On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Cadernos de Saúde Pública |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X1995000200018 |
Resumo: | The present communication analyses methodological problems related to evaluating the protection given by the antimeningococcal B vaccine to children under four years of age in a case-control study carried out in Sao Paulo, Brazil. Detection of a hospital selection bias, among other disturbing features of the study, suggests that the efficacy of the vaccine was underestimated. Altogether, data presented support a wider use of the Cuban-produced vaccine to reduce morbidity and mortality from serogroup B meningococcal disease. |
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On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfallsMeningococcal DiseaseCase-selection BiasAnti-meningococcal B VaccineVaccine EfficacyNeisseria meningitidisThe present communication analyses methodological problems related to evaluating the protection given by the antimeningococcal B vaccine to children under four years of age in a case-control study carried out in Sao Paulo, Brazil. Detection of a hospital selection bias, among other disturbing features of the study, suggests that the efficacy of the vaccine was underestimated. Altogether, data presented support a wider use of the Cuban-produced vaccine to reduce morbidity and mortality from serogroup B meningococcal disease.Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz1995-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X1995000200018Cadernos de Saúde Pública v.11 n.2 1995reponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZ10.1590/S0102-311X1995000200018info:eu-repo/semantics/openAccessCosta,Eduardo de A.eng2003-09-29T00:00:00Zoai:scielo:S0102-311X1995000200018Revistahttp://cadernos.ensp.fiocruz.br/csp/https://old.scielo.br/oai/scielo-oai.phpcadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2003-09-29T00:00Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.none.fl_str_mv |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
title |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
spellingShingle |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls Costa,Eduardo de A. Meningococcal Disease Case-selection Bias Anti-meningococcal B Vaccine Vaccine Efficacy Neisseria meningitidis |
title_short |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
title_full |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
title_fullStr |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
title_full_unstemmed |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
title_sort |
On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
author |
Costa,Eduardo de A. |
author_facet |
Costa,Eduardo de A. |
author_role |
author |
dc.contributor.author.fl_str_mv |
Costa,Eduardo de A. |
dc.subject.por.fl_str_mv |
Meningococcal Disease Case-selection Bias Anti-meningococcal B Vaccine Vaccine Efficacy Neisseria meningitidis |
topic |
Meningococcal Disease Case-selection Bias Anti-meningococcal B Vaccine Vaccine Efficacy Neisseria meningitidis |
description |
The present communication analyses methodological problems related to evaluating the protection given by the antimeningococcal B vaccine to children under four years of age in a case-control study carried out in Sao Paulo, Brazil. Detection of a hospital selection bias, among other disturbing features of the study, suggests that the efficacy of the vaccine was underestimated. Altogether, data presented support a wider use of the Cuban-produced vaccine to reduce morbidity and mortality from serogroup B meningococcal disease. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X1995000200018 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X1995000200018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-311X1995000200018 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz |
publisher.none.fl_str_mv |
Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz |
dc.source.none.fl_str_mv |
Cadernos de Saúde Pública v.11 n.2 1995 reponame:Cadernos de Saúde Pública instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Cadernos de Saúde Pública |
collection |
Cadernos de Saúde Pública |
repository.name.fl_str_mv |
Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br |
_version_ |
1754115717502861312 |