Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD

Detalhes bibliográficos
Autor(a) principal: Cortelli,Sheila C
Data de Publicação: 2021
Outros Autores: Máximo,Priscila de Macedo, Peralta,Felipe S, Silva,Rodrigo Augusto da, Rovai,Emanuel S, Costa,Fernando O, Aquino,Davi R, Rodrigues,Edson, Cortelli,Jose R
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Dental Journal
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402021000200027
Resumo: Abstract The objective of this 9-month clinical study is to assess the impact of one-stage full-mouth disinfection (FMD) on salivary nitrite levels and systemic biomarkers and its correlation with total subgingival bacterial load in obese and non-obese patients with periodontitis. In total, 94 patients (55 obese and 39 non-obese) were initially evaluated, seven were lost during follow-up, resulting in 87 individuals at the end of the study. Outcomes were assessed at baseline, 3, 6, and 9 months post periodontal treatment by FMD. Salivary nitrite levels were determined using Griess reagent. Blood samples were collected to determine C-Reactive Protein (CRP), alkaline phosphatase and fasting blood glucose. Real-time PCR was used to determine the total subgingival bacterial load. FMD protocol resulted in increased salivary nitrite levels at 6- and 9-months post-treatment in the non-obese group (p<0.05). In obese individuals, FMD treatment led to an increase in salivary nitrite levels at 6 months (p<0.05); however, at 9 months, the nitrite levels returned to baseline levels. For both groups, the highest nitrite values were observed at 6 months. In addition, in both groups, FMD was associated with a decrease in biomarkers related to systemic inflammation and cardiovascular diseases, such as CRP (p<0.05) and alkaline phosphatase (p<0.05), and had no impact on the fasting blood glucose. This study demonstrates that obese patients with periodontitis present similar salivary nitrite levels when compared with non-obese individuals. FMD protocol resulted in increases in salivary nitrite levels and was associated with a positive impact on systemic biomarkers, regardless of obesity status.
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spelling Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMDObesity, NitritesBacteriaPeriodontal diseasesTherapeuticsAbstract The objective of this 9-month clinical study is to assess the impact of one-stage full-mouth disinfection (FMD) on salivary nitrite levels and systemic biomarkers and its correlation with total subgingival bacterial load in obese and non-obese patients with periodontitis. In total, 94 patients (55 obese and 39 non-obese) were initially evaluated, seven were lost during follow-up, resulting in 87 individuals at the end of the study. Outcomes were assessed at baseline, 3, 6, and 9 months post periodontal treatment by FMD. Salivary nitrite levels were determined using Griess reagent. Blood samples were collected to determine C-Reactive Protein (CRP), alkaline phosphatase and fasting blood glucose. Real-time PCR was used to determine the total subgingival bacterial load. FMD protocol resulted in increased salivary nitrite levels at 6- and 9-months post-treatment in the non-obese group (p<0.05). In obese individuals, FMD treatment led to an increase in salivary nitrite levels at 6 months (p<0.05); however, at 9 months, the nitrite levels returned to baseline levels. For both groups, the highest nitrite values were observed at 6 months. In addition, in both groups, FMD was associated with a decrease in biomarkers related to systemic inflammation and cardiovascular diseases, such as CRP (p<0.05) and alkaline phosphatase (p<0.05), and had no impact on the fasting blood glucose. This study demonstrates that obese patients with periodontitis present similar salivary nitrite levels when compared with non-obese individuals. FMD protocol resulted in increases in salivary nitrite levels and was associated with a positive impact on systemic biomarkers, regardless of obesity status.Fundação Odontológica de Ribeirão Preto2021-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402021000200027Brazilian Dental Journal v.32 n.2 2021reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/0103-6440202103782info:eu-repo/semantics/openAccessCortelli,Sheila CMáximo,Priscila de MacedoPeralta,Felipe SSilva,Rodrigo Augusto daRovai,Emanuel SCosta,Fernando OAquino,Davi RRodrigues,EdsonCortelli,Jose Reng2021-09-29T00:00:00Zoai:scielo:S0103-64402021000200027Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2021-09-29T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false
dc.title.none.fl_str_mv Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD
title Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD
spellingShingle Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD
Cortelli,Sheila C
Obesity, Nitrites
Bacteria
Periodontal diseases
Therapeutics
title_short Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD
title_full Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD
title_fullStr Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD
title_full_unstemmed Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD
title_sort Salivary nitrite and systemic biomarkers in obese individuals with periodontitis submitted to FMD
author Cortelli,Sheila C
author_facet Cortelli,Sheila C
Máximo,Priscila de Macedo
Peralta,Felipe S
Silva,Rodrigo Augusto da
Rovai,Emanuel S
Costa,Fernando O
Aquino,Davi R
Rodrigues,Edson
Cortelli,Jose R
author_role author
author2 Máximo,Priscila de Macedo
Peralta,Felipe S
Silva,Rodrigo Augusto da
Rovai,Emanuel S
Costa,Fernando O
Aquino,Davi R
Rodrigues,Edson
Cortelli,Jose R
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cortelli,Sheila C
Máximo,Priscila de Macedo
Peralta,Felipe S
Silva,Rodrigo Augusto da
Rovai,Emanuel S
Costa,Fernando O
Aquino,Davi R
Rodrigues,Edson
Cortelli,Jose R
dc.subject.por.fl_str_mv Obesity, Nitrites
Bacteria
Periodontal diseases
Therapeutics
topic Obesity, Nitrites
Bacteria
Periodontal diseases
Therapeutics
description Abstract The objective of this 9-month clinical study is to assess the impact of one-stage full-mouth disinfection (FMD) on salivary nitrite levels and systemic biomarkers and its correlation with total subgingival bacterial load in obese and non-obese patients with periodontitis. In total, 94 patients (55 obese and 39 non-obese) were initially evaluated, seven were lost during follow-up, resulting in 87 individuals at the end of the study. Outcomes were assessed at baseline, 3, 6, and 9 months post periodontal treatment by FMD. Salivary nitrite levels were determined using Griess reagent. Blood samples were collected to determine C-Reactive Protein (CRP), alkaline phosphatase and fasting blood glucose. Real-time PCR was used to determine the total subgingival bacterial load. FMD protocol resulted in increased salivary nitrite levels at 6- and 9-months post-treatment in the non-obese group (p<0.05). In obese individuals, FMD treatment led to an increase in salivary nitrite levels at 6 months (p<0.05); however, at 9 months, the nitrite levels returned to baseline levels. For both groups, the highest nitrite values were observed at 6 months. In addition, in both groups, FMD was associated with a decrease in biomarkers related to systemic inflammation and cardiovascular diseases, such as CRP (p<0.05) and alkaline phosphatase (p<0.05), and had no impact on the fasting blood glucose. This study demonstrates that obese patients with periodontitis present similar salivary nitrite levels when compared with non-obese individuals. FMD protocol resulted in increases in salivary nitrite levels and was associated with a positive impact on systemic biomarkers, regardless of obesity status.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402021000200027
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402021000200027
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-6440202103782
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
dc.source.none.fl_str_mv Brazilian Dental Journal v.32 n.2 2021
reponame:Brazilian Dental Journal
instname:Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron:FUNORP
instname_str Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron_str FUNORP
institution FUNORP
reponame_str Brazilian Dental Journal
collection Brazilian Dental Journal
repository.name.fl_str_mv Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)
repository.mail.fl_str_mv bdj@forp.usp.br||sergio@fosjc.unesp.br
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