Comparação da microbiota oral de Candida sp. entre soropositivos para o HIV/doentes com AIDS e não portadores do vírus da imunodeficiência humana

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Gismar Monteiro Castro
Data de Publicação: 2007
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações da FAMERP
Texto Completo: http://bdtd.famerp.br/handle/tede/259
Resumo: Introduction: Candida albicans is as a human oral cavity colonizer. However, for the human immunodeficiency virus (HIV) serum-positive individuals and/or acquired immunodeficiency syndrome (AIDS) patients, it assumes opportunistic profile causing, amongst other clinical manifestations, oropharyngeal candidiasis. In the population, it is also isolated a group of species named Candida “non-albicans”, whose response in the presence of antifungical drugs can diverge. Objective: To study Candida sp. oral colonization in HIV-1 carriers/AIDS patients and their respective group, and describe its antifungal susceptibility profile. Methodology: Oral cavity samples, collected from 52 patients and respective controls were submitted micromorphological analysis of the strains. The antifungal susceptibility profile was evaluated by disc diffusion and by broth microdilution, for the following drugs: anfotericin-B, ketoconazole, itraconazole and fluconazole. Results: Candida sp. colonization/infection index was higher in the HIV/AIDS patients compared to their controls (p<0.05), and C. albicans was the most isolated species. Candida “non-albicans” frequency was similar for both studied groups, including C. dubliniensis absence. Single and mixed species colonization/infection rates were superior among HIV/AIDS dental prosthesis users in relation to those without such apparatus (P <0.05). the strains of the C. albicans isolated from the group patient regarding the isolated in the control group, showed higherthe fluconazole minimum inhibitory concentration (CIM) (P<0,01), smaller percentages of dose-dependent susceptibility (SDD) to ketoconazole (P<0,1) and greater ones for itraconazole (P<0,06). Higher percentages of SDDs to the same drugs were provided by Candida “non-albicans” isolated from healthy individuals. None of the isolated strains displayed resistant phenotype to fluconazole whereas they were all sensitive to anfotericin-B. Conclusions: The HIV/AIDS group, compared to the HIV serum-negative individuals, is more often colonized by Candida sp., without changes in the albicans x “non-albicans” ratio, and also with equivalent antifungal susceptibility profiles. C. dubliniensis does not colonize/infects the oral cavities of HIV infected subjects/AIDS patients, or their healthy controls, from São Paulo State Northwest region. HIV carriers/AIDS personnel who make use of dental prosthesis have higher Candida sp. oral cavity colonization/infection rates, needing, therefore, closest attention to their oral health.
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spelling Rossit, Andréa Regina BaptistaMachado, Ricardo Luiz DantasGiannini, Maria José Soares Mendes91864968672http://lattes.cnpq.br/3565006525694338Rodrigues, Gismar Monteiro Castro2016-05-20T18:39:11Z2007-09-13Rodrigues, Gismar Monteiro Castro. Comparação da microbiota oral de Candida sp. entre soropositivos para o HIV/doentes com AIDS e não portadores do vírus da imunodeficiência humana. 2007. 123 p. Dissertação( Programa de Pós-graduação em Ciências da Saúde) - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto.935http://bdtd.famerp.br/handle/tede/259Introduction: Candida albicans is as a human oral cavity colonizer. However, for the human immunodeficiency virus (HIV) serum-positive individuals and/or acquired immunodeficiency syndrome (AIDS) patients, it assumes opportunistic profile causing, amongst other clinical manifestations, oropharyngeal candidiasis. In the population, it is also isolated a group of species named Candida “non-albicans”, whose response in the presence of antifungical drugs can diverge. Objective: To study Candida sp. oral colonization in HIV-1 carriers/AIDS patients and their respective group, and describe its antifungal susceptibility profile. Methodology: Oral cavity samples, collected from 52 patients and respective controls were submitted micromorphological analysis of the strains. The antifungal susceptibility profile was evaluated by disc diffusion and by broth microdilution, for the following drugs: anfotericin-B, ketoconazole, itraconazole and fluconazole. Results: Candida sp. colonization/infection index was higher in the HIV/AIDS patients compared to their controls (p<0.05), and C. albicans was the most isolated species. Candida “non-albicans” frequency was similar for both studied groups, including C. dubliniensis absence. Single and mixed species colonization/infection rates were superior among HIV/AIDS dental prosthesis users in relation to those without such apparatus (P <0.05). the strains of the C. albicans isolated from the group patient regarding the isolated in the