Antiretroviral changes during the first year of therapy
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/28886 |
Resumo: | Introduction: The Brazilian HIV/AIDS management and treatment guideline (PCDT), published in 2013, recommends and standardizes the use of highly active antiretroviral therapy (HAART) in all adult patients, in spite of LTCD4 count. This study aimed to analyze the first year of HAART use in patients from a reference center on HIV/AIDS management in Fortaleza, Ceará. Method: This descriptive study reviewed all prescription forms of antiretroviral regimens initiation and changes from January to July 2014. All antiretroviral regimen changes that occurred during the first year of therapy were evaluated. Data were analyzed with SPSS version 20. Mean, standard deviation and frequency, Student’s t and Mann-Whitney tests calculations were used, with significance at p<0.05. Results: From 527 patients initiating HAART, 16.5% (n=87) had a regimen change in the first year. These patients were mostly male (59.8%; n=52), aged 20 to 39 years, with only one HAART change (72.4%; n=63). Efavirenz was the most often changed drug, followed by tenofovir, zidovudine and lopinavir/ritonavir. Mean time of HAART changes was 120 days, with adverse reactions as the most prevalent cause. HAART was effective in decreasing viral load since second month of treatment (p=0.003) and increasing LTCD4 lymphocytes since fifth month (p<0.001). Conclusion: The main cause of initial HAART changes was adverse reaction and most patients had only one change in the HAART regimen. HAART prescription was in accordance to the PCDT from 2013. |
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Antiretroviral changes during the first year of therapyMudanças de terapia antirretroviral durante o primeiro ano de tratamentoSíndrome da Imunodeficiência AdquiridaAcquired Immunodeficiency SyndromeHIVIntroduction: The Brazilian HIV/AIDS management and treatment guideline (PCDT), published in 2013, recommends and standardizes the use of highly active antiretroviral therapy (HAART) in all adult patients, in spite of LTCD4 count. This study aimed to analyze the first year of HAART use in patients from a reference center on HIV/AIDS management in Fortaleza, Ceará. Method: This descriptive study reviewed all prescription forms of antiretroviral regimens initiation and changes from January to July 2014. All antiretroviral regimen changes that occurred during the first year of therapy were evaluated. Data were analyzed with SPSS version 20. Mean, standard deviation and frequency, Student’s t and Mann-Whitney tests calculations were used, with significance at p<0.05. Results: From 527 patients initiating HAART, 16.5% (n=87) had a regimen change in the first year. These patients were mostly male (59.8%; n=52), aged 20 to 39 years, with only one HAART change (72.4%; n=63). Efavirenz was the most often changed drug, followed by tenofovir, zidovudine and lopinavir/ritonavir. Mean time of HAART changes was 120 days, with adverse reactions as the most prevalent cause. HAART was effective in decreasing viral load since second month of treatment (p=0.003) and increasing LTCD4 lymphocytes since fifth month (p<0.001). Conclusion: The main cause of initial HAART changes was adverse reaction and most patients had only one change in the HAART regimen. HAART prescription was in accordance to the PCDT from 2013.Introdução: O Protocolo Clínico e Diretrizes Terapêuticas para manejo da infecção pelo HIV em adultos (PCDT) de 2013 recomenda e normatiza início de terapia antirretroviral (TARV) em pacientes com qualquer contagem de LTCD4. O objetivo do estudo foi analisar o primeiro ano de TARV de pacientes em acompanhamento em um centro de referência em HIV/AIDS de Fortaleza, Ceará. Método: O estudo descritivo revisou formulários de solicitação de início e modificação de TARV em pacientes que iniciaram tratamento entre janeiro e julho de 2014. Foram avaliadas todas as mudanças que ocorreram durante o primeiro ano de terapia. Os dados foram analisados no programa Statistical Package for the Social Sciences (SPSS) versão 20. Foram calculados médias, desvios padrão, frequências, testes t Student e Mann-Whitney, com significância de p<0,05. Resultados: Dos 527 pacientes que iniciaram TARV, 16,5% (n=87) realizaram troca no primeiro ano. A maioria era do sexo masculino (59,8%; n=52), de 20 a 39 anos, com apenas uma mudança da TARV (72,4%; n=63). Efavirenz foi o fármaco mais substituído, seguido por tenofovir, zidovudina e lopinavir/ritonavir. O tempo médio de ocorrência das modificações da TARV foi de 120 dias, tendo reações adversas como causas principais. TARV foi efetiva na queda da carga viral desde o 2ºmês de tratamento (p=0,003) e na elevação de LTCD4 desde o 5º mês (p<0,001). Conclusão: Os principais fatores envolvidos em modificações de TARV inicial foram reações adversas, com apenas uma mudança de esquema na maioria dos pacientes. O manejo da TARV estava de acordo com o PCDT de 2013. Palavras-chave: síndrome da imunodeficiência adquirida; terapia antirretroviral de alta atividade; vírus da imunodeficiência humanaRevista da Associação Médica