Comparação da microbiota oral de Candida sp. entre soropositivos para o HIV/doentes com AIDS e não portadores do vírus da imunodeficiência humana

• Autor(a) principal: Rodrigues, Gismar Monteiro Castro
• Data de Publicação: 2007
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da FAMERP
• Texto Completo: http://bdtd.famerp.br/handle/tede/259
• topic: Communicable Diseases; Acquired Immunodeficiency Syndrome; Doenças Transmissíveis; HIV; Síndrome de Imunodeficiência Adquirida; CIENCIAS DA SAUDE::8765449414823306929::600

Introduction: Candida albicans is as a human oral cavity colonizer. However, for the human immunodeficiency virus (HIV) serum-positive individuals and/or acquired immunodeficiency syndrome (AIDS) patients, it assumes opportunistic profile causing, amongst other clinical manifestations, oropharyngeal candidiasis. In the population, it is also isolated a group of species named Candida “non-albicans”, whose response in the presence of antifungical drugs can diverge. Objective: To study Candida sp. oral colonization in HIV-1 carriers/AIDS patients and their respective group, and describe its antifungal susceptibility profile. Methodology: Oral cavity samples, collected from 52 patients and respective controls were submitted micromorphological analysis of the strains. The antifungal susceptibility profile was evaluated by disc diffusion and by broth microdilution, for the following drugs: anfotericin-B, ketoconazole, itraconazole and fluconazole. Results: Candida sp. colonization/infection index was higher in the HIV/AIDS patients compared to their controls (p<0.05), and C. albicans was the most isolated species. Candida “non-albicans” frequency was similar for both studied groups, including C. dubliniensis absence. Single and mixed species colonization/infection rates were superior among HIV/AIDS dental prosthesis users in relation to those without such apparatus (P <0.05). the strains of the C. albicans isolated from the group patient regarding the isolated in the control group, showed higherthe fluconazole minimum inhibitory concentration (CIM) (P<0,01), smaller percentages of dose-dependent susceptibility (SDD) to ketoconazole (P<0,1) and greater ones for itraconazole (P<0,06). Higher percentages of SDDs to the same drugs were provided by Candida “non-albicans” isolated from healthy individuals. None of the isolated strains displayed resistant phenotype to fluconazole whereas they were all sensitive to anfotericin-B. Conclusions: The HIV/AIDS group, compared to the HIV serum-negative individuals, is more often colonized by Candida sp., without changes in the albicans x “non-albicans” ratio, and also with equivalent antifungal susceptibility profiles. C. dubliniensis does not colonize/infects the oral cavities of HIV infected subjects/AIDS patients, or their healthy controls, from São Paulo State Northwest region. HIV carriers/AIDS personnel who make use of dental prosthesis have higher Candida sp. oral cavity colonization/infection rates, needing, therefore, closest attention to their oral health.