Integrins acting in cell adhesion, migration and cell signaling: association with pathologies and clinical studies.

Detalhes bibliográficos
Autor(a) principal: Ferraz, Francielle Bonet
Data de Publicação: 2014
Outros Autores: Fernandez, Jorge Hernandez
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Científica da Faculdade de Medicina de Campos
Texto Completo: https://www.fmc.br/ojs/index.php/RCFMC/article/view/48
Resumo: Integrins are important agents in communication between the cytoskeleton and plasma proteins or extracellular matrix intermediating cell-to-cell adhesion with other membrane proteins. Besides the adhesion function, integrin are recognized signaling molecules capable of performing transduction messages by classical pathways signaling thanks to their molecular structure. Thus, the integrins are consider as key modulators of cellular proliferation, migration, longevity, motility, and further, keep specific functions of cell differentiation. This review presents pertinent information about integrin complexity in cell signaling pathways, adhesion, migration and a key role in the hematopoietic system, especially the immune system. As a complex system, any failure provides greater opportunities for pathologies development. Thus, anomalies in integrinmediated signaling might contribute to different disease states, metastasis, angiogenesis and inflammatory diseases. Finally, some antagonists of integrins that are involved in clinical trials and new therapies are exemplified.
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spelling Integrins acting in cell adhesion, migration and cell signaling: association with pathologies and clinical studies.Integrinas na adesão, migração e sinalização celular: associação com patologias e estudos clínicos.IntegrinasTransdução de sinalAdesão celularMigração celularEstudos clínicosIntegrinsSignal transductionCell adhesionCell migrationClinical studiesIntegrins are important agents in communication between the cytoskeleton and plasma proteins or extracellular matrix intermediating cell-to-cell adhesion with other membrane proteins. Besides the adhesion function, integrin are recognized signaling molecules capable of performing transduction messages by classical pathways signaling thanks to their molecular structure. Thus, the integrins are consider as key modulators of cellular proliferation, migration, longevity, motility, and further, keep specific functions of cell differentiation. This review presents pertinent information about integrin complexity in cell signaling pathways, adhesion, migration and a key role in the hematopoietic system, especially the immune system. As a complex system, any failure provides greater opportunities for pathologies development. Thus, anomalies in integrinmediated signaling might contribute to different disease states, metastasis, angiogenesis and inflammatory diseases. Finally, some antagonists of integrins that are involved in clinical trials and new therapies are exemplified.Integrinas são intermediadoras na comunicação entre o citoesqueleto celular e proteínas plasmáticas ou da matriz extracelular por meio da adesão célula-a-célula através de interações com outras proteínas de membrana. Além da função de adesão, as integrinas são reconhecidas moléculas de sinalização capazes de realizar a transdução de mensagens por vias de sinalização clássica, graças a sua estrutura molecular. Desse modo, as integrinas podem ser consideradas moduladores chave da proliferação, migração, longevidade, migração e ainda, a manutenção das funções específicas de diferenciação celular. Esta revisão aborda informações pertinentes de como as integrinas funcionam de modo complexo dentro de vias de sinalização, de adesão, do citoesqueleto e desempenham papel fundamental no sistema hematopoiético, especialmente no sistema imune. Como sistema complexo, qualquer falha oferece maiores oportunidades para o desenvolvimento de patologias. Desse modo, aberrações na sinalização mediada pelas integrinas podem contribuir para diferentes estados patológicos, como metástase, angiogênese e doenças inflamatórias. Por fim, são exemplificados alguns antagonistas de integrinas que estão envolvidos em estudos clínicos como novas terapiasFaculdade de Medicina de Campos (FMC)2014-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.fmc.br/ojs/index.php/RCFMC/article/view/4810.29184/1980-7813.rcfmc.48.vol.9.n2.2014Scientific Journal of the Medical School of Campos; Vol. 9 No. 2 (2014); 25-34Revista Científica da Faculdade de Medicina de Campos; v. 9 n. 2 (2014); 25-341980-7813reponame:Revista Científica da Faculdade de Medicina de Camposinstname:Faculdade de Medicina de Campos (FMC)instacron:FMCporhttps://www.fmc.br/ojs/index.php/RCFMC/article/view/48/40Copyright (c) 2014 Revista Científica da Faculdade de Medicina de Camposinfo:eu-repo/semantics/openAccessFerraz, Francielle BonetFernandez, Jorge Hernandez2017-07-24T02:24:21Zoai:ojs.www.fmc.br:article/48Revistahttps://www.fmc.br/ojs/index.php/RCFMC/PRIhttps://www.fmc.br/ojs/index.php/RCFMC/oai||revista@fmc.br1980-78131980-7813opendoar:2017-07-24T02:24:21Revista Científica da Faculdade de Medicina de Campos - Faculdade de Medicina de Campos (FMC)false
dc.title.none.fl_str_mv Integrins acting in cell adhesion, migration and cell signaling: association with pathologies and clinical studies.
