Effect of aerobic exercise training on cGMP levels and blood pressure in treated hypertensive postmenopausal women
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/s1980-6574201700010001 http://hdl.handle.net/11449/157922 |
Resumo: | Abstract The second messenger cGMP has been largely studied as a therapeutic target in a variety of disorders such as erectile dysfunction, arterial hypertension and heart failure. Evidence has shown thatcGMP activators are less efficient in estrogen-deficiency animals, but no studies exist involving non-pharmacological approacheson NO/cGMP signaling pathway in hypertensive postmenopausal women. The aim of this study is to examine NO/cGMP pathway, redox state and blood pressure in trained treatedhypertensive (HT) postmenopausal women comparing with normotensive (NT) group. The rationale for that is most of HT patients is encouraged by physician to perform exercise associated with pharmacological treatments.Aerobic exercise training (AET) consisted of 24 sessions, 3 times/week.Parameters were evaluated at baseline and after AET for both groups (HT=28; NT=33).In treatedHT group, AET was significantly effective in increasing cGMP concentrations (28%) accompanied by an up-regulation of SOD (97%) and catalase activity (37%). In NT group, we found an increasein SOD activity (58%). TreatedHT postmenopausal women were still responsive to AET increasing cGMP levels and up-regulating antioxidant system. It should also be emphasized that these findings provide information on the circulating biomarkers that might delay the developing of cardiovascular events in this particular population. |
id |
UNSP_bbdaa581c7fd355b02d8462016ac29ac |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/157922 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Effect of aerobic exercise training on cGMP levels and blood pressure in treated hypertensive postmenopausal womenhypertension; postmenopause; aerobic exercise, cGMP, redox stateAbstract The second messenger cGMP has been largely studied as a therapeutic target in a variety of disorders such as erectile dysfunction, arterial hypertension and heart failure. Evidence has shown thatcGMP activators are less efficient in estrogen-deficiency animals, but no studies exist involving non-pharmacological approacheson NO/cGMP signaling pathway in hypertensive postmenopausal women. The aim of this study is to examine NO/cGMP pathway, redox state and blood pressure in trained treatedhypertensive (HT) postmenopausal women comparing with normotensive (NT) group. The rationale for that is most of HT patients is encouraged by physician to perform exercise associated with pharmacological treatments.Aerobic exercise training (AET) consisted of 24 sessions, 3 times/week.Parameters were evaluated at baseline and after AET for both groups (HT=28; NT=33).In treatedHT group, AET was significantly effective in increasing cGMP concentrations (28%) accompanied by an up-regulation of SOD (97%) and catalase activity (37%). In NT group, we found an increasein SOD activity (58%). TreatedHT postmenopausal women were still responsive to AET increasing cGMP levels and up-regulating antioxidant system. It should also be emphasized that these findings provide information on the circulating biomarkers that might delay the developing of cardiovascular events in this particular population.Universidade Estadual PaulistaUniversidade Estadual do Sudoeste da BahiaUniversidade Estadual de CampinasUniversidade Camilo Castelo BrancoUniversidade Estadual PaulistaUniversidade Estadual PaulistaUniversidade Estadual Paulista (Unesp)Universidade Estadual do Sudoeste da BahiaUniversidade Estadual de Campinas (UNICAMP)Universidade Camilo Castelo BrancoNovais, Iane PJarrete, Aline PPuga, Guilherme MAraujo, Hygor NDelbin, Maria AZanesco, Angelina2018-11-12T17:27:33Z2018-11-12T17:27:33Z2017-03-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-6application/pdfhttp://dx.doi.org/10.1590/s1980-6574201700010001Motriz: Revista de Educação Física. Universidade Estadual Paulista, v. 23, n. 1, p. 1-6, 2017.1980-6574http://hdl.handle.net/11449/15792210.1590/s1980-6574201700010001S1980-65742017000100001S1980-65742017000100001.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMotriz: Revista de Educação Física0,254info:eu-repo/semantics/openAccess2023-11-03T06:12:39Zoai:repositorio.unesp.br:11449/157922Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:50:51.315917Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of aerobic exercise training on cGMP levels and blood pressure in treated hypertensive postmenopausal women |