control group, showed higherthe fluconazole minimum inhibitory concentration (CIM) (P<0,01), smaller percentages of dose-dependent susceptibility (SDD) to ketoconazole (P<0,1) and greater ones for itraconazole (P<0,06). Higher percentages of SDDs to the same drugs were provided by Candida “non-albicans” isolated from healthy individuals. None of the isolated strains displayed resistant phenotype to fluconazole whereas they were all sensitive to anfotericin-B. Conclusions: The HIV/AIDS group, compared to the HIV serum-negative individuals, is more often colonized by Candida sp., without changes in the albicans x “non-albicans” ratio, and also with equivalent antifungal susceptibility profiles. C. dubliniensis does not colonize/infects the oral cavities of HIV infected subjects/AIDS patients, or their healthy controls, from São Paulo State Northwest region. HIV carriers/AIDS personnel who make use of dental prosthesis have higher Candida sp. oral cavity colonization/infection rates, needing, therefore, closest attention to their oral health.Introdução: Candida albicans é colonizadora da cavidade bucal humana sendo que em pacientes soropositivos para o vírus da imunodeficiência humana (HIV)/doentes com a síndrome da imunodeficiência adquirida (AIDS), assume perfil oportunista causando, dentre outras manifestações, a candidíase orofaríngea. Nesses indivíduos, são também isoladas as espécies “não albicans”, cuja resposta aos antifúngicos pode variar. Objetivo: Avaliar Candida sp. isolada a partir da microbiota oral de pacientes soropositivos para o HIV-1/doentes de AIDS e do respectivo grupo controle e descrever seu perfil de sensibilidade aos antifúngicos. Metodologia: As amostras obtidas a partir da mucosa oral de 52 pacientes e respectivos controles foram submetidas às análises micro-morfológicas das cepas. Para a pesquisa molecular de C. dubliniensis foi utilizada a reação em cadeia de polimerase. O perfil de sensibilidade antifúngica foi avaliado por difusão em disco e por microdiluição, frente à anfotericina B, cetoconazol, itraconazol e fluconazol... Resultados: O índice de colonização/infecção por Candida sp. foi maior no grupo HIV/AIDS comparado ao grupo controle (p<0,05), sendo C. albicans a espécie mais isolada. A freqüência de espécies “não albicans” foi similar em ambos os grupos, sem detecção de C. dubliniensis. O índice de colonização (única e mista) foi superior entre os pacientes HIV/AIDS usuários de próteses em relação aos não usuários (P <0,05). As cepas de C. albicans isoladas do grupo paciente em relação às isoladas do grupo controle apresentaram maior concentração inibitória mínima (CIM) frente ao fluconazol (P<0,01), menor percentual de sensibilidade dependente da dose (SDD) frente ao cetoconazol (P<0,1) e maior SDD para o itraconazol (P<0,06). Já Candida “não albicans”, isolada a partir de pessoas saudáveis, mostrou porcentagens maiores de SDD frente às mesmas drogas. Nenhuma levedura mostrou resistência às drogas avaliadas sendo unânime também a sensibilidade à anfotericina B. Conclusões: O grupo HIV/AIDS é mais colonizado por Candida sp. que os soronegativos para esse vírus, sem mudanças na proporção Candida albicans x “não albicans”, sendo que as cepas obtidas a partir de ambos grupos apresentam perfil de sensibilidade equivalente aos antifúngicos testados. C. dubliniensis não coloniza/infecta a mucosa oral dos portadores do HIV/doentes com AIDS ou de controles saudáveis da região Noroeste paulista. Portadores do HIV/doentes com AIDS que fazem uso de prótese dentária têm maiores chances de colonização/infecção da mucosa oral por tais levedu ras, necessitando, portanto, de maior atenção à saúde bucal.Submitted by Natalia Vieira (natalia.vieira@famerp.br) on 2016-05-20T18:39:11Z No. of bitstreams: 1 gismarmonteirocastrorodrigues_dissert.pdf: 1476033 bytes, checksum: 1656cd496debef44e68dd36fe6a5966c (MD5)Made available in DSpace on 2016-05-20T18:39:11Z (GMT). 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dc.title.por.fl_str_mv Comparação da microbiota oral de Candida sp. entre soropositivos para o HIV/doentes com AIDS e não portadores do vírus da imunodeficiência humana
title Comparação da microbiota oral de Candida sp. entre soropositivos para o HIV/doentes com AIDS e não portadores do vírus da imunodeficiência humana
spellingShingle Comparação da microbiota oral de Candida sp. entre soropositivos para o HIV/doentes com AIDS e não portadores do vírus da imunodeficiência humana
Rodrigues, Gismar Monteiro Castro
Communicable Diseases
Acquired Immunodeficiency Syndrome
Doenças Transmissíveis
HIV
Síndrome de Imunodeficiência Adquirida
CIENCIAS DA SAUDE::8765449414823306929::600
title_short Comparação da microbiota oral de Candida sp. entre soropositivos para o HIV/doentes com AIDS e não portadores do vírus da imunodeficiência humana
title_full Comparação da microbiota oral de Candida sp. entre soropositivos para o HIV/doentes com AIDS e não portadores do vírus da imunodeficiência humana
