Antiretroviral changes during the first year of therapy

Detalhes bibliográficos
Autor(a) principal: Bandeira, Antonio Carlos Policarpo Carmo Sá
Data de Publicação: 2017
Outros Autores: Elias, Darcielle Bruna Dias, Cavalcante, Malena Gadelha, Lima, Denise Girão Limaverde, Távora, Lara Gurgel Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da Universidade Federal do Ceará (UFC)
Texto Completo: http://www.repositorio.ufc.br/handle/riufc/28886
Resumo: Introduction: The Brazilian HIV/AIDS management and treatment guideline (PCDT), published in 2013, recommends and standardizes the use of highly active antiretroviral therapy (HAART) in all adult patients, in spite of LTCD4 count. This study aimed to analyze the first year of HAART use in patients from a reference center on HIV/AIDS management in Fortaleza, Ceará. Method: This descriptive study reviewed all prescription forms of antiretroviral regimens initiation and changes from January to July 2014. All antiretroviral regimen changes that occurred during the first year of therapy were evaluated. Data were analyzed with SPSS version 20. Mean, standard deviation and frequency, Student’s t and Mann-Whitney tests calculations were used, with significance at p<0.05. Results: From 527 patients initiating HAART, 16.5% (n=87) had a regimen change in the first year. These patients were mostly male (59.8%; n=52), aged 20 to 39 years, with only one HAART change (72.4%; n=63). Efavirenz was the most often changed drug, followed by tenofovir, zidovudine and lopinavir/ritonavir. Mean time of HAART changes was 120 days, with adverse reactions as the most prevalent cause. HAART was effective in decreasing viral load since second month of treatment (p=0.003) and increasing LTCD4 lymphocytes since fifth month (p<0.001). Conclusion: The main cause of initial HAART changes was adverse reaction and most patients had only one change in the HAART regimen. HAART prescription was in accordance to the PCDT from 2013.
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spelling Antiretroviral changes during the first year of therapyMudanças de terapia antirretroviral durante o primeiro ano de tratamentoSíndrome da Imunodeficiência AdquiridaAcquired Immunodeficiency SyndromeHIVIntroduction: The Brazilian HIV/AIDS management and treatment guideline (PCDT), published in 2013, recommends and standardizes the use of highly active antiretroviral therapy (HAART) in all adult patients, in spite of LTCD4 count. This study aimed to analyze the first year of HAART use in patients from a reference center on HIV/AIDS management in Fortaleza, Ceará. Method: This descriptive study reviewed all prescription forms of antiretroviral regimens initiation and changes from January to July 2014. All antiretroviral regimen changes that occurred during the first year of therapy were evaluated. Data were analyzed with SPSS version 20. Mean, standard deviation and frequency, Student’s t and Mann-Whitney tests calculations were used, with significance at p<0.05. Results: From 527 patients initiating HAART, 16.5% (n=87) had a regimen change in the first year. These patients were mostly male (59.8%; n=52), aged 20 to 39 years, with only one HAART change (72.4%; n=63). Efavirenz was the most often changed drug, followed by tenofovir, zidovudine and lopinavir/ritonavir. Mean time of HAART changes was 120 days, with adverse reactions as the most prevalent cause. HAART was effective in decreasing viral load since second month of treatment (p=0.003) and increasing LTCD4 lymphocytes since fifth month (p<0.001). Conclusion: The main cause of initial HAART changes was adverse reaction and most patients had only one change in the HAART regimen. HAART prescription was in accordance to the PCDT from 2013.Introdução: O Protocolo Clínico e Diretrizes Terapêuticas para manejo da infecção pelo HIV em adultos (PCDT) de 2013 recomenda e normatiza início de terapia antirretroviral (TARV) em pacientes com qualquer contagem de LTCD4. O objetivo do estudo foi analisar o primeiro ano de TARV de pacientes em acompanhamento em um centro de referência em HIV/AIDS de Fortaleza, Ceará. Método: O estudo descritivo revisou formulários de solicitação de início e modificação de TARV em pacientes que iniciaram tratamento entre janeiro e julho de 2014. Foram avaliadas todas as mudanças que ocorreram durante o primeiro ano de terapia. Os dados foram analisados no programa Statistical Package for the Social Sciences (SPSS) versão 20. Foram calculados médias, desvios padrão, frequências, testes t Student e Mann-Whitney, com significância de p<0,05. Resultados: Dos 527 pacientes que iniciaram TARV, 16,5% (n=87) realizaram troca no primeiro ano. A maioria era do sexo masculino (59,8%; n=52), de 20 a 39 anos, com apenas uma mudança da TARV (72,4%; n=63). Efavirenz foi o fármaco mais substituído, seguido por tenofovir, zidovudina e lopinavir/ritonavir. O tempo médio de ocorrência das modificações da TARV foi de 120 dias, tendo reações adversas como causas principais. TARV foi efetiva na queda da carga viral desde o 2ºmês de tratamento (p=0,003) e na elevação de LTCD4 desde o 5º mês (p<0,001). Conclusão: Os principais fatores envolvidos em modificações de TARV inicial foram reações adversas, com apenas uma mudança de esquema na maioria dos pacientes. O manejo da TARV estava de acordo com o PCDT de 