On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1995 |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Cadernos de Saúde Pública |
| Texto Completo: | https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/728 |
Resumo: | The present communication analyses methodological problems related to evaluating the protection given by the antimeningococcal B vaccine to children under four years of age in a case-control study carried out in Sao Paulo, Brazil. Detection of a hospital selection bias, among other disturbing features of the study, suggests that the efficacy of the vaccine was underestimated. Altogether, data presented support a wider use of the Cuban-produced vaccine to reduce morbidity and mortality from serogroup B meningococcal disease. |
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On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfallsMeningococcal DiseaseCase-selection BiasAnti-meningococcal B VaccineVaccine EfficacyNeisseria meningitidisThe present communication analyses methodological problems related to evaluating the protection given by the antimeningococcal B vaccine to children under four years of age in a case-control study carried out in Sao Paulo, Brazil. Detection of a hospital selection bias, among other disturbing features of the study, suggests that the efficacy of the vaccine was underestimated. Altogether, data presented support a wider use of the Cuban-produced vaccine to reduce morbidity and mortality from serogroup B meningococcal disease.A presente comunicação analisa problemas metodológicos relacionados à avaliação da proteção conferida pela vacina anti-meningocócica B em crianças menores de quatro anos no Brasil em artigo utilizado como referência sobre o assunto. A identificação de sério viés na seleção dos casos, não só sugere que a eficácia da vacina é superior à encontrada, tornando seu uso a melhor arma disponível para reduzir a morbimortalidade da doença meningocócica, como coloca novos parâmetros para futuros estudos epidemiológicos sobre essa dramática doença.Reports in Public HealthCadernos de Saúde Pública1995-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/728Reports in Public Health; Vol. 11 No. 2 (1995): April/JuneCadernos de Saúde Pública; v. 11 n. 2 (1995): Abril/Junho1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/728/1472https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/728/1473Costa, Eduardo de A.info:eu-repo/semantics/openAccess2024-03-06T15:26:02Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/728Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:00:55.123160Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true |
| dc.title.none.fl_str_mv |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
| title |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
| spellingShingle |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls Costa, Eduardo de A. Meningococcal Disease Case-selection Bias Anti-meningococcal B Vaccine Vaccine Efficacy Neisseria meningitidis |
| title_short |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
| title_full |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
| title_fullStr |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
| title_full_unstemmed |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
| title_sort |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
| author |
Costa, Eduardo de A. |
| author_facet |
Costa, Eduardo de A. |
| author_role |
author |
| dc.contributor.author.fl_str_mv |
Costa, Eduardo de A. |
| dc.subject.por.fl_str_mv |
Meningococcal Disease Case-selection Bias Anti-meningococcal B Vaccine Vaccine Efficacy Neisseria meningitidis |
| topic |
Meningococcal Disease Case-selection Bias Anti-meningococcal B Vaccine Vaccine Efficacy Neisseria meningitidis |
| description |
The present communication analyses methodological problems related to evaluating the protection given by the antimeningococcal B vaccine to children under four years of age in a case-control study carried out in Sao Paulo, Brazil. Detection of a hospital selection bias, among other disturbing features of the study, suggests that the efficacy of the vaccine was underestimated. Altogether, data presented support a wider use of the Cuban-produced vaccine to reduce morbidity and mortality from serogroup B meningococcal disease. |
| publishDate |
1995 |
| dc.date.none.fl_str_mv |
1995-06-01 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/728 |
| url |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/728 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/728/1472 https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/728/1473 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
text/html application/pdf |
| dc.publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
| publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
| dc.source.none.fl_str_mv |
Reports in Public Health; Vol. 11 No. 2 (1995): April/June Cadernos de Saúde Pública; v. 11 n. 2 (1995): Abril/Junho 1678-4464 0102-311X reponame:Cadernos de Saúde Pública instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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FIOCRUZ |
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FIOCRUZ |
| reponame_str |
Cadernos de Saúde Pública |
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Cadernos de Saúde Pública |
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Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ) |
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cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br |
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