Rationale for the study of the human sex ratio in population studies of polluted environments

Detalhes bibliográficos
Autor(a) principal: Jarrell,John
Data de Publicação: 2002
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2002000200007
Resumo: The human secondary sex ratio remains a subject of substantial interest. The possibility has been raised that environmental chemical exposures have played a role in the changes associated with the sex ratio in a number of countries. The possibility that such an effect may be present is supported at least theoretically by the observation that clomiphene citrate, a drug used in the treatment of infertility with powerful estrogenic and anti-estrogenic properties, has profound effects on the sex ratio resulting in significantly fewer males at birth. Using a model of causality based on the clinical identification of adverse drug effect methodology one may improve the objectivity of the assessment of significant environmental exposures on this human reproductive outcome.
id FIOCRUZ-5_3d30c3bf45366f8aa4bb1f72a670bd22
oai_identifier_str oai:scielo:S0102-311X2002000200007
network_acronym_str FIOCRUZ-5
network_name_str Cadernos de Saúde Pública
repository_id_str
spelling Rationale for the study of the human sex ratio in population studies of polluted environmentsSex RatioReproductionInfertilityEndocrine DisruptorsThe human secondary sex ratio remains a subject of substantial interest. The possibility has been raised that environmental chemical exposures have played a role in the changes associated with the sex ratio in a number of countries. The possibility that such an effect may be present is supported at least theoretically by the observation that clomiphene citrate, a drug used in the treatment of infertility with powerful estrogenic and anti-estrogenic properties, has profound effects on the sex ratio resulting in significantly fewer males at birth. Using a model of causality based on the clinical identification of adverse drug effect methodology one may improve the objectivity of the assessment of significant environmental exposures on this human reproductive outcome.Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz2002-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2002000200007Cadernos de Saúde Pública v.18 n.2 2002reponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZ10.1590/S0102-311X2002000200007info:eu-repo/semantics/openAccessJarrell,Johneng2002-03-26T00:00:00Zoai:scielo:S0102-311X2002000200007Revistahttp://cadernos.ensp.fiocruz.br/csp/https://old.scielo.br/oai/scielo-oai.phpcadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2002-03-26T00:00Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Rationale for the study of the human sex ratio in population studies of polluted environments
title Rationale for the study of the human sex ratio in population studies of polluted environments
spellingShingle Rationale for the study of the human sex ratio in population studies of polluted environments
Jarrell,John
Sex Ratio
Reproduction
Infertility
Endocrine Disruptors
title_short Rationale for the study of the human sex ratio in population studies of polluted environments
title_full Rationale for the study of the human sex ratio in population studies of polluted environments
title_fullStr Rationale for the study of the human sex ratio in population studies of polluted environments
title_full_unstemmed Rationale for the study of the human sex ratio in population studies of polluted environments
title_sort Rationale for the study of the human sex ratio in population studies of polluted environments
author Jarrell,John
author_facet Jarrell,John
author_role author
dc.contributor.author.fl_str_mv Jarrell,John
dc.subject.por.fl_str_mv Sex Ratio
Reproduction
Infertility
Endocrine Disruptors
topic Sex Ratio
Reproduction
Infertility
Endocrine Disruptors
description The human secondary sex ratio remains a subject of substantial interest. The possibility has been raised that environmental chemical exposures have played a role in the changes associated with the sex ratio in a number of countries. The possibility that such an effect may be present is supported at least theoretically by the observation that clomiphene citrate, a drug used in the treatment of infertility with powerful estrogenic and anti-estrogenic properties, has profound effects on the sex ratio resulting in significantly fewer males at birth. Using a model of causality based on the clinical identification of adverse drug effect methodology one may improve the objectivity of the assessment of significant environmental exposures on this human reproductive outcome.
publishDate 2002
dc.date.none.fl_str_mv 2002-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2002000200007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2002000200007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-311X2002000200007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
publisher.none.fl_str_mv Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
dc.source.none.fl_str_mv Cadernos de Saúde Pública v.18 n.2 2002
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br
_version_ 1754115720835235840

Registros relacionados