title |
Effect of aerobic exercise training on cGMP levels and blood pressure in treated hypertensive postmenopausal women |
spellingShingle |
Effect of aerobic exercise training on cGMP levels and blood pressure in treated hypertensive postmenopausal women Novais, Iane P hypertension; postmenopause; aerobic exercise, cGMP, redox state |
title_short |
Effect of aerobic exercise training on cGMP levels and blood pressure in treated hypertensive postmenopausal women |
title_full |
Effect of aerobic exercise training on cGMP levels and blood pressure in treated hypertensive postmenopausal women |
title_fullStr |
Effect of aerobic exercise training on cGMP levels and blood pressure in treated hypertensive postmenopausal women |
title_full_unstemmed |
Effect of aerobic exercise training on cGMP levels and blood pressure in treated hypertensive postmenopausal women |
title_sort |
Effect of aerobic exercise training on cGMP levels and blood pressure in treated hypertensive postmenopausal women |
author |
Novais, Iane P |
author_facet |
Novais, Iane P Jarrete, Aline P Puga, Guilherme M Araujo, Hygor N Delbin, Maria A Zanesco, Angelina |
author_role |
author |
author2 |
Jarrete, Aline P Puga, Guilherme M Araujo, Hygor N Delbin, Maria A Zanesco, Angelina |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual do Sudoeste da Bahia Universidade Estadual de Campinas (UNICAMP) Universidade Camilo Castelo Branco |
dc.contributor.author.fl_str_mv |
Novais, Iane P Jarrete, Aline P Puga, Guilherme M Araujo, Hygor N Delbin, Maria A Zanesco, Angelina |
dc.subject.por.fl_str_mv |
hypertension; postmenopause; aerobic exercise, cGMP, redox state |
topic |
hypertension; postmenopause; aerobic exercise, cGMP, redox state |
description |
Abstract The second messenger cGMP has been largely studied as a therapeutic target in a variety of disorders such as erectile dysfunction, arterial hypertension and heart failure. Evidence has shown thatcGMP activators are less efficient in estrogen-deficiency animals, but no studies exist involving non-pharmacological approacheson NO/cGMP signaling pathway in hypertensive postmenopausal women. The aim of this study is to examine NO/cGMP pathway, redox state and blood pressure in trained treatedhypertensive (HT) postmenopausal women comparing with normotensive (NT) group. The rationale for that is most of HT patients is encouraged by physician to perform exercise associated with pharmacological treatments.Aerobic exercise training (AET) consisted of 24 sessions, 3 times/week.Parameters were evaluated at baseline and after AET for both groups (HT=28; NT=33).In treatedHT group, AET was significantly effective in increasing cGMP concentrations (28%) accompanied by an up-regulation of SOD (97%) and catalase activity (37%). In NT group, we found an increasein SOD activity (58%). TreatedHT postmenopausal women were still responsive to AET increasing cGMP levels and up-regulating antioxidant system. It should also be emphasized that these findings provide information on the circulating biomarkers that might delay the developing of cardiovascular events in this particular population. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03-01 2018-11-12T17:27:33Z 2018-11-12T17:27:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/s1980-6574201700010001 Motriz: Revista de Educação Física. Universidade Estadual Paulista, v. 23, n. 1, p. 1-6, 2017. 1980-6574 http://hdl.handle.net/11449/157922 10.1590/s1980-6574201700010001 S1980-65742017000100001 S1980-65742017000100001.pdf |
url |
http://dx.doi.org/10.1590/s1980-6574201700010001 http://hdl.handle.net/11449/157922 |
identifier_str_mv |
Motriz: Revista de Educação Física. Universidade Estadual Paulista, v. 23, n. 1, p. 1-6, 2017. 1980-6574 10.1590/s1980-6574201700010001 S1980-65742017000100001 S1980-65742017000100001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Motriz: Revista de Educação Física 0,254 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-6 application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista |
publisher.none.fl_str_mv |
Universidade Estadual Paulista |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128708982079488 |