Seroprevalence and factors associated with Leptospira infection in an urban district of Cali, Colombia

Detalhes bibliográficos
Autor(a) principal: Kevin Escandón-Vargas
Data de Publicação: 2017
Outros Autores: Lyda Osorio, Miryam Astudillo-Hernández
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6442
Resumo: Few studies have addressed Leptospira seroprevalence and risk factors in urban populations in Colombia. This study aimed to determine seroprevalence and factors associated with Leptospira infection in inhabitants of an urban district of Cali, Colombia. We collected sociodemographic and environmental data, as well as blood samples, from 353 subjects selected through a multistage cluster sampling design. We performed microagglutination test for the eight main Leptospira serogroups circulating in the region, considering a cut-off titer of ≥ 1:100. Most participants were female (226, 64.8%), with mean age 41.4 years, and 89 (32.6%) lived in low-low socioeconomic stratum (SES-1). Overall seroprevalence was 12.2% (95%CI: 10.3%-14.4%). Factors associated with Leptospira infection were SES 1, older age, single marital status, ethnic groups (Afro-Colombian and white/mestizo), school students, absence of toilet, barefoot walking, travel outside Cali in the previous month, and absence of skin and mucous-membrane lesions in the previous month. Our study suggests domestic and peridomiciliary transmission of Leptospira likely related to activities of daily living and inadequate environmental conditions. SES-1 is a major factor associated with Leptospira infection (adjusted OR = 4.08; 95%CI: 2.54-6.53; p < 0.001), suggesting that social and environmental conditions are key elements for endemicity of Leptospira infection in the study area. Epidemiological surveillance, improvement of environmental and sanitary conditions in various SES-1 areas, and community educational campaigns are recommended.
id FIOCRUZ-5_77ef843627f55076ca110565bd9bd440
oai_identifier_str oai:ojs.teste-cadernos.ensp.fiocruz.br:article/6442
network_acronym_str FIOCRUZ-5
network_name_str Cadernos de Saúde Pública
repository_id_str
spelling Seroprevalence and factors associated with Leptospira infection in an urban district of Cali, ColombiaLeptospirosisLeptospiraCommunicable DiseasesFew studies have addressed Leptospira seroprevalence and risk factors in urban populations in Colombia. This study aimed to determine seroprevalence and factors associated with Leptospira infection in inhabitants of an urban district of Cali, Colombia. We collected sociodemographic and environmental data, as well as blood samples, from 353 subjects selected through a multistage cluster sampling design. We performed microagglutination test for the eight main Leptospira serogroups circulating in the region, considering a cut-off titer of ≥ 1:100. Most participants were female (226, 64.8%), with mean age 41.4 years, and 89 (32.6%) lived in low-low socioeconomic stratum (SES-1). Overall seroprevalence was 12.2% (95%CI: 10.3%-14.4%). Factors associated with Leptospira infection were SES 1, older age, single marital status, ethnic groups (Afro-Colombian and white/mestizo), school students, absence of toilet, barefoot walking, travel outside Cali in the previous month, and absence of skin and mucous-membrane lesions in the previous month. Our study suggests domestic and peridomiciliary transmission of Leptospira likely related to activities of daily living and inadequate environmental conditions. SES-1 is a major factor associated with Leptospira infection (adjusted OR = 4.08; 95%CI: 2.54-6.53; p < 0.001), suggesting that social and environmental conditions are key elements for endemicity of Leptospira infection in the study area. Epidemiological surveillance, improvement of environmental and sanitary conditions in various SES-1 areas, and community educational campaigns are recommended.Pocos estudios se han centrado en la seroprevalencia por Leptospira y sus factores de riesgo en poblaciones urbanas de Colombia. Este estudio tuvo como meta determinar la seroprevalencia y los factores asociados a la infección por Leptospira en una población residente de un distrito urbano de Cali, Colombia. Recogimos datos sociodemográficos y ambientales, así como muestras de sangre, de 353 sujetos seleccionados a través de un diseño de muestreo por conglomerados en etapas múltiples. Se realizó un test de microaglutinación para los ocho serogrupos principales de Leptospira circulando en la región, considerando una zona corte de ≥ 1:100. La mayoría de los participantes fueron mujeres (226, un 64,8%), con un promedio de edad de 41,4 años, con 89 (32,6%) que vivían en condiciones socioeconómicas bajas o muy bajas (SES-1). La seroprevalencia global fue de un 12,2% (IC95%: 10,3%-14,4%). Los factores asociados con la infección por Leptospira fueron SES-1, edad más avanzada, estado civil soltera, grupo étnico (afrocolombiano y blanco/mestizo), estudiantes escolares, ausencia de baño, caminar descalzo, viajar fuera de Cali durante el mes previo al estudio, y ausencia de lesiones en la piel y membranas mucosas durante el mes previo al mismo. Nuestro estudio sugiere que la trasmisión doméstica y peridomiciliaria de la Leptospira está vinculada a actividades de la vida diaria y a condiciones ambientales inadecuadas. SES-1 es un factor importante, asociado a la infección por Leptospira (OR ajustada = 4,08; IC95%: 2,54-6,53; p < 0,001), sugiriendo que las condiciones sociales y ambientales son elementos clave para la endemicidad de la infección por Leptospira en el área de estudio. Se recomienda vigilancia epidemiológica, mejora de las condiciones ambientales y sanitarias en varias áreas SES-1, así como campañas educacionales dirigidas a la comunidad.Poucos estudos trataram da soroprevalência para Leptospira e fatores de risco em populações urbanas da Colômbia. Este estudo