Current Concepts in Endocrinology for Clinicians and Medical Students. Hashimoto’s Thyroiditis: clinical and subclinical thyroid dysfunction

Detalhes bibliográficos
Autor(a) principal: Travassos Neto, Paulo
Data de Publicação: 2018
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Científica da Faculdade de Medicina de Campos
Texto Completo: https://www.fmc.br/ojs/index.php/RCFMC/article/view/224
Resumo: Hashimoto’s thyroiditis (HT) is an autoimmune and inflammatory disease in which antibodies are directed against the thyroid gland leading to chronic inflammation and hypothyroidism. The autoimmunity against thyroid antigens can be associated to genetic background and environmental factors. Thyroid peroxidase (TPO) and thyroglobulin (TG) are the major autoantigens for characterizing the disease. And the pathogenic mechanism is related to the activation of autoreactive CD4+ T cells, CD8+ cytotoxic T cells and antithyroid antibody producing-B cells. The treatment for hypothyroidism is based on thyroid hormone replacement, the levothyroxine. This review briefly discusses the clinical and pathogenic profile of HT and the importance of a correct diagnostics.
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spelling Current Concepts in Endocrinology for Clinicians and Medical Students. Hashimoto’s Thyroiditis: clinical and subclinical thyroid dysfunctionConceitos atuais na endocrinologia para os clínicos e estudantes de Medicina Tireoidite de Hashimoto: disfunção tireoidiana clínica e subclínicaHashimoto’s thyroiditis, hypothyroidism, diagnostic, treatmentHashimoto’s thyroiditis (HT) is an autoimmune and inflammatory disease in which antibodies are directed against the thyroid gland leading to chronic inflammation and hypothyroidism. The autoimmunity against thyroid antigens can be associated to genetic background and environmental factors. Thyroid peroxidase (TPO) and thyroglobulin (TG) are the major autoantigens for characterizing the disease. And the pathogenic mechanism is related to the activation of autoreactive CD4+ T cells, CD8+ cytotoxic T cells and antithyroid antibody producing-B cells. The treatment for hypothyroidism is based on thyroid hormone replacement, the levothyroxine. This review briefly discusses the clinical and pathogenic profile of HT and the importance of a correct diagnostics.Faculdade de Medicina de Campos (FMC)2018-12-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.fmc.br/ojs/index.php/RCFMC/article/view/22410.29184/1980-7813.rcfmc.224.vol.13.n2.2018Scientific Journal of the Medical School of Campos; Vol. 13 No. 2 (2018); 38-42Revista Científica da Faculdade de Medicina de Campos; v. 13 n. 2 (2018); 38-421980-7813reponame:Revista Científica da Faculdade de Medicina de Camposinstname:Faculdade de Medicina de Campos (FMC)instacron:FMCporhttps://www.fmc.br/ojs/index.php/RCFMC/article/view/224/181Copyright (c) 2019 Revista Científica da Faculdade de Medicina de Camposinfo:eu-repo/semantics/openAccessTravassos Neto, Paulo2021-01-06T19:41:43Zoai:ojs.www.fmc.br:article/224Revistahttps://www.fmc.br/ojs/index.php/RCFMC/PRIhttps://www.fmc.br/ojs/index.php/RCFMC/oai||revista@fmc.br1980-78131980-7813opendoar:2021-01-06T19:41:43Revista Científica da Faculdade de Medicina de Campos - Faculdade de Medicina de Campos (FMC)false
dc.title.none.fl_str_mv Current Concepts in Endocrinology for Clinicians and Medical Students. Hashimoto’s Thyroiditis: clinical and subclinical thyroid dysfunction
Conceitos atuais na endocrinologia para os clínicos e estudantes de Medicina Tireoidite de Hashimoto: disfunção tireoidiana clínica e subclínica
title Current Concepts in Endocrinology for Clinicians and Medical Students. Hashimoto’s Thyroiditis: clinical and subclinical thyroid dysfunction
spellingShingle Current Concepts in Endocrinology for Clinicians and Medical Students. Hashimoto’s Thyroiditis: clinical and subclinical thyroid dysfunction
Travassos Neto, Paulo
Hashimoto’s thyroiditis, hypothyroidism, diagnostic, treatment
title_short Current Concepts in Endocrinology for Clinicians and Medical Students. Hashimoto’s Thyroiditis: clinical and subclinical thyroid dysfunction
title_full Current Concepts in Endocrinology for Clinicians and Medical Students. Hashimoto’s Thyroiditis: clinical and subclinical thyroid dysfunction
title_fullStr Current Concepts in Endocrinology for Clinicians and Medical Students. Hashimoto’s Thyroiditis: clinical and subclinical thyroid dysfunction
title_full_unstemmed Current Concepts in Endocrinology for Clinicians and Medical Students. Hashimoto’s Thyroiditis: clinical and subclinical thyroid dysfunction
title_sort Current Concepts in Endocrinology for Clinicians and Medical Students. Hashimoto’s Thyroiditis: clinical and subclinical thyroid dysfunction
author Travassos Neto, Paulo
author_facet Travassos Neto, Paulo
author_role author
dc.contributor.author.fl_str_mv Travassos Neto, Paulo
dc.subject.por.fl_str_mv Hashimoto’s thyroiditis, hypothyroidism, diagnostic, treatment
topic Hashimoto’s thyroiditis, hypothyroidism, diagnostic, treatment
description Hashimoto’s thyroiditis (HT) is an autoimmune and inflammatory disease in which antibodies are directed against the thyroid gland leading to chronic inflammation and hypothyroidism. The autoimmunity against thyroid antigens can be associated to genetic background and environmental factors. Thyroid peroxidase (TPO) and thyroglobulin (TG) are the major autoantigens for characterizing the disease. And the pathogenic mechanism is related to the activation of autoreactive CD4+ T cells, CD8+ cytotoxic T cells and antithyroid antibody producing-B cells. The treatment for hypothyroidism is based on thyroid hormone replacement, the levothyroxine. This review briefly discusses the clinical and pathogenic profile of HT and the importance of a correct diagnostics.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-21
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.fmc.br/ojs/index.php/RCFMC/article/view/224
10.29184/1980-7813.rcfmc.224.vol.13.n2.2018
url https://www.fmc.br/ojs/index.php/RCFMC/article/view/224
identifier_str_mv 10.29184/1980-7813.rcfmc.224.vol.13.n2.2018
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://www.fmc.br/ojs/index.php/RCFMC/article/view/224/181
dc.rights.driver.fl_str_mv Copyright (c) 2019 Revista Científica da Faculdade de Medicina de Campos
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2019 Revista Científica da Faculdade de Medicina de Campos
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Medicina de Campos (FMC)
publisher.none.fl_str_mv Faculdade de Medicina de Campos (FMC)
dc.source.none.fl_str_mv Scientific Journal of the Medical School of Campos; Vol. 13 No. 2 (2018); 38-42
Revista Científica da Faculdade de Medicina de Campos; v. 13 n. 2 (2018); 38-42
1980-7813
reponame:Revista Científica da Faculdade de Medicina de Campos
instname:Faculdade de Medicina de Campos (FMC)
instacron:FMC
instname_str Faculdade de Medicina de Campos (FMC)
instacron_str FMC
institution FMC
reponame_str Revista Científica da Faculdade de Medicina de Campos
collection Revista Científica da Faculdade de Medicina de Campos
repository.name.fl_str_mv Revista Científica da Faculdade de Medicina de Campos - Faculdade de Medicina de Campos (FMC)
repository.mail.fl_str_mv ||revista@fmc.br
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