ILEX PARAGUARIENSIS EFFECT IN RATS AMINOTRASNFERASES SUBMITTED TO HEPATIC ISCHEMIA AND REPERFUSION

Detalhes bibliográficos
Autor(a) principal: Mazorco, Ana Luísa Mattos
Data de Publicação: 2013
Outros Autores: Facin, Emilio, de Souza, Michele Moraes, Baisch, Ana Luiza Muccillo, Lauz, Susi
Tipo de documento: Artigo
Idioma: por
Título da fonte: Vittalle (Online)
Texto Completo: https://periodicos.furg.br/vittalle/article/view/1669
Resumo: Objective: To study the effect of Ilex paraguariensis extract of rats aminotransferases subjected to ischemia and reperfusion (IR) liver. Methods: 24 male Wistar rats divided into: control group (CG), Ilex Group, 90 days (IG-90), Ilex Group 60 days (IG-60), Ilex Group 30 days (GI-30). Was administered approximately 900 µg Ilex paraguariensis orally daily for 30 days in GI-30 for 60 days in GI-60 and 90 days in GI-90 and the control group (CG) was administered water ad libitum for 90 days. Hepatic ischemia was proceeded for 30 minutes in all groups and followed by reperfusion for 45 minutes of reperfusion. The animals were anesthetized intramuscularly with xylazine (25 mg kg-1) / ketamine (50 mg kg-1). After the reperfusion was collected blood and measured levels of aminotransferases, followed by euthanasia. Results: The levels of AST and ALT were significantly similar to the control group. Conclusion: This study found no changes in the levels of AST and ALT, in comparison between the experimental groups (90, 60 and 30 days) with the control group. Key words: Ischemia-reperfusion, Liver, Ilex paraguariensis
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spelling ILEX PARAGUARIENSIS EFFECT IN RATS AMINOTRASNFERASES SUBMITTED TO HEPATIC ISCHEMIA AND REPERFUSIONEFECTO DE ILEX PARAGUARIENSIS EN RATAS AMINOTRANSFERASES FASE HÍGADO ISQUEMIA Y REPERFUSIÓNEFEITO DA ILEX PARAGUARIENSIS NAS AMINOTRANSFERASES DE RATOS SUBMETIDOS À ISQUEMIA E REPERFUSÃO HEPÁTICAisquemia e reperfusãofígadoIlex paraguariensisObjective: To study the effect of Ilex paraguariensis extract of rats aminotransferases subjected to ischemia and reperfusion (IR) liver. Methods: 24 male Wistar rats divided into: control group (CG), Ilex Group, 90 days (IG-90), Ilex Group 60 days (IG-60), Ilex Group 30 days (GI-30). Was administered approximately 900 µg Ilex paraguariensis orally daily for 30 days in GI-30 for 60 days in GI-60 and 90 days in GI-90 and the control group (CG) was administered water ad libitum for 90 days. Hepatic ischemia was proceeded for 30 minutes in all groups and followed by reperfusion for 45 minutes of reperfusion. The animals were anesthetized intramuscularly with xylazine (25 mg kg-1) / ketamine (50 mg kg-1). After the reperfusion was collected blood and measured levels of aminotransferases, followed by euthanasia. Results: The levels of AST and ALT were significantly similar to the control group. Conclusion: This study found no changes in the levels of AST and ALT, in comparison between the experimental groups (90, 60 and 30 days) with the control group. Key words: Ischemia-reperfusion, Liver, Ilex paraguariensisObjetivo: Estudiar El efecto Del extracto de ilex paraguariensis de aminotransferasas em ratas sometidas a isquemia y reperfusión (I/R) Del hígado. Métodos: 24 ratas Wistar macho divididas en: grupo control (GC), 90 días Ilex Group (IG-90), 60 días Ilex Group (IG-60), Ilex Grupo 30 (IG-30). Se administró aproximadamente 900 μmg Ilex paraguariensis por vía oral diariamente durante 30 días en el GI-30 durante 60 