Brasileira2018-01-04T18:20:02Z2018-01-04T18:20:02Z2017-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBANDEIRA, A. C. P. C. S. et al. Antiretroviral changes during the first year of therapy. Revista da Associação Médica Brasileira, São Paulo, v. 63, n.7, p. 606-612, jul. 2017.0104-4230 On-line1806-9282http://www.repositorio.ufc.br/handle/riufc/28886Bandeira, Antonio Carlos Policarpo Carmo SáElias, Darcielle Bruna DiasCavalcante, Malena GadelhaLima, Denise Girão LimaverdeTávora, Lara Gurgel Fernandesengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-17T17:02:09Zoai:repositorio.ufc.br:riufc/28886Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:52:42.679353Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Antiretroviral changes during the first year of therapy Mudanças de terapia antirretroviral durante o primeiro ano de tratamento |
title |
Antiretroviral changes during the first year of therapy |
spellingShingle |
Antiretroviral changes during the first year of therapy Bandeira, Antonio Carlos Policarpo Carmo Sá Síndrome da Imunodeficiência Adquirida Acquired Immunodeficiency Syndrome HIV |
title_short |
Antiretroviral changes during the first year of therapy |
title_full |
Antiretroviral changes during the first year of therapy |
title_fullStr |
Antiretroviral changes during the first year of therapy |
title_full_unstemmed |
Antiretroviral changes during the first year of therapy |
title_sort |
Antiretroviral changes during the first year of therapy |
author |
Bandeira, Antonio Carlos Policarpo Carmo Sá |
author_facet |
Bandeira, Antonio Carlos Policarpo Carmo Sá Elias, Darcielle Bruna Dias Cavalcante, Malena Gadelha Lima, Denise Girão Limaverde Távora, Lara Gurgel Fernandes |
author_role |
author |
author2 |
Elias, Darcielle Bruna Dias Cavalcante, Malena Gadelha Lima, Denise Girão Limaverde Távora, Lara Gurgel Fernandes |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Bandeira, Antonio Carlos Policarpo Carmo Sá Elias, Darcielle Bruna Dias Cavalcante, Malena Gadelha Lima, Denise Girão Limaverde Távora, Lara Gurgel Fernandes |
dc.subject.por.fl_str_mv |
Síndrome da Imunodeficiência Adquirida Acquired Immunodeficiency Syndrome HIV |
topic |
Síndrome da Imunodeficiência Adquirida Acquired Immunodeficiency Syndrome HIV |
description |
Introduction: The Brazilian HIV/AIDS management and treatment guideline (PCDT), published in 2013, recommends and standardizes the use of highly active antiretroviral therapy (HAART) in all adult patients, in spite of LTCD4 count. This study aimed to analyze the first year of HAART use in patients from a reference center on HIV/AIDS management in Fortaleza, Ceará. Method: This descriptive study reviewed all prescription forms of antiretroviral regimens initiation and changes from January to July 2014. All antiretroviral regimen changes that occurred during the first year of therapy were evaluated. Data were analyzed with SPSS version 20. Mean, standard deviation and frequency, Student’s t and Mann-Whitney tests calculations were used, with significance at p<0.05. Results: From 527 patients initiating HAART, 16.5% (n=87) had a regimen change in the first year. These patients were mostly male (59.8%; n=52), aged 20 to 39 years, with only one HAART change (72.4%; n=63). Efavirenz was the most often changed drug, followed by tenofovir, zidovudine and lopinavir/ritonavir. Mean time of HAART changes was 120 days, with adverse reactions as the most prevalent cause. HAART was effective in decreasing viral load since second month of treatment (p=0.003) and increasing LTCD4 lymphocytes since fifth month (p<0.001). Conclusion: The main cause of initial HAART changes was adverse reaction and most patients had only one change in the HAART regimen. HAART prescription was in accordance to the PCDT from 2013. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-07 2018-01-04T18:20:02Z 2018-01-04T18:20:02Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
BANDEIRA, A. C. P. C. S. et al. Antiretroviral changes during the first year of therapy. Revista da Associação Médica Brasileira, São Paulo, v. 63, n.7, p. 606-612, jul. 2017. 0104-4230 On-line 1806-9282 http://www.repositorio.ufc.br/handle/riufc/28886 |
identifier_str_mv |
BANDEIRA, A. C. P. C. S. et al. Antiretroviral changes during the first year of therapy. Revista da Associação Médica Brasileira, São Paulo, v. 63, n.7, p. 606-612, jul. 2017. 0104-4230 On-line 1806-9282 |
url |
http://www.repositorio.ufc.br/handle/riufc/28886 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Revista da Associação Médica Brasileira |
publisher.none.fl_str_mv |
Revista da Associação Médica Brasileira |
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reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
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UFC |
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UFC |
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Repositório Institucional da Universidade Federal do Ceará (UFC) |
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Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
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bu@ufc.br || repositorio@ufc.br |
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1813028980948729856 |