Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Cadernos de Saúde Pública |
| Texto Completo: | https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6080 |
Resumo: | Abstract Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Pernambuco State, Brazil, to determine the incidence of serotype-specific dengue infection and the kinetics of transferred maternal anti-dengue antibodies in the first years of life. This article describes the design, methods and preliminary results of this cohort study. 354 children underwent clinical and laboratory monitoring for two years, with 15% losses to follow-up. The overall rate of new infections was approximately 10% in the first year of follow-up. Information on the force of serotype-specific dengue infection and the evaluation of transferred maternal antibodies can contribute to understanding dengue etiopathogenesis. |
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Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary resultsPassive ImmunizationDengueCohort StudiesAbstract Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Pernambuco State, Brazil, to determine the incidence of serotype-specific dengue infection and the kinetics of transferred maternal anti-dengue antibodies in the first years of life. This article describes the design, methods and preliminary results of this cohort study. 354 children underwent clinical and laboratory monitoring for two years, with 15% losses to follow-up. The overall rate of new infections was approximately 10% in the first year of follow-up. Information on the force of serotype-specific dengue infection and the evaluation of transferred maternal antibodies can contribute to understanding dengue etiopathogenesis.Resumen Los casos de dengue han aumentado en los grupos de edad más jóvenes en Brasil. Los anticuerpos antidengue maternos pueden ejercer un efecto protector en los primeros meses de vida, pero su decremento puede aumentar el riesgo de dengue grave. Una cohorte de nacimientos prospectiva se estableció en la ciudad de Recife, Pernambuco, Brasil, entre 2011-2012, para determinar la incidencia de infección serotipo-específica de dengue y la cinética de los anticuerpos antidengue materno-transferidos durante los primeros años de vida. Este artículo describe el diseño, los métodos y resultados preliminares de este estudio de cohorte. 354 niños fueron acompañados clínicamente y en laboratorio durante dos años, con un 15% de pérdidas en el seguimiento. La tasa global de nuevas infecciones fue de aproximadamente un 10% en la cohorte de niños durante el primer año de seguimiento. La información sobre la fuerza de infección serotipo-específica del dengue en los primeros años de vida, así como la evaluación de la cinética de los anticuerpos materno-transferidos, podrá contribuir a la comprensión de la etiopatogenia de la enfermedad.Resumo Casos de dengue têm aumentado em grupos etários mais jovens no Brasil. Anticorpos antidengue maternos podem exercer efeito protetor nos primeiros meses de vida, mas seu declínio pode aumentar o risco de dengue grave. Uma coorte de nascimento prospectiva foi estabelecida na cidade do Recife, Pernambuco, Brasil, entre 2011-2012, para determinar a incidência de infecção sorotipo-específica do dengue e cinética dos anticorpos antidengue materno-transferidos nos primeiros anos de vida. Este artigo descreve o desenho, os métodos e resultados preliminares deste estudo de coorte. Trezentas e cinquenta e quatro crianças foram acompanhadas clínico e laboratorialmente por dois anos, com 15% de perdas de seguimento. A taxa global de novas infecções foi de aproximadamente 10% na coorte de crianças no primeiro ano de seguimento. Informações sobre a força de infecção sorotipo-específica do dengue nos primeiros anos de vida, bem como a avaliação da cinética de anticorpos materno-transferidos poderão contribuir para a compreensão da etiopatogenia da doença.Reports in Public HealthCadernos de Saúde Pública2016-02-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6080Reports in Public Health; Vol. 32 No. 1 (2016): JanuaryCadernos de Saúde Pública; v. 32 n. 1 (2016): Janeiro1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6080/12820https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6080/12821Cynthia BragaMaria de Fátima Pessoa Militão de AlbuquerqueMarli Tenório CordeiroPriscila M. S. CastanhaAnita RameshNeal AlexanderMaria Júlia G. de MelloErnesto T. A. Marques JrCelina M. Turchi Martelliinfo:eu-repo/semantics/openAccess2024-03-06T15:29:05Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/6080Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:06:57.065119Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true |
| dc.title.none.fl_str_mv |
Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results |
| title |
Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results |
| spellingShingle |
Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results Cynthia Braga Passive Immunization Dengue Cohort Studies |
| title_short |
Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results |
| title_full |
Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results |
| title_fullStr |
Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results |
| title_full_unstemmed |
Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results |
| title_sort |
Prospective birth cohort in a hyperendemic dengue area in Northeast Brazil: methods and preliminary results |
| author |
Cynthia Braga |
| author_facet |
Cynthia Braga Maria de Fátima Pessoa Militão de Albuquerque Marli Tenório Cordeiro Priscila M. S. Castanha Anita Ramesh Neal Alexander Maria Júlia G. de Mello Ernesto T. A. Marques Jr Celina M. Turchi Martelli |
| author_role |
author |
| author2 |
Maria de Fátima Pessoa Militão de Albuquerque Marli Tenório Cordeiro Priscila M. S. Castanha Anita Ramesh Neal Alexander Maria Júlia G. de Mello Ernesto T. A. Marques Jr Celina M. Turchi Martelli |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cynthia Braga Maria de Fátima Pessoa Militão de Albuquerque Marli Tenório Cordeiro Priscila M. S. Castanha Anita Ramesh Neal Alexander Maria Júlia G. de Mello Ernesto T. A. Marques Jr Celina M. Turchi Martelli |
| dc.subject.por.fl_str_mv |
Passive Immunization Dengue Cohort Studies |
| topic |
Passive Immunization Dengue Cohort Studies |
| description |
Abstract Dengue cases have increased in younger age groups in Brazil. Maternal anti-dengue antibodies can have a protective effect in the first months of life, but their decline can increase the risk of severe dengue. A prospective birth cohort was established in 2011-2012 in the city of Recife, Pernambuco State, Brazil, to determine the incidence of serotype-specific dengue infection and the kinetics of transferred maternal anti-dengue antibodies in the first years of life. This article describes the design, methods and preliminary results of this cohort study. 354 children underwent clinical and laboratory monitoring for two years, with 15% losses to follow-up. The overall rate of new infections was approximately 10% in the first year of follow-up. Information on the force of serotype-specific dengue infection and the evaluation of transferred maternal antibodies can contribute to understanding dengue etiopathogenesis. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016-02-12 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6080 |
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https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6080 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6080/12820 https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6080/12821 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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text/html application/pdf |
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Reports in Public Health Cadernos de Saúde Pública |
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Reports in Public Health Cadernos de Saúde Pública |
| dc.source.none.fl_str_mv |
Reports in Public Health; Vol. 32 No. 1 (2016): January Cadernos de Saúde Pública; v. 32 n. 1 (2016): Janeiro 1678-4464 0102-311X reponame:Cadernos de Saúde Pública instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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