Use of nanoparticles in cell tracing in advanced therapies: possibilities and challenges for clinical application

Detalhes bibliográficos
Autor(a) principal: Jasmin, .
Data de Publicação: 2018
Outros Autores: Borojevic, Radovan
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Vigilância Sanitária em Debate
Texto Completo: https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/1067
Resumo: Introduction: Regulation and introduction of new advanced cellular technologies in clinics requires better knowledge on the used cells. One of the major challenges is the difficulty to accurately determine the mechanisms of cell activities when submitted to advanced therapies. Objective: Understand, using the cell tracking methods, the tissue distribution and the molecular response of cells exposed to advanced therapies. Methods: This work was done as an integrated review of data collected in international data-bases and of legislations concerning the clinical use of nanoparticles. Results: Nanotechnology is a very useful tool for cell tracking in vivo, and several nanoparticles have been already approved for clinical use; they can be incorporated into cells and visualized by magnetic resonance imaging. Conclusions: The perspectives on the use of nanomedicines for cellular tracking in medical clinic are promising, requiring elaboration and approval of laws, guides and norms to orient the industrial sectors, regarding the nanomaterials characterization and potential risks to human and animal health, as well as to the environment.
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spelling Use of nanoparticles in cell tracing in advanced therapies: possibilities and challenges for clinical applicationUso de nanopartículas no rastreamento de células em terapias avançadas: possibilidades e desafios para a aplicação clínicaMagnetic NanoparticlesCell TackingStem CellsAdvanced TherapiesNanomedicineNanopartículas MagnéticasRastreamento CelularCélulas-troncoTerapias AvançadasNanomedicamentosIntroduction: Regulation and introduction of new advanced cellular technologies in clinics requires better knowledge on the used cells. One of the major challenges is the difficulty to accurately determine the mechanisms of cell activities when submitted to advanced therapies. Objective: Understand, using the cell tracking methods, the tissue distribution and the molecular response of cells exposed to advanced therapies. Methods: This work was done as an integrated review of data collected in international data-bases and of legislations concerning the clinical use of nanoparticles. Results: Nanotechnology is a very useful tool for cell tracking in vivo, and several nanoparticles have been already approved for clinical use; they can be incorporated into cells and visualized by magnetic resonance imaging. Conclusions: The perspectives on the use of nanomedicines for cellular tracking in medical clinic are promising, requiring elaboration and approval of laws, guides and norms to orient the industrial sectors, regarding the nanomaterials characterization and potential risks to human and animal health, as well as to the environment.Introdução: Para uma regulamentação específica e implementação das novas tecnologias avançadas na clínica médica, é preciso refinar o conhecimento sobre as células utilizadas. Um dos maiores desafios está na dificuldade em determinar os mecanismos de funcionamento das células após a terapia. Objetivo: Compreender, usando os métodos de rastreamento celular em pacientes, a distribuição e a função de células usadas em terapias avançadas. Método: Este trabalho foi elaborado pelo levantamento de artigos científicos nas bases de dados internacionais e da legislação vigente sobre a utilização clínica das nanopartículas. Resultados: Constatamos que a nanotecnologia já é uma ferramenta de grande utilidade, pois diversas nanopartículas magnéticas já são aprovadas para uso clínico; elas podem ser incorporadas por células e visualizadas por imagens de ressonância magnética. O presente texto discute as perspectivas sobre uso de nanomedicamentos para rastreamento celular na clínica médica. Conclusões: A utilização das nanopartículas necessita a elaboração e aprovação de leis, guias e normas que orientem a indústria, como outros setores, sobre a caracterização dos nanomateriais e potenciais riscos à saúde humana, animal e ao meio ambiente.Instituto Nacional de Controle de Qualidade em Saúde2018-02-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion"Peer-reviewed article""Artículo revisado por pares""Artigo avaliado pelos pares"application/pdfapplication/pdfhttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/106710.22239/2317-269X.01067Health Surveillance under Debate: Society, Science & Technology ; Vol. 6 No. 1 (2018): February - Tecnologias celulares avançadas: desafios biotecnológicos e regulatórios; 56-63Vigilancia en Salud en Debate: Sociedad, Ciencia y Tecnología; Vol. 6 Núm. 1 (2018): Febrero - Tecnologias celulares avançadas: desafios biotecnológicos e regulatórios; 56-63Vigil Sanit Debate, Rio de Janeiro; v. 6 n. 1 (2018): Fevereiro - Tecnologias celulares avançadas: desafios biotecnológicos e regulatórios; 56-632317-269Xreponame:Vigilância Sanitária em Debateinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporenghttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/1067/429https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/1067/557Copyright (c) 2018 Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia (Health Surveillance under Debate: Society, Science & Technology) – Visa em Debatehttps://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessJasmin, .Borojevic, Radovan2023-06-27T15:07:41Zoai:ojs.visaemdebate.incqs.fiocruz.br:article/1067Revistahttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebatePUBhttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/oaiincqs.visaemdebate@fiocruz.br || gisele.neves@fiocruz.br2317-269X2317-269Xopendoar:2023-06-27T15:07:41Vigilância Sanitária em Debate - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Use of nanoparticles in cell tracing in advanced therapies: possibilities and challenges for clinical application
Uso de nanopartículas no rastreamento de células em terapias avançadas: possibilidades e desafios para a aplicação clínica
title Use of nanoparticles in cell tracing in advanced therapies: possibilities and challenges for clinical application
spellingShingle Use of nanoparticles in cell tracing in advanced therapies: possibilities and challenges for clinical application
Jasmin, .
