Multisystem inflammatory syndrome in children: a case series

• Autor(a) principal: Gaspar,Arianne Ditzel
• Data de Publicação: 2022
• Outros Autores: Kuzma,Gabriela de Sio Puetter, Amancio,Luana, Floriani,Idilla, Bezerra,Vinicius Neves, Bortolon,Gabriela Cristina, de Siqueira,Ana Paula Viana, Machado,Maura Peruchi, Machado,Ana Cristina dos Santos, Camargo,Camila Faversani, João,Paulo Ramos David
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Paulista de Pediatria (Ed. Português. Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-05822022000100429
• topic: COVID-19; SARS-CoV-2 infection; SARS-CoV-2; Kawasaki Disease; Pediatrics

Abstract Objective: To describe a case series of multisystem inflammatory syndrome in children (MIS-C) in a pediatric tertiary hospital. Methods: Patients under the age of 18 years who met MIS-C criteria of the Brazilian Ministry of Health (MH) and/or the Royal College of Paediatrics and Child Health (RCPCH) were included. A retrospective analysis was carried out by reviewing medical records and complementary exams. Results: Six pediatric patients with mean age of 126 months were admitted with fever associated with multisystem involvement: all of them had abdominal pain and diarrhea and two underwent appendectomy; 100% had coagulopathy and increased inflammatory markers; 83% had cardiovascular impairment and 60% required vasoactive drugs; 83% had mucocutaneous symptoms and 50% required ventilatory support by invasive mechanical ventilation or non-invasive ventilation. One patient showed coronary artery dilation on echocardiogram. All patients received empiric antibiotic therapies. SARS-CoV-2 IgG testing was positive in five patients. Treatment was performed after excluding infectious causes: five patients (83%) received intravenous immunoglobulin, five patients (83%) pulse methylprednisolone therapy and one (16%) Tocilizumab. One patient died. The average length of stay in Pediatric Intensive Care Unit (PICU) was seven days. Conclusions: These cases are added to the literature in construction of this emerging condition. Early diagnosis should be considered due to its potential severity.