USE OF THE ANTIOXIDANT Ilex Paraguariensis IN THE INJURY OF LIVER ISCHEMIA AND REPERFUSION: A HISTOMORPHOLOGIC STUDY

Detalhes bibliográficos
Autor(a) principal: Mazorco, Ana Luísa Mattos
Data de Publicação: 2011
Outros Autores: Silva, Rodrigo Rodrigues, Espíndola, Wendel, Mucillo-Baish, Ana Luiza, Medeiros, Susi Heliene Lauz
Tipo de documento: Artigo
Idioma: por
Título da fonte: Vittalle (Online)
Texto Completo: https://periodicos.furg.br/vittalle/article/view/1854
Resumo: Due to the blood flow interruption, liver ischemia is used in surgical procedures of hepatic resection, transplantation, and secondary hemorrhage from trauma. The objective of this study was to protect the liver parenchyma during ischemia and reperfusion under the effect of Ilex paragiariensis. Eighteen three-month-old Wistar mice were divided into three groups: control group with administration of serum glucose 5%, group N-acetylcysteine 10%, and group Ilex paraguariensis 900 mg/mL. Every group had the liver triad clamped and thirty minutes of ischemia followed by 15 minutes of reperfusion. The animals were taken to euthanasia under anesthesia by blood removal. Their livers were examined by optical microscopy, and they were found as expanded and with the center-lobular vein and sinusoids congested. In conclusion, Ilex paraguariensis was verified as capable of maintaining the morphological structure of the liver parenchyma compared to the effect of N-acetylcysteine in the injury of liver ischemia and reperfusion in mice.
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spelling USE OF THE ANTIOXIDANT Ilex Paraguariensis IN THE INJURY OF LIVER ISCHEMIA AND REPERFUSION: A HISTOMORPHOLOGIC STUDYESTUDO HISTOMORFOLÓGICO DO USO DO ANTIOXIDANTE Ilex Paraguariensis NA LESÃO DE ISQUEMIA E REPERFUSÃO HEPÁTICAFígadoIsquemiaReperfusãoDue to the blood flow interruption, liver ischemia is used in surgical procedures of hepatic resection, transplantation, and secondary hemorrhage from trauma. The objective of this study was to protect the liver parenchyma during ischemia and reperfusion under the effect of Ilex paragiariensis. Eighteen three-month-old Wistar mice were divided into three groups: control group with administration of serum glucose 5%, group N-acetylcysteine 10%, and group Ilex paraguariensis 900 mg/mL. Every group had the liver triad clamped and thirty minutes of ischemia followed by 15 minutes of reperfusion. The animals were taken to euthanasia under anesthesia by blood removal. Their livers were examined by optical microscopy, and they were found as expanded and with the center-lobular vein and sinusoids congested. In conclusion, Ilex paraguariensis was verified as capable of maintaining the morphological structure of the liver parenchyma compared to the effect of N-acetylcysteine in the injury of liver ischemia and reperfusion in mice.A isquemia hepática, devido à interrupção do fluxo sanguíneo, é utilizada na ressecção hepática, transplante e em sangramentos decorrentes de traumas. O objetivo deste trabalho foi estudar a proteção do parênquima hepático durante período de isquemia e reperfusão sob efeito de Ilex paraguariensis. Dezoito ratos Wistar com três meses foram distribuídos em três grupos: grupo controle com administração de soro glicosado 5%, grupo N-acetilcisteína 10%, grupo Ilex paraguariensis (900 µg/mL), todos com clampeamento da tríade hepática e 30 minutos de isquemia seguidos por 15 minutos de reperfusão. Os animais foram levados à eutanásia, sob anestesia por exosanguinação. O fígado foi analisado por microscopia óptica, observando-se dilatação, congestão da veia centrolobular e dos sinusóides. Concluiu-se que Ilex paraguariensis é capaz de manter a estrutura morfológica do parênquima hepático quando comparada à ação da N-acetilcisteína na lesão de isquemia e reperfusão hepática em ratos.Universidade Federal do Rio Grande2011-03-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.furg.br/vittalle/article/view/1854VITTALLE - Revista de Ciências da Saúde; v. 21 n. 1 (2009); 43-502177-78531413-3563reponame:Vittalle (Online)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGporhttps://periodicos.furg.br/vittalle/article/view/1854/984Copyright (c) 2014 VITTALLE - Revista de Ciências da Saúdeinfo:eu-repo/semantics/openAccessMazorco, Ana Luísa MattosSilva, Rodrigo RodriguesEspíndola, WendelMucillo-Baish, Ana LuizaMedeiros, Susi Heliene Lauz2018-11-09T13:09:14Zoai:periodicos.furg.br:article/1854Revistahttps://periodicos.furg.br/vittallePUBhttps://periodicos.furg.br/vittalle/oaivittalle@furg.br2177-78531413-3563opendoar:2018-11-09T13:09:14Vittalle (Online) - Universidade Federal do Rio Grande (FURG)false
