Tuberculosis in childhood and adolescence: prevalence and factors associated with treatment abandonment

Detalhes bibliográficos
Autor(a) principal: Pereira da Soledade, Mariana
Data de Publicação: 2024
Outros Autores: Miyuki Yamauti, Sueli, Simões Aguiar, Andressa, Sucupira, Carolina, Teresinha Lonardoni Crozatti, Márcia
Tipo de documento: Artigo
Idioma: por
Título da fonte: Cadernos de Saúde Pública
Texto Completo: https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/8697
Resumo: Tuberculosis (TB) is an infectious disease that remains a serious public health problem worldwide. In the pediatric population, the knowledge about the factors that lead to the abandonment of TB treatment is limited, especially in regions with a high prevalence of the disease. This study aimed to identify the prevalence and risk factors associated with TB treatment abandonment in children and adolescents. A cross-sectional study was carried out using data obtained from TB notifications from the São Paulo State Tuberculosis Patient Control System, Brazil, for individuals aged between 0 and 18 years, from January 2009 to December 2019. The crude and adjusted prevalence ratios were estimated with a 95% confidence interval, using the Poisson regression model to identify associations between the outcome of treatment abandonment and the sociodemographic, clinical-epidemiological, diagnostic and therapeutic factors of TB cases with complete information. Of the 12,256 cases analyzed, 941 individuals abandoned treatment. The highest prevalence rate of treatment abandonment occurs among Black or brown adolescents, those over 11 years of age and those deprived of their liberty. Other characteristics associated with treatment abandonment include: being a person living with HIV/AIDS, having a history of previous TB treatment, using illicit substances and using a self-administered TB treatment regimen. Knowing the profile of the patient most likely to abandon TB treatment makes it possible to devise more effective strategies focused on adherence to drug treatment.
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spelling Tuberculosis in childhood and adolescence: prevalence and factors associated with treatment abandonmentTuberculosis en la infancia y la adolescencia: prevalencia y factores asociados al abandono del tratamientoTuberculose na infância e adolescência: prevalência e fatores associados ao abandono do tratamentoTuberculose; Pediatria; Pacientes Desistentes do Tratamento; Fatores de RiscoTuberculosis; Pediatría; Pacientes Desistentes del Tratamiento; Factores de RiesgoTuberculosis; Pediatrics; Patient Dropouts; Risk FactorsTuberculosis (TB) is an infectious disease that remains a serious public health problem worldwide. In the pediatric population, the knowledge about the factors that lead to the abandonment of TB treatment is limited, especially in regions with a high prevalence of the disease. This study aimed to identify the prevalence and risk factors associated with TB treatment abandonment in children and adolescents. A cross-sectional study was carried out using data obtained from TB notifications from the São Paulo State Tuberculosis Patient Control System, Brazil, for individuals aged between 0 and 18 years, from January 2009 to December 2019. The crude and adjusted prevalence ratios were estimated with a 95% confidence interval, using the Poisson regression model to identify associations between the outcome of treatment abandonment and the sociodemographic, clinical-epidemiological, diagnostic and therapeutic factors of TB cases with complete information. Of the 12,256 cases analyzed, 941 individuals abandoned treatment. The highest prevalence rate of treatment abandonment occurs among Black or brown adolescents, those over 11 years of age and those deprived of their liberty. Other characteristics associated with treatment abandonment include: being a person living with HIV/AIDS, having a history of previous TB treatment, using illicit substances and using a self-administered TB treatment regimen. Knowing the profile of the patient most likely to abandon TB treatment makes it possible to devise more effective strategies focused on adherence to drug treatment.La tuberculosis (TB) es una enfermedad infectocontagiosa que sigue siendo un grave problema de salud pública mundial. Se sabe poco sobre los factores que conducen al abandono del tratamiento de la TB en la población pediátrica, especialmente en regiones con