días en el GI-60 y 90 días en el GI-90 y el grupo control (GC) se administró agua ad libitum durante 90 días. isquemia hepática fue de 30 minutos en todos los grupos, seguido de reperfusión durante 45 minutos de reperfusión. Los animales fueron anestesiados por vía intramuscular con xilazina (25 mg kg-1) / ketamina (50 mg kg-1). Después de la finalización del período de reperfusión se recogió de la sangre venosa y los niveles de medición de las aminotransferasas, seguida de la eutanasia por exosanguination. Resultados: Los niveles de AST y ALT fue significativamente similar a la del grupo control. Conclusión: Este estudio no encontró cambios en los niveles de AST y ALT, en la comparación entre los grupos experimentales (días 90, 60 y 30) con el grupo control. Palabras clave: isquemia-reperfusión, hígado, Ilex paraguariensisObjetivo: Estudar o efeito do extrato da Ilex paraguariensis nas aminotransferases de ratos submetidos à isquemia e reperfusão (IR) hepática. Métodos: Foram utilizados 24 Ratos Wistar machos distribuídos em: Grupo controle (GC), Grupo Ilex 90 dias (GI-90), Grupo Ilex 60 dias (GI-60), Grupo Ilex 30 (GI-30). Foi administrado aproximadamente 900 µmg de Ilex paraguariensis via oral diariamente por 30 dias no grupo GI-30, por 60 dias no grupo GI-60 e por durante 90 dias no grupo GI-90 e no grupo controle (GC), administrou-se água ad libitum por 90 dias. A isquemia hepática foi de 30 minutos em todos os grupos e seguida de reperfusão de 45 minutos reperfusão. Os animais foram anestesiados via intramuscular com xilazina (25 mg/Kg-1 ) /ketamina (50 mg/Kg-1 ). Após completado o período de reperfusão foi realizada coleta de sangue venoso e dosagem das aminotransferases, seguido de eutanásia por exosanguinação. Resultados: Os níveis de AST e ALT foram significativamente semelhantes ao do grupo controle. Conclusão: Nesse estudo não se encontraram alterações dos níveis de AST e ALT, quando se comparam os grupos experimento (90, 60 e 30 dias) com o grupo controle. Descritores: Isquemia-reperfusão, Fígado, Ilex paraguariensisUniversidade Federal do Rio Grande2013-11-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionmétodoapplication/pdfhttps://periodicos.furg.br/vittalle/article/view/1669VITTALLE - Revista de Ciências da Saúde; v. 23 n. 1 (2011); 29-352177-78531413-3563reponame:Vittalle (Online)instname:Universidade Federal do Rio Grande (FURG)instacron:FURGporhttps://periodicos.furg.br/vittalle/article/view/1669/2416Copyright (c) 2014 VITTALLE - Revista de Ciências da Saúdeinfo:eu-repo/semantics/openAccessMazorco, Ana Luísa MattosFacin, Emiliode Souza, Michele MoraesBaisch, Ana Luiza MuccilloLauz, Susi2018-11-09T12:57:04Zoai:periodicos.furg.br:article/1669Revistahttps://periodicos.furg.br/vittallePUBhttps://periodicos.furg.br/vittalle/oaivittalle@furg.br2177-78531413-3563opendoar:2018-11-09T12:57:04Vittalle (Online) - Universidade Federal do Rio Grande (FURG)false
dc.title.none.fl_str_mv ILEX PARAGUARIENSIS EFFECT IN RATS AMINOTRASNFERASES SUBMITTED TO HEPATIC ISCHEMIA AND REPERFUSION
EFECTO DE ILEX PARAGUARIENSIS EN RATAS AMINOTRANSFERASES FASE HÍGADO ISQUEMIA Y REPERFUSIÓN
EFEITO DA ILEX PARAGUARIENSIS NAS AMINOTRANSFERASES DE RATOS SUBMETIDOS À ISQUEMIA E REPERFUSÃO HEPÁTICA
title ILEX PARAGUARIENSIS EFFECT IN RATS AMINOTRASNFERASES SUBMITTED TO HEPATIC ISCHEMIA AND REPERFUSION
spellingShingle ILEX PARAGUARIENSIS EFFECT IN RATS AMINOTRASNFERASES SUBMITTED TO HEPATIC ISCHEMIA AND REPERFUSION
Mazorco, Ana Luísa Mattos