title_fullStr Comparação da microbiota oral de Candida sp. entre soropositivos para o HIV/doentes com AIDS e não portadores do vírus da imunodeficiência humana
title_full_unstemmed Comparação da microbiota oral de Candida sp. entre soropositivos para o HIV/doentes com AIDS e não portadores do vírus da imunodeficiência humana
title_sort Comparação da microbiota oral de Candida sp. entre soropositivos para o HIV/doentes com AIDS e não portadores do vírus da imunodeficiência humana
author Rodrigues, Gismar Monteiro Castro
author_facet Rodrigues, Gismar Monteiro Castro
author_role author
dc.contributor.advisor1.fl_str_mv Rossit, Andréa Regina Baptista
dc.contributor.referee1.fl_str_mv Machado, Ricardo Luiz Dantas
dc.contributor.referee2.fl_str_mv Giannini, Maria José Soares Mendes
dc.contributor.authorID.fl_str_mv 91864968672
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/3565006525694338
dc.contributor.author.fl_str_mv Rodrigues, Gismar Monteiro Castro
contributor_str_mv Rossit, Andréa Regina Baptista
Machado, Ricardo Luiz Dantas
Giannini, Maria José Soares Mendes
dc.subject.eng.fl_str_mv Communicable Diseases
Acquired Immunodeficiency Syndrome
topic Communicable Diseases
Acquired Immunodeficiency Syndrome
Doenças Transmissíveis
HIV
Síndrome de Imunodeficiência Adquirida
CIENCIAS DA SAUDE::8765449414823306929::600
dc.subject.por.fl_str_mv Doenças Transmissíveis
HIV
Síndrome de Imunodeficiência Adquirida
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE::8765449414823306929::600
description Introduction: Candida albicans is as a human oral cavity colonizer. However, for the human immunodeficiency virus (HIV) serum-positive individuals and/or acquired immunodeficiency syndrome (AIDS) patients, it assumes opportunistic profile causing, amongst other clinical manifestations, oropharyngeal candidiasis. In the population, it is also isolated a group of species named Candida “non-albicans”, whose response in the presence of antifungical drugs can diverge. Objective: To study Candida sp. oral colonization in HIV-1 carriers/AIDS patients and their respective group, and describe its antifungal susceptibility profile. Methodology: Oral cavity samples, collected from 52 patients and respective controls were submitted micromorphological analysis of the strains. The antifungal susceptibility profile was evaluated by disc diffusion and by broth microdilution, for the following drugs: anfotericin-B, ketoconazole, itraconazole and fluconazole. Results: Candida sp. colonization/infection index was higher in the HIV/AIDS patients compared to their controls (p<0.05), and C. albicans was the most isolated species. Candida “non-albicans” frequency was similar for both studied groups, including C. dubliniensis absence. Single and mixed species colonization/infection rates were superior among HIV/AIDS dental prosthesis users in relation to those without such apparatus (P <0.05). the strains of the C. albicans isolated from the group patient regarding the isolated in the control group, showed higherthe fluconazole minimum inhibitory concentration (CIM) (P<0,01), smaller percentages of dose-dependent susceptibility (SDD) to ketoconazole (P<0,1) and greater ones for itraconazole (P<0,06). Higher percentages of SDDs to the same drugs were provided by Candida “non-albicans” isolated from healthy individuals. None of the isolated strains displayed resistant phenotype to fluconazole whereas they were all sensitive to anfotericin-B. Conclusions: The HIV/AIDS group, compared to the HIV serum-negative individuals, is more often colonized by Candida sp., without changes in the albicans x “non-albicans” ratio, and also with equivalent antifungal susceptibility profiles. C. dubliniensis does not colonize/infects the oral cavities of HIV infected subjects/AIDS patients, or their healthy controls, from São Paulo State Northwest region. HIV carriers/AIDS personnel who make use of dental prosthesis have higher Candida sp. oral cavity colonization/infection rates, needing, therefore, closest attention to their oral health.
publishDate 2007
dc.date.issued.fl_str_mv 2007-09-13
dc.date.accessioned.fl_str_mv 2016-05-20T18:39:11Z
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dc.identifier.citation.fl_str_mv Rodrigues, Gismar Monteiro Castro. Comparação da microbiota oral de Candida sp. entre soropositivos para o HIV/doentes com AIDS e não portadores do vírus da imunodeficiência humana. 2007. 123 p. Dissertação( Programa de Pós-graduação em Ciências da Saúde) - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto.
dc.identifier.uri.fl_str_mv http://bdtd.famerp.br/handle/tede/259
dc.identifier.doi.por.fl_str_mv 935
identifier_str_mv Rodrigues, Gismar Monteiro Castro. Comparação da microbiota oral de Candida sp. entre soropositivos para o HIV/doentes com AIDS e não portadores do vírus da imunodeficiência humana. 2007. 123 p. Dissertação( Programa de Pós-graduação em Ciências da Saúde) - Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto.
935
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