Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus

Detalhes bibliográficos
Autor(a) principal: Silva-Sousa,Yara Teresinha Corrêa
Data de Publicação: 2003
Outros Autores: Peres,Luiz Cesar, Foss,Milton Cesar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Dental Journal
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402003000200003
Resumo: Enamel hypoplasia is an important clinical problem commonly seen in children born to diabetic women. We aimed to characterize the enamel hypoplasia in Wistar rats born to alloxan-induced diabetes mellitus rats. Groups consisted of pregnant rats supplemented (ISDR) or not (NISDR) with insulin and controls, in which sterile saline solution was administered instead of alloxan or insulin. The mandibular incisors of one-month-old rats born to these mothers were analyzed. Whitish defective enamel was found macroscopically in both experimental groups (ISDR = 37.5%, NISDR = 33.3%) but not in the control group. Mild to severe enamel hypoplasia was observed by scanning electron microscopy (ISDR = 93.8%; NISDR = 100%, control = 4.2%). The severity of hypoplasia correlated positively with the maternal level of blood glucose. In conclusion, the intensity of enamel hypoplasia in the teeth of the litter born to alloxan-induced diabetic rats was variable and was dependent on the glycemic level of the pregnant rat.
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spelling Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitusenamel hypoplasiaalloxanmaternal diabetesdiabetes mellitusEnamel hypoplasia is an important clinical problem commonly seen in children born to diabetic women. We aimed to characterize the enamel hypoplasia in Wistar rats born to alloxan-induced diabetes mellitus rats. Groups consisted of pregnant rats supplemented (ISDR) or not (NISDR) with insulin and controls, in which sterile saline solution was administered instead of alloxan or insulin. The mandibular incisors of one-month-old rats born to these mothers were analyzed. Whitish defective enamel was found macroscopically in both experimental groups (ISDR = 37.5%, NISDR = 33.3%) but not in the control group. Mild to severe enamel hypoplasia was observed by scanning electron microscopy (ISDR = 93.8%; NISDR = 100%, control = 4.2%). The severity of hypoplasia correlated positively with the maternal level of blood glucose. In conclusion, the intensity of enamel hypoplasia in the teeth of the litter born to alloxan-induced diabetic rats was variable and was dependent on the glycemic level of the pregnant rat.Fundação Odontológica de Ribeirão Preto2003-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402003000200003Brazilian Dental Journal v.14 n.2 2003reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402003000200003info:eu-repo/semantics/openAccessSilva-Sousa,Yara Teresinha CorrêaPeres,Luiz CesarFoss,Milton Cesareng2003-10-02T00:00:00Zoai:scielo:S0103-64402003000200003Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2003-10-02T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false
dc.title.none.fl_str_mv Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus
title Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus
spellingShingle Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus
Silva-Sousa,Yara Teresinha Corrêa
enamel hypoplasia
alloxan
maternal diabetes
diabetes mellitus
title_short Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus
title_full Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus
title_fullStr Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus
title_full_unstemmed Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus
title_sort Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus
author Silva-Sousa,Yara Teresinha Corrêa
author_facet Silva-Sousa,Yara Teresinha Corrêa
Peres,Luiz Cesar
Foss,Milton Cesar
author_role author
author2 Peres,Luiz Cesar
Foss,Milton Cesar
author2_role author
author
dc.contributor.author.fl_str_mv Silva-Sousa,Yara Teresinha Corrêa
Peres,Luiz Cesar
Foss,Milton Cesar
dc.subject.por.fl_str_mv enamel hypoplasia
alloxan
maternal diabetes
diabetes mellitus
topic enamel hypoplasia
alloxan
maternal diabetes
diabetes mellitus
description Enamel hypoplasia is an important clinical problem commonly seen in children born to diabetic women. We aimed to characterize the enamel hypoplasia in Wistar rats born to alloxan-induced diabetes mellitus rats. Groups consisted of pregnant rats supplemented (ISDR) or not (NISDR) with insulin and controls, in which sterile saline solution was administered instead of alloxan or insulin. The mandibular incisors of one-month-old rats born to these mothers were analyzed. Whitish defective enamel was found macroscopically in both experimental groups (ISDR = 37.5%, NISDR = 33.3%) but not in the control group. Mild to severe enamel hypoplasia was observed by scanning electron microscopy (ISDR = 93.8%; NISDR = 100%, control = 4.2%). The severity of hypoplasia correlated positively with the maternal level of blood glucose. In conclusion, the intensity of enamel hypoplasia in the teeth of the litter born to alloxan-induced diabetic rats was variable and was dependent on the glycemic level of the pregnant rat.
publishDate 2003
dc.date.none.fl_str_mv 2003-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402003000200003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402003000200003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-64402003000200003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
dc.source.none.fl_str_mv Brazilian Dental Journal v.14 n.2 2003
reponame:Brazilian Dental Journal
instname:Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron:FUNORP
instname_str Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron_str FUNORP
institution FUNORP
reponame_str Brazilian Dental Journal
collection Brazilian Dental Journal
repository.name.fl_str_mv Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)
repository.mail.fl_str_mv bdj@forp.usp.br||sergio@fosjc.unesp.br
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