Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis

Detalhes bibliográficos
Autor(a) principal: França,Talita Ribeiro Tenório de
Data de Publicação: 2017
Outros Autores: Ramos-Perez,Flávia Maria de Moraes, Pontual,Andrea dos Anjos, Castro,Jurema Freire Lisboa de, Bonan,Paulo Rogério Ferreti, Perez,Danyel Elias da Cruz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Dental Journal
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000500566
Resumo: Abstract The aim of this study was to assess the imaging and histological features of experimental periapical lesions, including the adjacent alveolar bone, in rats under zoledronic acid treatment. The study used 40 male Wistar rats distributed into 8 groups of 5 animals each: G1: induction of periapical lesion (PL) and weekly intraperitoneal administration (WIPA) of saline solution (0.9% NaCl) for 4 weeks; G2: PL induction and WIPA of zoledronic acid (0.15 mg/kg/week) for 4 weeks; G3: PL induction and WIPA of saline solution for 8 weeks; G4: PL induction and WIPA of zoledronic acid for 8 weeks; G5:WIPA of saline solution for 4 weeks and subsequent PL induction; G6: WIPA of zoledronic acid for 4 weeks and subsequent PL induction; G7: WIPA of saline solution for 8 weeks and subsequent PL induction; G8: WIPA of zoledronic acid for 8 weeks and subsequent PL induction. The administration of zoledronic acid or saline solution continued after PL induction until the euthanasia. Thus, cone beam computed tomography and histological analysis were performed. Statistical analyzes were performed by ANOVA and Kruskal-Wallis test. Groups treated with zoledronic acid showed significantly smaller size of PL than the groups treated with 0.9% NaCl (p<0.05). PLs were formed by chronic inflammation ranging from mild to moderate, with no difference between groups. In all specimens, no mandibular necrosis was observed. In conclusion, the presence of PLs apparently does not represent an important risk factor for the development of bisphosphonate-related osteonecrosis of the jaws.
id FUNORP-1_fc8b1d7466ebaf0ea5ee49f52c2de2e1
oai_identifier_str oai:scielo:S0103-64402017000500566
network_acronym_str FUNORP-1
network_name_str Brazilian Dental Journal
repository_id_str
spelling Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysisbisphosphonatesbisphosphonate-related osteonecrosis of the jawsEndodonticsperiapical lesionszoledronic acid.Abstract The aim of this study was to assess the imaging and histological features of experimental periapical lesions, including the adjacent alveolar bone, in rats under zoledronic acid treatment. The study used 40 male Wistar rats distributed into 8 groups of 5 animals each: G1: induction of periapical lesion (PL) and weekly intraperitoneal administration (WIPA) of saline solution (0.9% NaCl) for 4 weeks; G2: PL induction and WIPA of zoledronic acid (0.15 mg/kg/week) for 4 weeks; G3: PL induction and WIPA of saline solution for 8 weeks; G4: PL induction and WIPA of zoledronic acid for 8 weeks; G5:WIPA of saline solution for 4 weeks and subsequent PL induction; G6: WIPA of zoledronic acid for 4 weeks and subsequent PL induction; G7: WIPA of saline solution for 8 weeks and subsequent PL induction; G8: WIPA of zoledronic acid for 8 weeks and subsequent PL induction. The administration of zoledronic acid or saline solution continued after PL induction until the euthanasia. Thus, cone beam computed tomography and histological analysis were performed. Statistical analyzes were performed by ANOVA and Kruskal-Wallis test. Groups treated with zoledronic acid showed significantly smaller size of PL than the groups treated with 0.9% NaCl (p<0.05). PLs were formed by chronic inflammation ranging from mild to moderate, with no difference between groups. In all specimens, no mandibular necrosis was observed. In conclusion, the presence of PLs apparently does not represent an important risk factor for the development of bisphosphonate-related osteonecrosis of the jaws.Fundação Odontológica de Ribeirão Preto2017-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000500566Brazilian Dental Journal v.28 n.5 2017reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/0103-6440201601558info:eu-repo/semantics/openAccessFrança,Talita Ribeiro Tenório deRamos-Perez,Flávia Maria de MoraesPontual,Andrea dos AnjosCastro,Jurema Freire Lisboa deBonan,Paulo Rogério FerretiPerez,Danyel Elias da Cruzeng2017-11-17T00:00:00Zoai:scielo:S0103-64402017000500566Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2017-11-17T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false
dc.title.none.fl_str_mv Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis
title Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis
spellingShingle Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis
França,Talita Ribeiro Tenório de
bisphosphonates
bisphosphonate-related osteonecrosis of the jaws
Endodontics
periapical lesions
zoledronic acid.