teve como objetivo determinar a soroprevalência e fatores associados com a infecção por Leptospira nos habitantes de um distrito urbano de Cali, Colômbia. Os autores coletaram dados sociodemográficos e ambientais, além de amostras de sangue, de 353 indivíduos selecionados através de uma amostragem de aglomerados em múltiplas fases. Foi realizado o teste de microaglutinação para os oitos principais grupos sorológicos da Leptospira circulantes na região, considerando um título de ≥ 1:100. A maioria dos participantes era do sexo feminino (226, 64,8%), com média de idade de 41,4 anos; 89 (32,6%) pertenciam ao estrato socioeconômico mais baixo (SES-1). A soroprevalência global era 12,2% (IC95%: 10,3%-14,4%). Os fatores associados à infecção por Leptospira eram SES-1, idade, estado civil solteiro, grupo étnico (afro-colombiano e branco/mestiço), estudantes, ausência de privada no domicílio, andar descalço, viagem fora de Cali no mês anterior e ausência de lesões mucocutâneas no mês anterior. O estudo sugere a transmissão domiciliar e peridomiciliar da Leptospira, provavelmente associada a atividades cotidianas e condições ambientais adversas. SES-1 é um fator importante associado à infecção com Leptospira (OR ajustado = 4,08; IC95%: 2,54-6,53; p < 0,001), indicando que as condições sociais e ambientais são elementos importantes na endemicidade da leptospirose na área do estudo. Recomendamos a vigilância epidemiológica, melhora das condições ambientais e sanitárias em diversas áreas SES-1 e campanhas educativas comunitárias.Reports in Public HealthCadernos de Saúde Pública2017-06-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6442Reports in Public Health; Vol. 33 No. 5 (2017): MayCadernos de Saúde Pública; v. 33 n. 5 (2017): Maio1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6442/13760https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6442/13761Kevin Escandón-VargasLyda OsorioMiryam Astudillo-Hernándezinfo:eu-repo/semantics/openAccess2024-03-06T15:29:19Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/6442Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:07:22.893402Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true
dc.title.none.fl_str_mv Seroprevalence and factors associated with Leptospira infection in an urban district of Cali, Colombia
title Seroprevalence and factors associated with Leptospira infection in an urban district of Cali, Colombia
spellingShingle Seroprevalence and factors associated with Leptospira infection in an urban district of Cali, Colombia
Kevin Escandón-Vargas
Leptospirosis
Leptospira
Communicable Diseases
title_short Seroprevalence and factors associated with Leptospira infection in an urban district of Cali, Colombia
title_full Seroprevalence and factors associated with Leptospira infection in an urban district of Cali, Colombia
title_fullStr Seroprevalence and factors associated with Leptospira infection in an urban district of Cali, Colombia
title_full_unstemmed Seroprevalence and factors associated with Leptospira infection in an urban district of Cali, Colombia
title_sort Seroprevalence and factors associated with Leptospira infection in an urban district of Cali, Colombia
author Kevin Escandón-Vargas
author_facet Kevin Escandón-Vargas
Lyda Osorio
Miryam Astudillo-Hernández
author_role author
author2 Lyda Osorio
Miryam Astudillo-Hernández
author2_role author
author
dc.contributor.author.fl_str_mv Kevin Escandón-Vargas
Lyda Osorio
Miryam Astudillo-Hernández
dc.subject.por.fl_str_mv Leptospirosis
Leptospira
Communicable Diseases
topic Leptospirosis
Leptospira
Communicable Diseases
description Few studies have addressed Leptospira seroprevalence and risk factors in urban populations in Colombia. This study aimed to determine seroprevalence and factors associated with Leptospira infection in inhabitants of an urban district of Cali, Colombia. We collected sociodemographic and environmental data, as well as blood samples, from 353 subjects selected through a multistage cluster sampling design. We performed microagglutination test for the eight main Leptospira serogroups circulating in the region, considering a cut-off titer of ≥ 1:100. Most participants were female (226, 64.8%), with mean age 41.4 years, and 89 (32.6%) lived in low-low socioeconomic stratum (SES-1). Overall seroprevalence was 12.2% (95%CI: 10.3%-14.4%). Factors associated with Leptospira infection were SES 1, older age, single marital status, ethnic groups (Afro-Colombian and white/mestizo), school students, absence of toilet, barefoot walking, travel outside Cali in the previous month, and absence of skin and mucous-membrane lesions in the previous month. Our study suggests domestic and peridomiciliary transmission of Leptospira likely related to activities of daily living and inadequate environmental conditions. SES-1 is a major factor associated with Leptospira infection (adjusted OR = 4.08; 95%CI: 2.54-6.53; p < 0.001), suggesting that social and environmental conditions are key elements for endemicity of Leptospira infection in the study area. Epidemiological surveillance, improvement of environmental and sanitary conditions in various SES-1 areas, and community educational campaigns are recommended.
publishDate 2017
dc.date.none.fl_str_mv 2017-06-12
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6442
url https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6442
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6442/13760
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/6442/13761
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
application/pdf
dc.publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
dc.source.none.fl_str_mv Reports in Public Health; Vol. 33 No. 5 (2017): May
Cadernos de Saúde Pública; v. 33 n. 5 (2017): Maio
1678-4464
0102-311X
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br
_version_ 1816705374949998592