Clinical, microscopic and imaging findings associated to Mccune-Albright syndrome: report of two cases

Detalhes bibliográficos
Autor(a) principal: Xavier,Samuel Porfírio
Data de Publicação: 2008
Outros Autores: Ribeiro,Michel Campos, Sicchieri,Luciana Gonçalves, Brentegani,Luiz Guilherme, Lacerda,Suzie Aparecida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Dental Journal
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402008000200014
Resumo: McCune-Albright syndrome is characterized by the triad café-au-lait cutaneous spots, polyostotic fibrous dysplasia and endocrinopathies. This article presents two cases of McCune-Albright syndrome in a middle-aged woman and a young girl. Both patients presented café-au-lait spots on the face and other parts of the body and expansion of the mandible with radiopaque-radiolucent areas with ground-glass radiographic appearance, and were diagnosed as having fibrous dysplasia and endocrine disorders. The patient of Case 1 had fibrous dysplasia on the upper and lower limbs, thorax, face and cranium, early puberty, hyperglycemia, hyperthyroidism and high serum alkaline phosphatase levels. The patient of Case 2 presented lesions on the upper limbs and evident endocrine disorders. In both cases presented in this article, the initial exam was made because of the mandibular lesion. However, a diagnosis of fibrous dysplasia must lead to investigation of the involvement of other bones, characterizing polyostotic fibrous dysplasia, which is manifested in a number of diseases. An accurate differential diagnosis is mandatory to determine the best treatment approach for each case.
id FUNORP-1_c9a9d4a6efd3f4ddaa40f191bc8cc980
oai_identifier_str oai:scielo:S0103-64402008000200014
network_acronym_str FUNORP-1
network_name_str Brazilian Dental Journal
repository_id_str
spelling Clinical, microscopic and imaging findings associated to Mccune-Albright syndrome: report of two casesMcCune-Albright syndromepolyostotic fibrous dysplasiacafé-au-lait skin hyperpigmentationMcCune-Albright syndrome is characterized by the triad café-au-lait cutaneous spots, polyostotic fibrous dysplasia and endocrinopathies. This article presents two cases of McCune-Albright syndrome in a middle-aged woman and a young girl. Both patients presented café-au-lait spots on the face and other parts of the body and expansion of the mandible with radiopaque-radiolucent areas with ground-glass radiographic appearance, and were diagnosed as having fibrous dysplasia and endocrine disorders. The patient of Case 1 had fibrous dysplasia on the upper and lower limbs, thorax, face and cranium, early puberty, hyperglycemia, hyperthyroidism and high serum alkaline phosphatase levels. The patient of Case 2 presented lesions on the upper limbs and evident endocrine disorders. In both cases presented in this article, the initial exam was made because of the mandibular lesion. However, a diagnosis of fibrous dysplasia must lead to investigation of the involvement of other bones, characterizing polyostotic fibrous dysplasia, which is manifested in a number of diseases. An accurate differential diagnosis is mandatory to determine the best treatment approach for each case.Fundação Odontológica de Ribeirão Preto2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402008000200014Brazilian Dental Journal v.19 n.2 2008reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402008000200014info:eu-repo/semantics/openAccessXavier,Samuel PorfírioRibeiro,Michel CamposSicchieri,Luciana GonçalvesBrentegani,Luiz GuilhermeLacerda,Suzie Aparecidaeng2008-06-12T00:00:00Zoai:scielo:S0103-64402008000200014Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2008-06-12T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false
dc.title.none.fl_str_mv Clinical, microscopic and imaging findings associated to Mccune-Albright syndrome: report of two cases
title Clinical, microscopic and imaging findings associated to Mccune-Albright syndrome: report of two cases
spellingShingle Clinical, microscopic and imaging findings associated to Mccune-Albright syndrome: report of two cases
Xavier,Samuel Porfírio
McCune-Albright syndrome
polyostotic fibrous dysplasia
café-au-lait skin hyperpigmentation
title_short Clinical, microscopic and imaging findings associated to Mccune-Albright syndrome: report of two cases
title_full Clinical, microscopic and imaging findings associated to Mccune-Albright syndrome: report of two cases
title_fullStr Clinical, microscopic and imaging findings associated to Mccune-Albright syndrome: report of two cases
title_full_unstemmed Clinical, microscopic and imaging findings associated to Mccune-Albright syndrome: report of two cases
title_sort Clinical, microscopic and imaging findings associated to Mccune-Albright syndrome: report of two cases
author Xavier,Samuel Porfírio
author_facet Xavier,Samuel Porfírio
Ribeiro,Michel Campos
Sicchieri,Luciana Gonçalves
Brentegani,Luiz Guilherme
Lacerda,Suzie Aparecida
author_role author
author2 Ribeiro,Michel Campos
Sicchieri,Luciana Gonçalves
Brentegani,Luiz Guilherme
Lacerda,Suzie Aparecida
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Xavier,Samuel Porfírio
Ribeiro,Michel Campos
Sicchieri,Luciana Gonçalves
Brentegani,Luiz Guilherme
Lacerda,Suzie Aparecida
dc.subject.por.fl_str_mv McCune-Albright syndrome
polyostotic fibrous dysplasia
café-au-lait skin hyperpigmentation
topic McCune-Albright syndrome
polyostotic fibrous dysplasia
café-au-lait skin hyperpigmentation
description McCune-Albright syndrome is characterized by the triad café-au-lait cutaneous spots, polyostotic fibrous dysplasia and endocrinopathies. This article presents two cases of McCune-Albright syndrome in a middle-aged woman and a young girl. Both patients presented café-au-lait spots on the face and other parts of the body and expansion of the mandible with radiopaque-radiolucent areas with ground-glass radiographic appearance, and were diagnosed as having fibrous dysplasia and endocrine disorders. The patient of Case 1 had fibrous dysplasia on the upper and lower limbs, thorax, face and cranium, early puberty, hyperglycemia, hyperthyroidism and high serum alkaline phosphatase levels. The patient of Case 2 presented lesions on the upper limbs and evident endocrine disorders. In both cases presented in this article, the initial exam was made because of the mandibular lesion. However, a diagnosis of fibrous dysplasia must lead to investigation of the involvement of other bones, characterizing polyostotic fibrous dysplasia, which is manifested in a number of diseases. An accurate differential diagnosis is mandatory to determine the best treatment approach for each case.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402008000200014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402008000200014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-64402008000200014
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
dc.source.none.fl_str_mv Brazilian Dental Journal v.19 n.2 2008
reponame:Brazilian Dental Journal
instname:Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron:FUNORP
instname_str Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron_str FUNORP
institution FUNORP
reponame_str Brazilian Dental Journal
collection Brazilian Dental Journal
repository.name.fl_str_mv Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)
repository.mail.fl_str_mv bdj@forp.usp.br||sergio@fosjc.unesp.br
_version_ 1754204090869481472