Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Journal |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000500566 |
Resumo: | Abstract The aim of this study was to assess the imaging and histological features of experimental periapical lesions, including the adjacent alveolar bone, in rats under zoledronic acid treatment. The study used 40 male Wistar rats distributed into 8 groups of 5 animals each: G1: induction of periapical lesion (PL) and weekly intraperitoneal administration (WIPA) of saline solution (0.9% NaCl) for 4 weeks; G2: PL induction and WIPA of zoledronic acid (0.15 mg/kg/week) for 4 weeks; G3: PL induction and WIPA of saline solution for 8 weeks; G4: PL induction and WIPA of zoledronic acid for 8 weeks; G5:WIPA of saline solution for 4 weeks and subsequent PL induction; G6: WIPA of zoledronic acid for 4 weeks and subsequent PL induction; G7: WIPA of saline solution for 8 weeks and subsequent PL induction; G8: WIPA of zoledronic acid for 8 weeks and subsequent PL induction. The administration of zoledronic acid or saline solution continued after PL induction until the euthanasia. Thus, cone beam computed tomography and histological analysis were performed. Statistical analyzes were performed by ANOVA and Kruskal-Wallis test. Groups treated with zoledronic acid showed significantly smaller size of PL than the groups treated with 0.9% NaCl (p<0.05). PLs were formed by chronic inflammation ranging from mild to moderate, with no difference between groups. In all specimens, no mandibular necrosis was observed. In conclusion, the presence of PLs apparently does not represent an important risk factor for the development of bisphosphonate-related osteonecrosis of the jaws. |
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Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysisbisphosphonatesbisphosphonate-related osteonecrosis of the jawsEndodonticsperiapical lesionszoledronic acid.Abstract The aim of this study was to assess the imaging and histological features of experimental periapical lesions, including the adjacent alveolar bone, in rats under zoledronic acid treatment. The study used 40 male Wistar rats distributed into 8 groups of 5 animals each: G1: induction of periapical lesion (PL) and weekly intraperitoneal administration (WIPA) of saline solution (0.9% NaCl) for 4 weeks; G2: PL induction and WIPA of zoledronic acid (0.15 mg/kg/week) for 4 weeks; G3: PL induction and WIPA of saline solution for 8 weeks; G4: PL induction and WIPA of zoledronic acid for 8 weeks; G5:WIPA of saline solution for 4 weeks and subsequent PL induction; G6: WIPA of zoledronic acid for 4 weeks and subsequent PL induction; G7: WIPA of saline solution for 8 weeks and subsequent PL induction; G8: WIPA of zoledronic acid for 8 weeks and subsequent PL induction. The administration of zoledronic acid or saline solution continued after PL induction until the euthanasia. Thus, cone beam computed tomography and histological analysis were performed. Statistical analyzes were performed by ANOVA and Kruskal-Wallis test. Groups treated with zoledronic acid showed significantly smaller size of PL than the groups treated with 0.9% NaCl (p<0.05). PLs were formed by chronic inflammation ranging from mild to moderate, with no difference between groups. In all specimens, no mandibular necrosis was observed. In conclusion, the presence of PLs apparently does not represent an important risk factor for the development of bisphosphonate-related osteonecrosis of the jaws.Fundação Odontológica de Ribeirão Preto2017-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000500566Brazilian Dental Journal v.28 n.5 2017reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/0103-6440201601558info:eu-repo/semantics/openAccessFrança,Talita Ribeiro Tenório deRamos-Perez,Flávia Maria de MoraesPontual,Andrea dos AnjosCastro,Jurema Freire Lisboa deBonan,Paulo Rogério FerretiPerez,Danyel Elias da Cruzeng2017-11-17T00:00:00Zoai:scielo:S0103-64402017000500566Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2017-11-17T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis |
title |
Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis |
spellingShingle |
Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis França,Talita Ribeiro Tenório de bisphosphonates bisphosphonate-related osteonecrosis of the jaws Endodontics periapical lesions zoledronic acid. |
title_short |
Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis |
title_full |
Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis |
title_fullStr |
Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis |
title_full_unstemmed |
Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis |
title_sort |
Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis |
author |
França,Talita Ribeiro Tenório de |
author_facet |
França,Talita Ribeiro Tenório de Ramos-Perez,Flávia Maria de Moraes Pontual,Andrea dos Anjos Castro,Jurema Freire Lisboa de Bonan,Paulo Rogério Ferreti Perez,Danyel Elias da Cruz |
author_role |
author |
author2 |
Ramos-Perez,Flávia Maria de Moraes Pontual,Andrea dos Anjos Castro,Jurema Freire Lisboa de Bonan,Paulo Rogério Ferreti Perez,Danyel Elias da Cruz |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
França,Talita Ribeiro Tenório de Ramos-Perez,Flávia Maria de Moraes Pontual,Andrea dos Anjos Castro,Jurema Freire Lisboa de Bonan,Paulo Rogério Ferreti Perez,Danyel Elias da Cruz |
dc.subject.por.fl_str_mv |
bisphosphonates bisphosphonate-related osteonecrosis of the jaws Endodontics periapical lesions zoledronic acid. |
topic |
bisphosphonates bisphosphonate-related osteonecrosis of the jaws Endodontics periapical lesions zoledronic acid. |
description |
Abstract The aim of this study was to assess the imaging and histological features of experimental periapical lesions, including the adjacent alveolar bone, in rats under zoledronic acid treatment. The study used 40 male Wistar rats distributed into 8 groups of 5 animals each: G1: induction of periapical lesion (PL) and weekly intraperitoneal administration (WIPA) of saline solution (0.9% NaCl) for 4 weeks; G2: PL induction and WIPA of zoledronic acid (0.15 mg/kg/week) for 4 weeks; G3: PL induction and WIPA of saline solution for 8 weeks; G4: PL induction and WIPA of zoledronic acid for 8 weeks; G5:WIPA of saline solution for 4 weeks and subsequent PL induction; G6: WIPA of zoledronic acid for 4 weeks and subsequent PL induction; G7: WIPA of saline solution for 8 weeks and subsequent PL induction; G8: WIPA of zoledronic acid for 8 weeks and subsequent PL induction. The administration of zoledronic acid or saline solution continued after PL induction until the euthanasia. Thus, cone beam computed tomography and histological analysis were performed. Statistical analyzes were performed by ANOVA and Kruskal-Wallis test. Groups treated with zoledronic acid showed significantly smaller size of PL than the groups treated with 0.9% NaCl (p<0.05). PLs were formed by chronic inflammation ranging from mild to moderate, with no difference between groups. In all specimens, no mandibular necrosis was observed. In conclusion, the presence of PLs apparently does not represent an important risk factor for the development of bisphosphonate-related osteonecrosis of the jaws. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000500566 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000500566 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0103-6440201601558 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.28 n.5 2017 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204094851973120 |