Clinical and Histological Features of Multifocal Canalicular Adenomas of the Upper Lip

Detalhes bibliográficos
Autor(a) principal: Siqueira,Carla Silva
Data de Publicação: 2013
Outros Autores: Fernandes,Karin Sá, Vivas,Ana Paula Molina, Pinto Junior,Décio dos Santos, Sousa,Suzana Cantanhede Orsini Machado de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Dental Journal
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402013000500542
Resumo: Canalicular adenoma (CA) is an uncommon benign salivary gland tumor that mostly occurs in the upper lip. Despite its benign nature, some patients may present multiple nodules and also microscopic growth that can be multifocal with foci of tumor within the adjacent gland. Microscopically, CA can be mistaken for a polymorphous low-grade adenocarcinoma (PLGA) or basal cell adenoma (BCA), and immunohistochemistry can be helpful in differentiating them. Two cases of canalicular adenoma showing tumor foci within the adjacent gland are described. Both cases occurred in the upper lip of white females aged 72 and 79 years. In addition to the histological multifocal aspect, one of the patients presented bi-lateral nodules. Histological examination of both lesions revealed interconnecting and branching canal-like structures composed by uniform columnar and sometimes cuboidal cells, partially encapsulated. Immunohistochemical analysis showed intense expression of cytokeratins (CK) 7, a weak reaction to CK14 and a negative reaction to vimentin. Upon the diagnosis of CA the lesions were excised. In conclusion, it is important to properly diagnose CA and differentiate its multifocal aspect from a malignant behavior.
id FUNORP-1_21170b9a117a2a2a4f7ccae29b148b94
oai_identifier_str oai:scielo:S0103-64402013000500542
network_acronym_str FUNORP-1
network_name_str Brazilian Dental Journal
repository_id_str
spelling Clinical and Histological Features of Multifocal Canalicular Adenomas of the Upper Lipadenomahistopathologyimmunohistochemistryupper lipCanalicular adenoma (CA) is an uncommon benign salivary gland tumor that mostly occurs in the upper lip. Despite its benign nature, some patients may present multiple nodules and also microscopic growth that can be multifocal with foci of tumor within the adjacent gland. Microscopically, CA can be mistaken for a polymorphous low-grade adenocarcinoma (PLGA) or basal cell adenoma (BCA), and immunohistochemistry can be helpful in differentiating them. Two cases of canalicular adenoma showing tumor foci within the adjacent gland are described. Both cases occurred in the upper lip of white females aged 72 and 79 years. In addition to the histological multifocal aspect, one of the patients presented bi-lateral nodules. Histological examination of both lesions revealed interconnecting and branching canal-like structures composed by uniform columnar and sometimes cuboidal cells, partially encapsulated. Immunohistochemical analysis showed intense expression of cytokeratins (CK) 7, a weak reaction to CK14 and a negative reaction to vimentin. Upon the diagnosis of CA the lesions were excised. In conclusion, it is important to properly diagnose CA and differentiate its multifocal aspect from a malignant behavior.Fundação Odontológica de Ribeirão Preto2013-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402013000500542Brazilian Dental Journal v.24 n.5 2013reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/0103-6440201302264info:eu-repo/semantics/openAccessSiqueira,Carla SilvaFernandes,Karin SáVivas,Ana Paula MolinaPinto Junior,Décio dos SantosSousa,Suzana Cantanhede Orsini Machado deeng2015-10-27T00:00:00Zoai:scielo:S0103-64402013000500542Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2015-10-27T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false
dc.title.none.fl_str_mv Clinical and Histological Features of Multifocal Canalicular Adenomas of the Upper Lip
title Clinical and Histological Features of Multifocal Canalicular Adenomas of the Upper Lip
spellingShingle Clinical and Histological Features of Multifocal Canalicular Adenomas of the Upper Lip
Siqueira,Carla Silva
adenoma
histopathology
immunohistochemistry
upper lip
title_short Clinical and Histological Features of Multifocal Canalicular Adenomas of the Upper Lip
title_full Clinical and Histological Features of Multifocal Canalicular Adenomas of the Upper Lip
title_fullStr Clinical and Histological Features of Multifocal Canalicular Adenomas of the Upper Lip
title_full_unstemmed Clinical and Histological Features of Multifocal Canalicular Adenomas of the Upper Lip
title_sort Clinical and Histological Features of Multifocal Canalicular Adenomas of the Upper Lip
author Siqueira,Carla Silva
author_facet Siqueira,Carla Silva
Fernandes,Karin Sá
Vivas,Ana Paula Molina
Pinto Junior,Décio dos Santos
Sousa,Suzana Cantanhede Orsini Machado de
author_role author
author2 Fernandes,Karin Sá
Vivas,Ana Paula Molina
Pinto Junior,Décio dos Santos
Sousa,Suzana Cantanhede Orsini Machado de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Siqueira,Carla Silva
Fernandes,Karin Sá
Vivas,Ana Paula Molina
Pinto Junior,Décio dos Santos
Sousa,Suzana Cantanhede Orsini Machado de
dc.subject.por.fl_str_mv adenoma
histopathology
immunohistochemistry
upper lip
topic adenoma
histopathology
immunohistochemistry
upper lip
description Canalicular adenoma (CA) is an uncommon benign salivary gland tumor that mostly occurs in the upper lip. Despite its benign nature, some patients may present multiple nodules and also microscopic growth that can be multifocal with foci of tumor within the adjacent gland. Microscopically, CA can be mistaken for a polymorphous low-grade adenocarcinoma (PLGA) or basal cell adenoma (BCA), and immunohistochemistry can be helpful in differentiating them. Two cases of canalicular adenoma showing tumor foci within the adjacent gland are described. Both cases occurred in the upper lip of white females aged 72 and 79 years. In addition to the histological multifocal aspect, one of the patients presented bi-lateral nodules. Histological examination of both lesions revealed interconnecting and branching canal-like structures composed by uniform columnar and sometimes cuboidal cells, partially encapsulated. Immunohistochemical analysis showed intense expression of cytokeratins (CK) 7, a weak reaction to CK14 and a negative reaction to vimentin. Upon the diagnosis of CA the lesions were excised. In conclusion, it is important to properly diagnose CA and differentiate its multifocal aspect from a malignant behavior.
publishDate 2013
dc.date.none.fl_str_mv 2013-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402013000500542
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402013000500542
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-6440201302264
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
dc.source.none.fl_str_mv Brazilian Dental Journal v.24 n.5 2013
reponame:Brazilian Dental Journal
instname:Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron:FUNORP
instname_str Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron_str FUNORP
institution FUNORP
reponame_str Brazilian Dental Journal
collection Brazilian Dental Journal
repository.name.fl_str_mv Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)
repository.mail.fl_str_mv bdj@forp.usp.br||sergio@fosjc.unesp.br
_version_ 1754204092989702144