PEDIATRIC MULTISYSTEM INFLAMMATORY SYNDROME (MISC-C) TEMPORALLY ASSOCIATED WITH COVID-19

• Autor(a) principal: Casimiro Alves Dias, Eliane Cristina
• Data de Publicação: 2020
• Outros Autores: Azevedo, Carolina Dias, Maciel da Silva, Gabriel Fernandes, Silva, Gabriela Barbosa e, Silva, Ligia de Lima e
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Científica da Faculdade de Medicina de Campos
• Texto Completo: https://www.fmc.br/ojs/index.php/RCFMC/article/view/408
• topic: COVID-19; Doença de Kawasaki; Síndrome Inflamatória; SARS-CoV-2; Pediatria.; COVID-19; Kawasaki Disease; Inflammatory Syndrome; SARS-CoV-2; Pediatrics.

Introduction: The COVID-19 pandemic is less prevalent in the pediatric population when compared to the adult, with only 2% of cases under 20 years old. Recently, SARS-CoV-2 infection in children and adolescents is being associated with Pediatric Multisystemic Inflammatory Syndrome (SIM-P), Kawasaki-like disease. Objective: To report the occurrence of one of the clinical presentations of COVID-19 in childhood, SIM-P, highlighting its clinical, laboratory and clinical management. Case Description: Female, 9 years old, admitted with abdominal pain and fever for three days, in addition to home contact with those infected with SARS-CoV-2 in the last 30 days. She was feverish, with overweight and distended abdomen in the epigastric region. It evolved with erythematous macules on the back, edema and cleft lip, arthralgia, myalgia, vomiting, subconjunctival hemorrhage, raspberry tongue, sweating, tachydyspnea and dizziness. Tests with hemoglobin of 11.4 g/dL, 4,200 leukocytes, C-reactive protein of 18 mg/dL, computed tomography of the chest with small lymph nodes in the pre-vascular space. He received 1.5 mg/kg/day of Human Immunoglobulin with rapid regression and clinical improvement. Discussion: SIM-P occurs within days to weeks after an acute SARS-CoV-2 infection. Its clinical manifestations resemble Kawasaki's disease. In most cases, the SARS-CoV-2 PCR test is positive, showing recent infection, occurring in older children, with exuberant inflammatory markers and multiple organ dysfunction. Conclusion: Additional epidemiological and clinical studies are needed to better understand the pathophysiology of this new syndrome. Although rare, it is necessary to alert the pediatric community to expand and optimize recognition with early treatment.