2013. Palavras-chave: síndrome da imunodeficiência adquirida; terapia antirretroviral de alta atividade; vírus da imunodeficiência humanaRevista da Associação Médica Brasileira2018-01-04T18:20:02Z2018-01-04T18:20:02Z2017-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfBANDEIRA, A. C. P. C. S. et al. Antiretroviral changes during the first year of therapy. Revista da Associação Médica Brasileira, São Paulo, v. 63, n.7, p. 606-612, jul. 2017.0104-4230 On-line1806-9282http://www.repositorio.ufc.br/handle/riufc/28886Bandeira, Antonio Carlos Policarpo Carmo SáElias, Darcielle Bruna DiasCavalcante, Malena GadelhaLima, Denise Girão LimaverdeTávora, Lara Gurgel Fernandesengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2019-01-17T17:02:09Zoai:repositorio.ufc.br:riufc/28886Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:52:42.679353Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false
dc.title.none.fl_str_mv Antiretroviral changes during the first year of therapy
Mudanças de terapia antirretroviral durante o primeiro ano de tratamento
title Antiretroviral changes during the first year of therapy
spellingShingle Antiretroviral changes during the first year of therapy
Bandeira, Antonio Carlos Policarpo Carmo Sá
Síndrome da Imunodeficiência Adquirida
Acquired Immunodeficiency Syndrome
HIV
title_short Antiretroviral changes during the first year of therapy
title_full Antiretroviral changes during the first year of therapy
title_fullStr Antiretroviral changes during the first year of therapy
title_full_unstemmed Antiretroviral changes during the first year of therapy
title_sort Antiretroviral changes during the first year of therapy
author Bandeira, Antonio Carlos Policarpo Carmo Sá
author_facet Bandeira, Antonio Carlos Policarpo Carmo Sá
Elias, Darcielle Bruna Dias
Cavalcante, Malena Gadelha
Lima, Denise Girão Limaverde
Távora, Lara Gurgel Fernandes
author_role author
author2 Elias, Darcielle Bruna Dias
Cavalcante, Malena Gadelha
Lima, Denise Girão Limaverde
Távora, Lara Gurgel Fernandes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Bandeira, Antonio Carlos Policarpo Carmo Sá
Elias, Darcielle Bruna Dias
Cavalcante, Malena Gadelha
Lima, Denise Girão Limaverde
Távora, Lara Gurgel Fernandes
dc.subject.por.fl_str_mv Síndrome da Imunodeficiência Adquirida
Acquired Immunodeficiency Syndrome
HIV
topic Síndrome da Imunodeficiência Adquirida
Acquired Immunodeficiency Syndrome
HIV
description Introduction: The Brazilian HIV/AIDS management and treatment guideline (PCDT), published in 2013, recommends and standardizes the use of highly active antiretroviral therapy (HAART) in all adult patients, in spite of LTCD4 count. This study aimed to analyze the first year of HAART use in patients from a reference center on HIV/AIDS management in Fortaleza, Ceará. Method: This descriptive study reviewed all prescription forms of antiretroviral regimens initiation and changes from January to July 2014. All antiretroviral regimen changes that occurred during the first year of therapy were evaluated. Data were analyzed with SPSS version 20. Mean, standard deviation and frequency, Student’s t and Mann-Whitney tests calculations were used, with significance at p<0.05. Results: From 527 patients initiating HAART, 16.5% (n=87) had a regimen change in the first year. These patients were mostly male (59.8%; n=52), aged 20 to 39 years, with only one HAART change (72.4%; n=63). Efavirenz was the most often changed drug, followed by tenofovir, zidovudine and lopinavir/ritonavir. Mean time of HAART changes was 120 days, with adverse reactions as the most prevalent cause. HAART was effective in decreasing viral load since second month of treatment (p=0.003) and increasing LTCD4 lymphocytes since fifth month (p<0.001). Conclusion: The main cause of initial HAART changes was adverse reaction and most patients had only one change in the HAART regimen. HAART prescription was in accordance to the PCDT from 2013.
publishDate 2017
dc.date.none.fl_str_mv 2017-07
2018-01-04T18:20:02Z
2018-01-04T18:20:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv BANDEIRA, A. C. P. C. S. et al. Antiretroviral changes during the first year of therapy. Revista da Associação Médica Brasileira, São Paulo, v. 63, n.7, p. 606-612, jul. 2017.
0104-4230 On-line
1806-9282
http://www.repositorio.ufc.br/handle/riufc/28886
identifier_str_mv BANDEIRA, A. C. P. C. S. et al. Antiretroviral changes during the first year of therapy. Revista da Associação Médica Brasileira, São Paulo, v. 63, n.7, p. 606-612, jul. 2017.
0104-4230 On-line
1806-9282
url http://www.repositorio.ufc.br/handle/riufc/28886
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Revista da Associação Médica Brasileira
publisher.none.fl_str_mv Revista da Associação Médica Brasileira
dc.source.none.fl_str_mv reponame:Repositório Institucional da Universidade Federal do Ceará (UFC)
instname:Universidade Federal do Ceará (UFC)
instacron:UFC
instname_str Universidade Federal do Ceará (UFC)
instacron_str UFC
institution UFC
reponame_str Repositório Institucional da Universidade Federal do Ceará (UFC)
collection Repositório Institucional da Universidade Federal do Ceará (UFC)
repository.name.fl_str_mv Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)
repository.mail.fl_str_mv bu@ufc.br || repositorio@ufc.br
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