dc.title.none.fl_str_mv USE OF THE ANTIOXIDANT Ilex Paraguariensis IN THE INJURY OF LIVER ISCHEMIA AND REPERFUSION: A HISTOMORPHOLOGIC STUDY
ESTUDO HISTOMORFOLÓGICO DO USO DO ANTIOXIDANTE Ilex Paraguariensis NA LESÃO DE ISQUEMIA E REPERFUSÃO HEPÁTICA
title USE OF THE ANTIOXIDANT Ilex Paraguariensis IN THE INJURY OF LIVER ISCHEMIA AND REPERFUSION: A HISTOMORPHOLOGIC STUDY
spellingShingle USE OF THE ANTIOXIDANT Ilex Paraguariensis IN THE INJURY OF LIVER ISCHEMIA AND REPERFUSION: A HISTOMORPHOLOGIC STUDY
Mazorco, Ana Luísa Mattos
Fígado
Isquemia
Reperfusão
title_short USE OF THE ANTIOXIDANT Ilex Paraguariensis IN THE INJURY OF LIVER ISCHEMIA AND REPERFUSION: A HISTOMORPHOLOGIC STUDY
title_full USE OF THE ANTIOXIDANT Ilex Paraguariensis IN THE INJURY OF LIVER ISCHEMIA AND REPERFUSION: A HISTOMORPHOLOGIC STUDY
title_fullStr USE OF THE ANTIOXIDANT Ilex Paraguariensis IN THE INJURY OF LIVER ISCHEMIA AND REPERFUSION: A HISTOMORPHOLOGIC STUDY
title_full_unstemmed USE OF THE ANTIOXIDANT Ilex Paraguariensis IN THE INJURY OF LIVER ISCHEMIA AND REPERFUSION: A HISTOMORPHOLOGIC STUDY
title_sort USE OF THE ANTIOXIDANT Ilex Paraguariensis IN THE INJURY OF LIVER ISCHEMIA AND REPERFUSION: A HISTOMORPHOLOGIC STUDY
author Mazorco, Ana Luísa Mattos
author_facet Mazorco, Ana Luísa Mattos
Silva, Rodrigo Rodrigues
Espíndola, Wendel
Mucillo-Baish, Ana Luiza
Medeiros, Susi Heliene Lauz
author_role author
author2 Silva, Rodrigo Rodrigues
Espíndola, Wendel
Mucillo-Baish, Ana Luiza
Medeiros, Susi Heliene Lauz
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mazorco, Ana Luísa Mattos
Silva, Rodrigo Rodrigues
Espíndola, Wendel
Mucillo-Baish, Ana Luiza
Medeiros, Susi Heliene Lauz
dc.subject.por.fl_str_mv Fígado
Isquemia
Reperfusão
topic Fígado
Isquemia
Reperfusão
description Due to the blood flow interruption, liver ischemia is used in surgical procedures of hepatic resection, transplantation, and secondary hemorrhage from trauma. The objective of this study was to protect the liver parenchyma during ischemia and reperfusion under the effect of Ilex paragiariensis. Eighteen three-month-old Wistar mice were divided into three groups: control group with administration of serum glucose 5%, group N-acetylcysteine 10%, and group Ilex paraguariensis 900 mg/mL. Every group had the liver triad clamped and thirty minutes of ischemia followed by 15 minutes of reperfusion. The animals were taken to euthanasia under anesthesia by blood removal. Their livers were examined by optical microscopy, and they were found as expanded and with the center-lobular vein and sinusoids congested. In conclusion, Ilex paraguariensis was verified as capable of maintaining the morphological structure of the liver parenchyma compared to the effect of N-acetylcysteine in the injury of liver ischemia and reperfusion in mice.
publishDate 2011
dc.date.none.fl_str_mv 2011-03-10
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.furg.br/vittalle/article/view/1854
url https://periodicos.furg.br/vittalle/article/view/1854
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.furg.br/vittalle/article/view/1854/984
dc.rights.driver.fl_str_mv Copyright (c) 2014 VITTALLE - Revista de Ciências da Saúde
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2014 VITTALLE - Revista de Ciências da Saúde
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande
publisher.none.fl_str_mv Universidade Federal do Rio Grande
dc.source.none.fl_str_mv VITTALLE - Revista de Ciências da Saúde; v. 21 n. 1 (2009); 43-50
2177-7853
1413-3563
reponame:Vittalle (Online)
instname:Universidade Federal do Rio Grande (FURG)
instacron:FURG
instname_str Universidade Federal do Rio Grande (FURG)
instacron_str FURG
institution FURG
reponame_str Vittalle (Online)
collection Vittalle (Online)
repository.name.fl_str_mv Vittalle (Online) - Universidade Federal do Rio Grande (FURG)
repository.mail.fl_str_mv vittalle@furg.br
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