical and laboratory monitoring for two years, with 15% losses to follow-up. The overall rate of new infections was approximately 10% in the first year of follow-up. Information on the force of serotype-specific dengue infection and the evaluation of transferred maternal antibodies can contribute to understanding dengue etiopathogenesis.
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spelling Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary resultsPassive ImmunizationDengueCohort StudiesAbstract Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Pernambuco State, Brazil, to determine the incidence of serotype-specific dengue infection and the kinetics of transferred maternal anti-dengue antibodies in the first years of life. This article describes the design, methods and preliminary results of this cohort study. 354 children underwent clinical and laboratory monitoring for two years, with 15% losses to follow-up. The overall rate of new infections was approximately 10% in the first year of follow-up. Information on the force of serotype-specific dengue infection and the evaluation of transferred maternal antibodies can contribute to understanding dengue etiopathogenesis.Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz2016-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2016000100601Cadernos de Saúde Pública v.32 n.1 2016reponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZ10.1590/0102-311X00095815info:eu-repo/semantics/openAccessBraga,CynthiaAlbuquerque,Maria de Fátima Pessoa Militão deCordeiro,Marli TenórioCastanha,Priscila M. S.Ramesh,AnitaAlexander,NealMello,Maria Júlia G. deMarques Jr,Ernesto T. A.Martelli,Celina M. Turchieng2016-02-03T00:00:00Zoai:scielo:S0102-311X2016000100601Revistahttp://cadernos.ensp.fiocruz.br/csp/https://old.scielo.br/oai/scielo-oai.phpcadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2016-02-03T00:00Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results
title Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results
spellingShingle Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results
Braga,Cynthia
Passive Immunization
Dengue
Cohort Studies
title_short Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results
title_full Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results
title_fullStr Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results
title_full_unstemmed Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results
title_sort Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results
author Braga,Cynthia
author_facet Braga,Cynthia
Albuquerque,Maria de Fátima Pessoa Militão de
Cordeiro,Marli Tenório
Castanha,Priscila M. S.
Ramesh,Anita
Alexander,Neal
Mello,Maria Júlia G. de
Marques Jr,Ernesto T. A.
Martelli,Celina M. Turchi
author_role author
author2 Albuquerque,Maria de Fátima Pessoa Militão de
Cordeiro,Marli Tenório
Castanha,Priscila M. S.
Ramesh,Anita
Alexander,Neal
Mello,Maria Júlia G. de
Marques Jr,Ernesto T. A.
Martelli,Celina M. Turchi
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Braga,Cynthia
Albuquerque,Maria de Fátima Pessoa Militão de
Cordeiro,Marli Tenório
Castanha,Priscila M. S.
Ramesh,Anita
Alexander,Neal
Mello,Maria Júlia G. de
Marques Jr,Ernesto T. A.
Martelli,Celina M. Turchi
dc.subject.por.fl_str_mv Passive Immunization
Dengue
Cohort Studies
topic Passive Immunization
Dengue
Cohort Studies
description Abstract Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Pernambuco State, Brazil, to determine the incidence of serotype-specific dengue infection and the kinetics of transferred maternal anti-dengue antibodies in the first years of life. This article describes the design, methods and preliminary results of this cohort study. 354 children underwent clinical and laboratory monitoring for two years, with 15% losses to follow-up. The overall rate of new infections was approximately 10% in the first year of follow-up. Information on the force of serotype-specific dengue infection and the evaluation of transferred maternal antibodies can contribute to understanding dengue etiopathogenesis.
publishDate 2016
dc.date.none.fl_str_mv 2016-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2016000100601
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2016000100601
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0102-311X00095815
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
publisher.none.fl_str_mv Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
dc.source.none.fl_str_mv Cadernos de Saúde Pública v.32 n.1 2016
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br
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