Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Journal |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402007000300003 |
Resumo: | Myoepithelial cells present a complex immunophenotype, with the expression of proteins varying according to the stage of normal or neoplastic differentiation of the cell. In order to evaluate the immunohistochemical markers expressed by these cells, a panel of antibodies composed of vimentin, calponin and HHF-35 was applied to 28 salivary gland tumors. The results demonstrated a higher percent sensitivity of vimentin and calponin compared to HHF-35. However, calponin and HHF-35 presented a focal labeling pattern in contrast with the diffuse distribution of vimentin. The cells predominantly stained by all tested antibodies included nonluminal cells in duct-like and tubular structures, such as those seen in pleomorphic adenomas and adenoid cystic carcinomas, as well as cells in the cords and nests of polymorphous low-grade adenocarcinomas and peripheral cells of sheets and nests of myoepitheliomas. In conclusion, the combination of calponin and vimentin is suggested for the identification of myoepithelial cells in salivary gland tumors. |
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Brazilian Dental Journal |
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Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumorsmyoepithelial cellsalivary gland tumorsvimentincalponinHHF-35Myoepithelial cells present a complex immunophenotype, with the expression of proteins varying according to the stage of normal or neoplastic differentiation of the cell. In order to evaluate the immunohistochemical markers expressed by these cells, a panel of antibodies composed of vimentin, calponin and HHF-35 was applied to 28 salivary gland tumors. The results demonstrated a higher percent sensitivity of vimentin and calponin compared to HHF-35. However, calponin and HHF-35 presented a focal labeling pattern in contrast with the diffuse distribution of vimentin. The cells predominantly stained by all tested antibodies included nonluminal cells in duct-like and tubular structures, such as those seen in pleomorphic adenomas and adenoid cystic carcinomas, as well as cells in the cords and nests of polymorphous low-grade adenocarcinomas and peripheral cells of sheets and nests of myoepitheliomas. In conclusion, the combination of calponin and vimentin is suggested for the identification of myoepithelial cells in salivary gland tumors.Fundação Odontológica de Ribeirão Preto2007-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402007000300003Brazilian Dental Journal v.18 n.3 2007reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402007000300003info:eu-repo/semantics/openAccessCavalcante,Roberta BarrosoLopes,Fernanda FerreiraFerreira,Andréa SoaresFreitas,Roseana de AlmeidaSouza,Lélia Batista deeng2007-12-21T00:00:00Zoai:scielo:S0103-64402007000300003Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2007-12-21T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors |
title |
Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors |
spellingShingle |
Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors Cavalcante,Roberta Barroso myoepithelial cell salivary gland tumors vimentin calponin HHF-35 |
title_short |
Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors |
title_full |
Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors |
title_fullStr |
Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors |
title_full_unstemmed |
Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors |
title_sort |
Immunohistochemical expression of vimentin, calponin and HHF-35 in salivary gland tumors |
author |
Cavalcante,Roberta Barroso |
author_facet |
Cavalcante,Roberta Barroso Lopes,Fernanda Ferreira Ferreira,Andréa Soares Freitas,Roseana de Almeida Souza,Lélia Batista de |
author_role |
author |
author2 |
Lopes,Fernanda Ferreira Ferreira,Andréa Soares Freitas,Roseana de Almeida Souza,Lélia Batista de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Cavalcante,Roberta Barroso Lopes,Fernanda Ferreira Ferreira,Andréa Soares Freitas,Roseana de Almeida Souza,Lélia Batista de |
dc.subject.por.fl_str_mv |
myoepithelial cell salivary gland tumors vimentin calponin HHF-35 |
topic |
myoepithelial cell salivary gland tumors vimentin calponin HHF-35 |
description |
Myoepithelial cells present a complex immunophenotype, with the expression of proteins varying according to the stage of normal or neoplastic differentiation of the cell. In order to evaluate the immunohistochemical markers expressed by these cells, a panel of antibodies composed of vimentin, calponin and HHF-35 was applied to 28 salivary gland tumors. The results demonstrated a higher percent sensitivity of vimentin and calponin compared to HHF-35. However, calponin and HHF-35 presented a focal labeling pattern in contrast with the diffuse distribution of vimentin. The cells predominantly stained by all tested antibodies included nonluminal cells in duct-like and tubular structures, such as those seen in pleomorphic adenomas and adenoid cystic carcinomas, as well as cells in the cords and nests of polymorphous low-grade adenocarcinomas and peripheral cells of sheets and nests of myoepitheliomas. In conclusion, the combination of calponin and vimentin is suggested for the identification of myoepithelial cells in salivary gland tumors. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402007000300003 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402007000300003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-64402007000300003 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.18 n.3 2007 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204090524499968 |