Integrinas na adesão, migração e sinalização celular: associação com patologias e estudos clínicos.
title Integrins acting in cell adhesion, migration and cell signaling: association with pathologies and clinical studies.
spellingShingle Integrins acting in cell adhesion, migration and cell signaling: association with pathologies and clinical studies.
Ferraz, Francielle Bonet
Integrinas
Transdução de sinal
Adesão celular
Migração celular
Estudos clínicos
Integrins
Signal transduction
Cell adhesion
Cell migration
Clinical studies
title_short Integrins acting in cell adhesion, migration and cell signaling: association with pathologies and clinical studies.
title_full Integrins acting in cell adhesion, migration and cell signaling: association with pathologies and clinical studies.
title_fullStr Integrins acting in cell adhesion, migration and cell signaling: association with pathologies and clinical studies.
title_full_unstemmed Integrins acting in cell adhesion, migration and cell signaling: association with pathologies and clinical studies.
title_sort Integrins acting in cell adhesion, migration and cell signaling: association with pathologies and clinical studies.
author Ferraz, Francielle Bonet
author_facet Ferraz, Francielle Bonet
Fernandez, Jorge Hernandez
author_role author
author2 Fernandez, Jorge Hernandez
author2_role author
dc.contributor.author.fl_str_mv Ferraz, Francielle Bonet
Fernandez, Jorge Hernandez
dc.subject.por.fl_str_mv Integrinas
Transdução de sinal
Adesão celular
Migração celular
Estudos clínicos
Integrins
Signal transduction
Cell adhesion
Cell migration
Clinical studies
topic Integrinas
Transdução de sinal
Adesão celular
Migração celular
Estudos clínicos
Integrins
Signal transduction
Cell adhesion
Cell migration
Clinical studies
description Integrins are important agents in communication between the cytoskeleton and plasma proteins or extracellular matrix intermediating cell-to-cell adhesion with other membrane proteins. Besides the adhesion function, integrin are recognized signaling molecules capable of performing transduction messages by classical pathways signaling thanks to their molecular structure. Thus, the integrins are consider as key modulators of cellular proliferation, migration, longevity, motility, and further, keep specific functions of cell differentiation. This review presents pertinent information about integrin complexity in cell signaling pathways, adhesion, migration and a key role in the hematopoietic system, especially the immune system. As a complex system, any failure provides greater opportunities for pathologies development. Thus, anomalies in integrinmediated signaling might contribute to different disease states, metastasis, angiogenesis and inflammatory diseases. Finally, some antagonists of integrins that are involved in clinical trials and new therapies are exemplified.
publishDate 2014
dc.date.none.fl_str_mv 2014-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.fmc.br/ojs/index.php/RCFMC/article/view/48
10.29184/1980-7813.rcfmc.48.vol.9.n2.2014
url https://www.fmc.br/ojs/index.php/RCFMC/article/view/48
identifier_str_mv 10.29184/1980-7813.rcfmc.48.vol.9.n2.2014
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.fmc.br/ojs/index.php/RCFMC/article/view/48/40
dc.rights.driver.fl_str_mv Copyright (c) 2014 Revista Científica da Faculdade de Medicina de Campos
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2014 Revista Científica da Faculdade de Medicina de Campos
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Medicina de Campos (FMC)
publisher.none.fl_str_mv Faculdade de Medicina de Campos (FMC)
dc.source.none.fl_str_mv Scientific Journal of the Medical School of Campos; Vol. 9 No. 2 (2014); 25-34
Revista Científica da Faculdade de Medicina de Campos; v. 9 n. 2 (2014); 25-34
1980-7813
reponame:Revista Científica da Faculdade de Medicina de Campos
instname:Faculdade de Medicina de Campos (FMC)
instacron:FMC
instname_str Faculdade de Medicina de Campos (FMC)
instacron_str FMC
institution FMC
reponame_str Revista Científica da Faculdade de Medicina de Campos
collection Revista Científica da Faculdade de Medicina de Campos
repository.name.fl_str_mv Revista Científica da Faculdade de Medicina de Campos - Faculdade de Medicina de Campos (FMC)
repository.mail.fl_str_mv ||revista@fmc.br
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