title_short Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis
title_full Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis
title_fullStr Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis
title_full_unstemmed Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis
title_sort Effects of Zoledronic Acid in Experimental Periapical Lesions in Rats: An Imaging and Histological Analysis
author França,Talita Ribeiro Tenório de
author_facet França,Talita Ribeiro Tenório de
Ramos-Perez,Flávia Maria de Moraes
Pontual,Andrea dos Anjos
Castro,Jurema Freire Lisboa de
Bonan,Paulo Rogério Ferreti
Perez,Danyel Elias da Cruz
author_role author
author2 Ramos-Perez,Flávia Maria de Moraes
Pontual,Andrea dos Anjos
Castro,Jurema Freire Lisboa de
Bonan,Paulo Rogério Ferreti
Perez,Danyel Elias da Cruz
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv França,Talita Ribeiro Tenório de
Ramos-Perez,Flávia Maria de Moraes
Pontual,Andrea dos Anjos
Castro,Jurema Freire Lisboa de
Bonan,Paulo Rogério Ferreti
Perez,Danyel Elias da Cruz
dc.subject.por.fl_str_mv bisphosphonates
bisphosphonate-related osteonecrosis of the jaws
Endodontics
periapical lesions
zoledronic acid.
topic bisphosphonates
bisphosphonate-related osteonecrosis of the jaws
Endodontics
periapical lesions
zoledronic acid.
description Abstract The aim of this study was to assess the imaging and histological features of experimental periapical lesions, including the adjacent alveolar bone, in rats under zoledronic acid treatment. The study used 40 male Wistar rats distributed into 8 groups of 5 animals each: G1: induction of periapical lesion (PL) and weekly intraperitoneal administration (WIPA) of saline solution (0.9% NaCl) for 4 weeks; G2: PL induction and WIPA of zoledronic acid (0.15 mg/kg/week) for 4 weeks; G3: PL induction and WIPA of saline solution for 8 weeks; G4: PL induction and WIPA of zoledronic acid for 8 weeks; G5:WIPA of saline solution for 4 weeks and subsequent PL induction; G6: WIPA of zoledronic acid for 4 weeks and subsequent PL induction; G7: WIPA of saline solution for 8 weeks and subsequent PL induction; G8: WIPA of zoledronic acid for 8 weeks and subsequent PL induction. The administration of zoledronic acid or saline solution continued after PL induction until the euthanasia. Thus, cone beam computed tomography and histological analysis were performed. Statistical analyzes were performed by ANOVA and Kruskal-Wallis test. Groups treated with zoledronic acid showed significantly smaller size of PL than the groups treated with 0.9% NaCl (p<0.05). PLs were formed by chronic inflammation ranging from mild to moderate, with no difference between groups. In all specimens, no mandibular necrosis was observed. In conclusion, the presence of PLs apparently does not represent an important risk factor for the development of bisphosphonate-related osteonecrosis of the jaws.
publishDate 2017
dc.date.none.fl_str_mv 2017-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000500566
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402017000500566
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-6440201601558
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
dc.source.none.fl_str_mv Brazilian Dental Journal v.28 n.5 2017
reponame:Brazilian Dental Journal
instname:Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron:FUNORP
instname_str Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron_str FUNORP
institution FUNORP
reponame_str Brazilian Dental Journal
collection Brazilian Dental Journal
repository.name.fl_str_mv Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)
repository.mail.fl_str_mv bdj@forp.usp.br||sergio@fosjc.unesp.br
_version_ 1754204094851973120