alta prevalencia de la enfermedad. Por lo tanto, este estudio tuvo como objetivo identificar la prevalencia y los factores de riesgo asociados con el abandono del tratamiento de la TB en niños y adolescentes. Se trató de un estudio transversal realizado a partir de los datos de notificaciones de TB del Sistema de Control de Pacientes con Tuberculosis del Estado de São Paulo, Brasil, recopilados de individuos con edades comprendidas entre 0 y 18 años, en el período de enero de 2009 a diciembre de 2019. La relación de prevalencia bruta y ajustada se estimó con un intervalo de 95% de confianza; y se utilizó el modelo de regresión de Poisson para identificar las asociaciones entre el resultado del abandono del tratamiento y los factores sociodemográficos, clínico-epidemiológicos, diagnósticos y terapéuticos de los casos de TB que contienen información completa. De los 12.256 casos analizados, 941 individuos habían abandonado el tratamiento. La mayor tasa de prevalencia de abandono del tratamiento se dio entre adolescentes negros o pardos, mayores de 11 años y los privados de libertad. Otras características asociadas con el abandono del tratamiento fueron personas que viven con VIH/sida, tener antecedentes de tratamiento previo de TB, usar sustancias ilícitas y utilizar el régimen de tratamiento de TB autoadministrado. Se concluyó que conocer el perfil de los pacientes con mayor tendencia a abandonar el tratamiento de la TB nos permite desarrollar estrategias efectivas enfocadas en una adherencia al tratamiento farmacológico.A tuberculose (TB) é uma doença infectocontagiosa que ainda representa um grave problema de saúde pública no mundo. Na população pediátrica, os fatores que levam ao abandono do tratamento da TB, especialmente em regiões de elevada prevalência da doença, são pouco conhecidos. Portanto, este estudo objetivou identificar a prevalência e os fatores de risco associados ao abandono do tratamento da TB em crianças e adolescentes. Foi realizado um estudo transversal com dados obtidos das notificações de TB provenientes do Sistema de Controle de Pacientes com Tuberculose do Estado de São Paulo, Brasil, em indivíduos com idade entre 0 e 18 anos, no período de janeiro de 2009 a dezembro de 2019. Estimou-se a razão de prevalência bruta e ajustada com intervalo de 95% de confiança, utilizando-se o modelo de regressão de Poisson para identificar associações entre o desfecho abandono do tratamento com os fatores sociodemográficos, clínico-epidemiológicos, diagnósticos e terapêuticos dos casos de TB, contendo informações completas. Dos 12.256 casos analisados, 941 indivíduos abandonaram o tratamento. A maior taxa de prevalência de abandono do tratamento ocorre entre os adolescentes pretos ou pardos, acima de 11 anos e privados de liberdade. Outras características associadas ao abandono do tratamento incluem: serem pessoas vivendo com HIV/aids, ter histórico de tratamento anterior para TB, fazer uso de substâncias ilícitas e utilizar o regime de tratamento de TB autoadministrado. Concluiu-se que conhecer o perfil do paciente com maiores chances para abandonar o tratamento da TB permite elaborar estratégias focadas na adesão ao tratamento medicamentoso mais efetivas.Reports in Public HealthCadernos de Saúde Pública2024-09-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/xmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/8697Reports in Public Health; Vol. 40 No. 9 (2024): SeptemberCadernos de Saúde Pública; v. 40 n. 9 (2024): Setembro1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/8697/19691https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/8697/19692Copyright (c) 2024 Cadernos de Saúde Públicainfo:eu-repo/semantics/openAccessPereira da Soledade, MarianaMiyuki Yamauti, SueliSimões Aguiar, AndressaSucupira, CarolinaTeresinha Lonardoni Crozatti, Márcia2024-09-11T15:16:01Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/8697Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/cspPUBhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-09-11T15:16:01Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Tuberculosis in childhood and adolescence: prevalence and factors associated with treatment abandonment
Tuberculosis en la infancia y la adolescencia: prevalencia y factores asociados al abandono del tratamiento
Tuberculose na infância e adolescência: prevalência e fatores associados ao abandono do tratamento
title Tuberculosis in childhood and adolescence: prevalence and factors associated with treatment abandonment
