Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Journal |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402003000200003 |
Resumo: | Enamel hypoplasia is an important clinical problem commonly seen in children born to diabetic women. We aimed to characterize the enamel hypoplasia in Wistar rats born to alloxan-induced diabetes mellitus rats. Groups consisted of pregnant rats supplemented (ISDR) or not (NISDR) with insulin and controls, in which sterile saline solution was administered instead of alloxan or insulin. The mandibular incisors of one-month-old rats born to these mothers were analyzed. Whitish defective enamel was found macroscopically in both experimental groups (ISDR = 37.5%, NISDR = 33.3%) but not in the control group. Mild to severe enamel hypoplasia was observed by scanning electron microscopy (ISDR = 93.8%; NISDR = 100%, control = 4.2%). The severity of hypoplasia correlated positively with the maternal level of blood glucose. In conclusion, the intensity of enamel hypoplasia in the teeth of the litter born to alloxan-induced diabetic rats was variable and was dependent on the glycemic level of the pregnant rat. |
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spelling |
Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitusenamel hypoplasiaalloxanmaternal diabetesdiabetes mellitusEnamel hypoplasia is an important clinical problem commonly seen in children born to diabetic women. We aimed to characterize the enamel hypoplasia in Wistar rats born to alloxan-induced diabetes mellitus rats. Groups consisted of pregnant rats supplemented (ISDR) or not (NISDR) with insulin and controls, in which sterile saline solution was administered instead of alloxan or insulin. The mandibular incisors of one-month-old rats born to these mothers were analyzed. Whitish defective enamel was found macroscopically in both experimental groups (ISDR = 37.5%, NISDR = 33.3%) but not in the control group. Mild to severe enamel hypoplasia was observed by scanning electron microscopy (ISDR = 93.8%; NISDR = 100%, control = 4.2%). The severity of hypoplasia correlated positively with the maternal level of blood glucose. In conclusion, the intensity of enamel hypoplasia in the teeth of the litter born to alloxan-induced diabetic rats was variable and was dependent on the glycemic level of the pregnant rat.Fundação Odontológica de Ribeirão Preto2003-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402003000200003Brazilian Dental Journal v.14 n.2 2003reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402003000200003info:eu-repo/semantics/openAccessSilva-Sousa,Yara Teresinha CorrêaPeres,Luiz CesarFoss,Milton Cesareng2003-10-02T00:00:00Zoai:scielo:S0103-64402003000200003Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2003-10-02T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus |
title |
Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus |
spellingShingle |
Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus Silva-Sousa,Yara Teresinha Corrêa enamel hypoplasia alloxan maternal diabetes diabetes mellitus |
title_short |
Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus |
title_full |
Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus |
title_fullStr |
Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus |
title_full_unstemmed |
Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus |
title_sort |
Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus |
author |
Silva-Sousa,Yara Teresinha Corrêa |
author_facet |
Silva-Sousa,Yara Teresinha Corrêa Peres,Luiz Cesar Foss,Milton Cesar |
author_role |
author |
author2 |
Peres,Luiz Cesar Foss,Milton Cesar |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Silva-Sousa,Yara Teresinha Corrêa Peres,Luiz Cesar Foss,Milton Cesar |
dc.subject.por.fl_str_mv |
enamel hypoplasia alloxan maternal diabetes diabetes mellitus |
topic |
enamel hypoplasia alloxan maternal diabetes diabetes mellitus |
description |
Enamel hypoplasia is an important clinical problem commonly seen in children born to diabetic women. We aimed to characterize the enamel hypoplasia in Wistar rats born to alloxan-induced diabetes mellitus rats. Groups consisted of pregnant rats supplemented (ISDR) or not (NISDR) with insulin and controls, in which sterile saline solution was administered instead of alloxan or insulin. The mandibular incisors of one-month-old rats born to these mothers were analyzed. Whitish defective enamel was found macroscopically in both experimental groups (ISDR = 37.5%, NISDR = 33.3%) but not in the control group. Mild to severe enamel hypoplasia was observed by scanning electron microscopy (ISDR = 93.8%; NISDR = 100%, control = 4.2%). The severity of hypoplasia correlated positively with the maternal level of blood glucose. In conclusion, the intensity of enamel hypoplasia in the teeth of the litter born to alloxan-induced diabetic rats was variable and was dependent on the glycemic level of the pregnant rat. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402003000200003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402003000200003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-64402003000200003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.14 n.2 2003 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204089683542016 |