Rationale for the study of the human sex ratio in population studies of polluted environments

Detalhes bibliográficos
Autor(a) principal: Jarrell, John
Data de Publicação: 2002
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690
Resumo: The human secondary sex ratio remains a subject of substantial interest. The possibility has been raised that environmental chemical exposures have played a role in the changes associated with the sex ratio in a number of countries. The possibility that such an effect may be present is supported at least theoretically by the observation that clomiphene citrate, a drug used in the treatment of infertility with powerful estrogenic and anti-estrogenic properties, has profound effects on the sex ratio resulting in significantly fewer males at birth. Using a model of causality based on the clinical identification of adverse drug effect methodology one may improve the objectivity of the assessment of significant environmental exposures on this human reproductive outcome.
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spelling Rationale for the study of the human sex ratio in population studies of polluted environmentsSex RatioReproductionInfertilityEndocrine DisruptorsThe human secondary sex ratio remains a subject of substantial interest. The possibility has been raised that environmental chemical exposures have played a role in the changes associated with the sex ratio in a number of countries. The possibility that such an effect may be present is supported at least theoretically by the observation that clomiphene citrate, a drug used in the treatment of infertility with powerful estrogenic and anti-estrogenic properties, has profound effects on the sex ratio resulting in significantly fewer males at birth. Using a model of causality based on the clinical identification of adverse drug effect methodology one may improve the objectivity of the assessment of significant environmental exposures on this human reproductive outcome.A razão secundária de masculinidade em seres humanos continua suscitando bastante interesse. Em diversos países foi levantada a hipótese do papel da exposição química ambiental nas alterações associadas à razão de masculinidade. Tal efeito é sugerido, pelo menos teoricamente, pela observação de que o citrato de clomifene, droga utilizada no tratamento da infertilidade, com potentes propriedades estrogênicas e anti-estrogênicas, tem efeitos profundos sobre a razão de masculinidade, resultando no nascimento de uma proporção significativamente menor de machos. Utilizando um modelo causal baseado na identificação clínica de uma metodologia de efeito farmacológico adverso, pode-se melhorar a objetividade da avaliação da exposição ambiental significativa sobre esse desfecho reprodutivo em seres humanos.Reports in Public HealthCadernos de Saúde Pública2002-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690Reports in Public Health; Vol. 18 No. 2 (2002): March/AprilCadernos de Saúde Pública; v. 18 n. 2 (2002): Março/Abril1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690/3368https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690/3369Jarrell, Johninfo:eu-repo/semantics/openAccess2024-03-06T15:26:34Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/1690Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:01:59.003190Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true
dc.title.none.fl_str_mv Rationale for the study of the human sex ratio in population studies of polluted environments
title Rationale for the study of the human sex ratio in population studies of polluted environments
spellingShingle Rationale for the study of the human sex ratio in population studies of polluted environments
Jarrell, John
Sex Ratio
Reproduction
Infertility
Endocrine Disruptors
title_short Rationale for the study of the human sex ratio in population studies of polluted environments
title_full Rationale for the study of the human sex ratio in population studies of polluted environments
title_fullStr Rationale for the study of the human sex ratio in population studies of polluted environments
title_full_unstemmed Rationale for the study of the human sex ratio in population studies of polluted environments
title_sort Rationale for the study of the human sex ratio in population studies of polluted environments
author Jarrell, John
author_facet Jarrell, John
author_role author
dc.contributor.author.fl_str_mv Jarrell, John
dc.subject.por.fl_str_mv Sex Ratio
Reproduction
Infertility
Endocrine Disruptors
topic Sex Ratio
Reproduction
Infertility
Endocrine Disruptors
description The human secondary sex ratio remains a subject of substantial interest. The possibility has been raised that environmental chemical exposures have played a role in the changes associated with the sex ratio in a number of countries. The possibility that such an effect may be present is supported at least theoretically by the observation that clomiphene citrate, a drug used in the treatment of infertility with powerful estrogenic and anti-estrogenic properties, has profound effects on the sex ratio resulting in significantly fewer males at birth. Using a model of causality based on the clinical identification of adverse drug effect methodology one may improve the objectivity of the assessment of significant environmental exposures on this human reproductive outcome.
publishDate 2002
dc.date.none.fl_str_mv 2002-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690
url https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690/3368
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1690/3369
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
application/pdf
dc.publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
dc.source.none.fl_str_mv Reports in Public Health; Vol. 18 No. 2 (2002): March/April
Cadernos de Saúde Pública; v. 18 n. 2 (2002): Março/Abril
1678-4464
0102-311X
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
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