spellingShingle Tuberculosis in childhood and adolescence: prevalence and factors associated with treatment abandonment
Pereira da Soledade, Mariana
Tuberculose; Pediatria; Pacientes Desistentes do Tratamento; Fatores de Risco
Tuberculosis; Pediatría; Pacientes Desistentes del Tratamiento; Factores de Riesgo
Tuberculosis; Pediatrics; Patient Dropouts; Risk Factors
title_short Tuberculosis in childhood and adolescence: prevalence and factors associated with treatment abandonment
title_full Tuberculosis in childhood and adolescence: prevalence and factors associated with treatment abandonment
title_fullStr Tuberculosis in childhood and adolescence: prevalence and factors associated with treatment abandonment
title_full_unstemmed Tuberculosis in childhood and adolescence: prevalence and factors associated with treatment abandonment
title_sort Tuberculosis in childhood and adolescence: prevalence and factors associated with treatment abandonment
author Pereira da Soledade, Mariana
author_facet Pereira da Soledade, Mariana
Miyuki Yamauti, Sueli
Simões Aguiar, Andressa
Sucupira, Carolina
Teresinha Lonardoni Crozatti, Márcia
author_role author
author2 Miyuki Yamauti, Sueli
Simões Aguiar, Andressa
Sucupira, Carolina
Teresinha Lonardoni Crozatti, Márcia
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pereira da Soledade, Mariana
Miyuki Yamauti, Sueli
Simões Aguiar, Andressa
Sucupira, Carolina
Teresinha Lonardoni Crozatti, Márcia
dc.subject.por.fl_str_mv Tuberculose; Pediatria; Pacientes Desistentes do Tratamento; Fatores de Risco
Tuberculosis; Pediatría; Pacientes Desistentes del Tratamiento; Factores de Riesgo
Tuberculosis; Pediatrics; Patient Dropouts; Risk Factors
topic Tuberculose; Pediatria; Pacientes Desistentes do Tratamento; Fatores de Risco
Tuberculosis; Pediatría; Pacientes Desistentes del Tratamiento; Factores de Riesgo
Tuberculosis; Pediatrics; Patient Dropouts; Risk Factors
description Tuberculosis (TB) is an infectious disease that remains a serious public health problem worldwide. In the pediatric population, the knowledge about the factors that lead to the abandonment of TB treatment is limited, especially in regions with a high prevalence of the disease. This study aimed to identify the prevalence and risk factors associated with TB treatment abandonment in children and adolescents. A cross-sectional study was carried out using data obtained from TB notifications from the São Paulo State Tuberculosis Patient Control System, Brazil, for individuals aged between 0 and 18 years, from January 2009 to December 2019. The crude and adjusted prevalence ratios were estimated with a 95% confidence interval, using the Poisson regression model to identify associations between the outcome of treatment abandonment and the sociodemographic, clinical-epidemiological, diagnostic and therapeutic factors of TB cases with complete information. Of the 12,256 cases analyzed, 941 individuals abandoned treatment. The highest prevalence rate of treatment abandonment occurs among Black or brown adolescents, those over 11 years of age and those deprived of their liberty. Other characteristics associated with treatment abandonment include: being a person living with HIV/AIDS, having a history of previous TB treatment, using illicit substances and using a self-administered TB treatment regimen. Knowing the profile of the patient most likely to abandon TB treatment makes it possible to devise more effective strategies focused on adherence to drug treatment.
publishDate 2024
dc.date.none.fl_str_mv 2024-09-11
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dc.identifier.uri.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/8697
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dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/8697/19691
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/8697/19692
dc.rights.driver.fl_str_mv Copyright (c) 2024 Cadernos de Saúde Pública
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2024 Cadernos de Saúde Pública
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/xml
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dc.publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
dc.source.none.fl_str_mv Reports in Public Health; Vol. 40 No. 9 (2024): September
Cadernos de Saúde Pública; v. 40 n. 9 (2024): Setembro
1678-4464
0102-311X
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
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