Chemical exposure during pregnancy and oral clefts in newborns

Detalhes bibliográficos
Autor(a) principal: Leite, Isabel Cristina Gonçalves
Data de Publicação: 2002
Outros Autores: Paumgartten, Francisco José Roma, Koifman, Sérgio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1831
Resumo: This article presents a literature review on the risk factors for oral clefts (lip and/or palate), emphasizing discussion of maternal exposure to endocrine disruptors. Several studies have identified the risk of cigarette smoking and alcohol consumption, use of anticonvulsivant drugs, and exposure to organic solvents. A protective effect has been shown for supplementation with folic acid. As with other chemicals, the risk associated with exposure to sex hormones is still obscure, although some authors describe a moderate risk level. New studies addressing this hypothesis need to be conducted, while the population exposed to these endocrine disrupters is increasing.
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spelling Chemical exposure during pregnancy and oral clefts in newbornsCleft PalateCleft LipHormonesRisk FactorsThis article presents a literature review on the risk factors for oral clefts (lip and/or palate), emphasizing discussion of maternal exposure to endocrine disruptors. Several studies have identified the risk of cigarette smoking and alcohol consumption, use of anticonvulsivant drugs, and exposure to organic solvents. A protective effect has been shown for supplementation with folic acid. As with other chemicals, the risk associated with exposure to sex hormones is still obscure, although some authors describe a moderate risk level. New studies addressing this hypothesis need to be conducted, while the population exposed to these endocrine disrupters is increasing.O presente artigo apresenta uma revisão bibliográfica sobre os fatores de risco para a ocorrência de fendas lábio-palatinas descritos na literatura, destacando a discussão sobre a exposição hormonal materna durante a gravidez. Os trabalhos analisados apontam como fatores de risco o tabagismo e a ingestão de álcool, uso de anticonvulsivantes e exposições a solventes orgânicos, e como fator de proteção, a administração de ácido fólico. O risco associado à exposição hormonal, bem como a outros fatores, ainda é obscuro, embora alguns autores descrevam moderadas magnitudes de risco. Novos estudos, especificamente elaborados para testar esta hipótese, devem ser realizados à medida em que aumenta a população exposta a drogas de ação endócrina.Reports in Public HealthCadernos de Saúde Pública2002-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1831Reports in Public Health; Vol. 18 No. 1 (2002): January/FebruaryCadernos de Saúde Pública; v. 18 n. 1 (2002): Janeiro/Fevereiro1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1831/3650https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1831/3651Leite, Isabel Cristina GonçalvesPaumgartten, Francisco José RomaKoifman, Sérgioinfo:eu-repo/semantics/openAccess2024-03-06T15:26:40Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/1831Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:02:10.804590Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true
dc.title.none.fl_str_mv Chemical exposure during pregnancy and oral clefts in newborns
title Chemical exposure during pregnancy and oral clefts in newborns
spellingShingle Chemical exposure during pregnancy and oral clefts in newborns
Leite, Isabel Cristina Gonçalves
Cleft Palate
Cleft Lip
Hormones
Risk Factors
title_short Chemical exposure during pregnancy and oral clefts in newborns
title_full Chemical exposure during pregnancy and oral clefts in newborns
title_fullStr Chemical exposure during pregnancy and oral clefts in newborns
title_full_unstemmed Chemical exposure during pregnancy and oral clefts in newborns
title_sort Chemical exposure during pregnancy and oral clefts in newborns
author Leite, Isabel Cristina Gonçalves
author_facet Leite, Isabel Cristina Gonçalves
Paumgartten, Francisco José Roma
Koifman, Sérgio
author_role author
author2 Paumgartten, Francisco José Roma
Koifman, Sérgio
author2_role author
author
dc.contributor.author.fl_str_mv Leite, Isabel Cristina Gonçalves
Paumgartten, Francisco José Roma
Koifman, Sérgio
dc.subject.por.fl_str_mv Cleft Palate
Cleft Lip
Hormones
Risk Factors
topic Cleft Palate
Cleft Lip
Hormones
Risk Factors
description This article presents a literature review on the risk factors for oral clefts (lip and/or palate), emphasizing discussion of maternal exposure to endocrine disruptors. Several studies have identified the risk of cigarette smoking and alcohol consumption, use of anticonvulsivant drugs, and exposure to organic solvents. A protective effect has been shown for supplementation with folic acid. As with other chemicals, the risk associated with exposure to sex hormones is still obscure, although some authors describe a moderate risk level. New studies addressing this hypothesis need to be conducted, while the population exposed to these endocrine disrupters is increasing.
publishDate 2002
dc.date.none.fl_str_mv 2002-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1831
url https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1831
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1831/3650
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/1831/3651
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
application/pdf
dc.publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
dc.source.none.fl_str_mv Reports in Public Health; Vol. 18 No. 1 (2002): January/February
Cadernos de Saúde Pública; v. 18 n. 1 (2002): Janeiro/Fevereiro
1678-4464
0102-311X
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br
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