Magnetic Nanoparticles
Cell Tacking
Stem Cells
Advanced Therapies
Nanomedicine
Nanopartículas Magnéticas
Rastreamento Celular
Células-tronco
Terapias Avançadas
Nanomedicamentos
title_short Use of nanoparticles in cell tracing in advanced therapies: possibilities and challenges for clinical application
title_full Use of nanoparticles in cell tracing in advanced therapies: possibilities and challenges for clinical application
title_fullStr Use of nanoparticles in cell tracing in advanced therapies: possibilities and challenges for clinical application
title_full_unstemmed Use of nanoparticles in cell tracing in advanced therapies: possibilities and challenges for clinical application
title_sort Use of nanoparticles in cell tracing in advanced therapies: possibilities and challenges for clinical application
author Jasmin, .
author_facet Jasmin, .
Borojevic, Radovan
author_role author
author2 Borojevic, Radovan
author2_role author
dc.contributor.author.fl_str_mv Jasmin, .
Borojevic, Radovan
dc.subject.por.fl_str_mv Magnetic Nanoparticles
Cell Tacking
Stem Cells
Advanced Therapies
Nanomedicine
Nanopartículas Magnéticas
Rastreamento Celular
Células-tronco
Terapias Avançadas
Nanomedicamentos
topic Magnetic Nanoparticles
Cell Tacking
Stem Cells
Advanced Therapies
Nanomedicine
Nanopartículas Magnéticas
Rastreamento Celular
Células-tronco
Terapias Avançadas
Nanomedicamentos
description Introduction: Regulation and introduction of new advanced cellular technologies in clinics requires better knowledge on the used cells. One of the major challenges is the difficulty to accurately determine the mechanisms of cell activities when submitted to advanced therapies. Objective: Understand, using the cell tracking methods, the tissue distribution and the molecular response of cells exposed to advanced therapies. Methods: This work was done as an integrated review of data collected in international data-bases and of legislations concerning the clinical use of nanoparticles. Results: Nanotechnology is a very useful tool for cell tracking in vivo, and several nanoparticles have been already approved for clinical use; they can be incorporated into cells and visualized by magnetic resonance imaging. Conclusions: The perspectives on the use of nanomedicines for cellular tracking in medical clinic are promising, requiring elaboration and approval of laws, guides and norms to orient the industrial sectors, regarding the nanomaterials characterization and potential risks to human and animal health, as well as to the environment.
publishDate 2018
dc.date.none.fl_str_mv 2018-02-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
"Peer-reviewed article"
"Artículo revisado por pares"
"Artigo avaliado pelos pares"
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/1067
10.22239/2317-269X.01067
url https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/1067
identifier_str_mv 10.22239/2317-269X.01067
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/1067/429
https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/1067/557
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Instituto Nacional de Controle de Qualidade em Saúde
publisher.none.fl_str_mv Instituto Nacional de Controle de Qualidade em Saúde
dc.source.none.fl_str_mv Health Surveillance under Debate: Society, Science & Technology ; Vol. 6 No. 1 (2018): February - Tecnologias celulares avançadas: desafios biotecnológicos e regulatórios; 56-63
Vigilancia en Salud en Debate: Sociedad, Ciencia y Tecnología; Vol. 6 Núm. 1 (2018): Febrero - Tecnologias celulares avançadas: desafios biotecnológicos e regulatórios; 56-63
Vigil Sanit Debate, Rio de Janeiro; v. 6 n. 1 (2018): Fevereiro - Tecnologias celulares avançadas: desafios biotecnológicos e regulatórios; 56-63
2317-269X
reponame:Vigilância Sanitária em Debate
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Vigilância Sanitária em Debate
collection Vigilância Sanitária em Debate
repository.name.fl_str_mv Vigilância Sanitária em Debate - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv incqs.visaemdebate@fiocruz.br || gisele.neves@fiocruz.br
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