ACUTE AND CHRONIC EFFECT OF ESTRADIOL ON BLOOD PRESSURE IN POSTMENOPAUSAL WOMEN WITH CLASS II HYPERTENSION

• Autor(a) principal: Alecrin, Israel Nunes
• Data de Publicação: 2006
• Outros Autores: Aldrighi, José Mendes, Caldas, Márcia Azevedo, Silva, Elis Nogueira, de Oliveira, Paulo Rogério, Ramires, José Antônio Franchini
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Científica da Faculdade de Medicina de Campos
• Texto Completo: https://www.fmc.br/ojs/index.php/RCFMC/article/view/170

Background: hormonal replacement therapy (HRT) is widely used to relie ve menopausa[ symptoms and to prevent and treat osteopo rosis. But its effect on blood pressure in hypert ensive postmenopausal women is unknown. Objectives: To evaluate the acute and chronic effects of estradiol, in physiol ogic doses, in postmenopausal women withclass li hypert  en sion. Methods: Thirty four hypertensive postmenopausal women, mean age 58, 58 ±  3,5 years old , prospecti vely double blind randomized to receive placebo (n=17) or oral estradiol (n= 17), at dose of 1 mg per day, during 1.2 consecutive weeks. Blood pressur e was measured during basel in e, 90 minut es and 12 weeks after estradiol or placebo administ rat ion, usi ng automatic device the antihipertensive medication didn't change durin g the st udy. Results: baseli ne, 90 minute s and 12-weeks e st radiol levels 20 ± O, 85 ± 50 and 120 ± 74 pg/ ml (p <0,001) respectively in est r adiol group . ln pl acebogroup the estr adiol level was 20 ± O p g/ ml in the remoments. Baseline, 90 minutes and 12-weeksblood pressur e was 153 ± 22, 152 ± 17 and 149 ± 16 mmHgin estradiol groupand 95 ± 12, 91 ± 10 and 93 ± 9 mmHgin placebo group, respectively (p <ns). Conclusions:no diff erences statisti cs significant intra-group and among the groupsest radiol and placebo on blood pressur e in the three moments of t he st udy, what all owed to conclude us t hat HRT may not be harmful in hypertensive post menopausal women usinganti hypertensives medic ations.