isquemia e reperfusão
fígado
Ilex paraguariensis
title_short ILEX PARAGUARIENSIS EFFECT IN RATS AMINOTRASNFERASES SUBMITTED TO HEPATIC ISCHEMIA AND REPERFUSION
title_full ILEX PARAGUARIENSIS EFFECT IN RATS AMINOTRASNFERASES SUBMITTED TO HEPATIC ISCHEMIA AND REPERFUSION
title_fullStr ILEX PARAGUARIENSIS EFFECT IN RATS AMINOTRASNFERASES SUBMITTED TO HEPATIC ISCHEMIA AND REPERFUSION
title_full_unstemmed ILEX PARAGUARIENSIS EFFECT IN RATS AMINOTRASNFERASES SUBMITTED TO HEPATIC ISCHEMIA AND REPERFUSION
title_sort ILEX PARAGUARIENSIS EFFECT IN RATS AMINOTRASNFERASES SUBMITTED TO HEPATIC ISCHEMIA AND REPERFUSION
author Mazorco, Ana Luísa Mattos
author_facet Mazorco, Ana Luísa Mattos
Facin, Emilio
de Souza, Michele Moraes
Baisch, Ana Luiza Muccillo
Lauz, Susi
author_role author
author2 Facin, Emilio
de Souza, Michele Moraes
Baisch, Ana Luiza Muccillo
Lauz, Susi
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mazorco, Ana Luísa Mattos
Facin, Emilio
de Souza, Michele Moraes
Baisch, Ana Luiza Muccillo
Lauz, Susi
dc.subject.por.fl_str_mv isquemia e reperfusão
fígado
Ilex paraguariensis
topic isquemia e reperfusão
fígado
Ilex paraguariensis
description Objective: To study the effect of Ilex paraguariensis extract of rats aminotransferases subjected to ischemia and reperfusion (IR) liver. Methods: 24 male Wistar rats divided into: control group (CG), Ilex Group, 90 days (IG-90), Ilex Group 60 days (IG-60), Ilex Group 30 days (GI-30). Was administered approximately 900 µg Ilex paraguariensis orally daily for 30 days in GI-30 for 60 days in GI-60 and 90 days in GI-90 and the control group (CG) was administered water ad libitum for 90 days. Hepatic ischemia was proceeded for 30 minutes in all groups and followed by reperfusion for 45 minutes of reperfusion. The animals were anesthetized intramuscularly with xylazine (25 mg kg-1) / ketamine (50 mg kg-1). After the reperfusion was collected blood and measured levels of aminotransferases, followed by euthanasia. Results: The levels of AST and ALT were significantly similar to the control group. Conclusion: This study found no changes in the levels of AST and ALT, in comparison between the experimental groups (90, 60 and 30 days) with the control group. Key words: Ischemia-reperfusion, Liver, Ilex paraguariensis
publishDate 2013
dc.date.none.fl_str_mv 2013-11-22
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
método
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.furg.br/vittalle/article/view/1669
url https://periodicos.furg.br/vittalle/article/view/1669
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.furg.br/vittalle/article/view/1669/2416
dc.rights.driver.fl_str_mv Copyright (c) 2014 VITTALLE - Revista de Ciências da Saúde
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2014 VITTALLE - Revista de Ciências da Saúde
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande
publisher.none.fl_str_mv Universidade Federal do Rio Grande
dc.source.none.fl_str_mv VITTALLE - Revista de Ciências da Saúde; v. 23 n. 1 (2011); 29-35
2177-7853
1413-3563
reponame:Vittalle (Online)
instname:Universidade Federal do Rio Grande (FURG)
instacron:FURG
instname_str Universidade Federal do Rio Grande (FURG)
instacron_str FURG
institution FURG
reponame_str Vittalle (Online)
collection Vittalle (Online)
repository.name.fl_str_mv Vittalle (Online) - Universidade Federal do Rio Grande (FURG)
repository.mail.fl_str_mv vittalle@furg.br
_version_ 1797041718601711616

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